| MeSH term | MeSH ID | Detail |
|---|---|---|
| Irritable Bowel Syndrome | D043183 | 8 associated lipids |
| Overweight | D050177 | 11 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang MH et al. | Comparative GC/MS analysis of essential oils extracted by 3 methods from the bud of Citrus aurantium L. var. amara Engl. | 2011 Nov-Dec | J. Food Sci. | pmid:22416680 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| Azrad M et al. | Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. | 2012 | PLoS ONE | pmid:23285256 |
| Wang X et al. | Transcriptome analysis of Sacha Inchi (Plukenetia volubilis L.) seeds at two developmental stages. | 2012 | BMC Genomics | pmid:23256450 |
| Sugasini D and Lokesh BR | Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. | 2012 | Lipids | pmid:23104428 |
| Pany S et al. | PKC activation by resveratrol derivatives with unsaturated aliphatic chain. | 2012 | PLoS ONE | pmid:23285216 |
| Astiz M et al. | Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. | 2012 | Lipids | pmid:22476691 |
| Macášek J et al. | Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. | 2012 | Nutr Cancer | pmid:23061902 |
| Vanden Heuvel JP et al. | Mechanistic examination of walnuts in prevention of breast cancer. | 2012 | Nutr Cancer | pmid:23061909 |
| Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
| Kim DH et al. | Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. | 2012 | Yonsei Med. J. | pmid:23074118 |
| Pan A et al. | α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. | 2012 | Am. J. Clin. Nutr. | pmid:23076616 |
| Barrett E et al. | Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome. | 2012 | PLoS ONE | pmid:23185248 |
| Fang XL et al. | Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. | 2012 | Mol. Biol. Rep. | pmid:23053988 |
| He ML et al. | Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. | 2012 | Lipids | pmid:23054550 |
| Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
| Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
| Gutla PV et al. | Modulation of plant TPC channels by polyunsaturated fatty acids. | 2012 | J. Exp. Bot. | pmid:23105130 |
| Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Garcia CV et al. | Characterisation of bound volatile compounds of a low flavour kiwifruit species: Actinidia eriantha. | 2012 | Food Chem | pmid:23107675 |
| Beck JJ et al. | Generation of the volatile spiroketals conophthorin and chalcogran by fungal spores on polyunsaturated fatty acids common to almonds and pistachios. | 2012 | J. Agric. Food Chem. | pmid:23153034 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
| Han SN et al. | Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. | 2012 | J. Nutr. | pmid:23096013 |
| Saha SS et al. | Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. | 2012 | Biochim. Biophys. Acta | pmid:22967758 |
| Vecchio AJ et al. | Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. | 2012 | J. Biol. Chem. | pmid:22637474 |
| Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
| Ngaki MN et al. | Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. | 2012 | Nature | pmid:22622584 |
| Yang Q et al. | Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. | 2012 | Theor. Appl. Genet. | pmid:22534790 |
| von Berlepsch S et al. | The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. | 2012 | Plant Physiol. | pmid:22535424 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
| Demchenko K et al. | Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. | 2012 | Plant Biol (Stuttg) | pmid:21973171 |
| Jackson MD et al. | Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. | 2012 | Cancer Causes Control | pmid:21984307 |
| de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
| Zhang J et al. | Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. | 2012 | J. Nutr. Biochem. | pmid:21658928 |
| He ML et al. | Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. | 2012 | J. Anim. Sci. | pmid:22274861 |
| Poudyal H et al. | Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. | 2012 | J. Nutr. Biochem. | pmid:21429727 |
| Sun T et al. | Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. | 2012 | J. Sci. Food Agric. | pmid:22318921 |
| Deckelbaum RJ and Torrejon C | The omega-3 fatty acid nutritional landscape: health benefits and sources. | 2012 | J. Nutr. | pmid:22323763 |
| Larsen MK et al. | Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. | 2012 | J. Sci. Food Agric. | pmid:22337263 |
| Nieman DC et al. | Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. | 2012 | J Altern Complement Med | pmid:22830971 |
| Angulo J et al. | Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. | 2012 | J. Environ. Manage. | pmid:21784573 |
| Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
| Aliani M et al. | Effect of flax addition on the flavor profile and acceptability of bagels. | 2012 | J. Food Sci. | pmid:22260132 |
| Umesha SS and Naidu KA | Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. | 2012 | Food Chem | pmid:22980881 |
| Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
| Gupta R and Prabhune AA | Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. | 2012 | Biotechnol. Lett. | pmid:22167634 |
| Poudel-Tandukar K et al. | Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. | 2012 | Atherosclerosis | pmid:22153152 |
| Zheng MM et al. | Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. | 2012 | Bioresour. Technol. | pmid:22209442 |
| Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
| Chiu CC et al. | Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. | 2012 | Am. J. Clin. Nutr. | pmid:22218153 |
| Lemaitre RN et al. | Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22743310 |
| Zhang L et al. | Quantitative genomics of 30 complex phenotypes in Wagyu x Angus Fâ‚ progeny. | 2012 | Int. J. Biol. Sci. | pmid:22745575 |
| Fink BD et al. | Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. | 2012 | PLoS ONE | pmid:22745753 |
| Egert S et al. | Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. | 2012 | J. Nutr. | pmid:22810989 |
| Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
| Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
| Pham AT et al. | Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. | 2012 | Theor. Appl. Genet. | pmid:22476873 |
| Rosa DD et al. | Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. | 2012 | Nutr Cancer | pmid:22483364 |
| Karppi J et al. | Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. | 2012 | Nutr Cancer | pmid:22420939 |
| Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
| Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
| Kowalska A et al. | Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). | 2012 | Fish Physiol. Biochem. | pmid:21656178 |
| Ishida Y et al. | Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. | 2012 | J. Agric. Food Chem. | pmid:22458968 |
| Mirmiran P et al. | Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. | 2012 | Nutrition | pmid:22459553 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
| Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
| Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Bocianowski J et al. | Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. | 2012 | J. Appl. Genet. | pmid:21912934 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Erdinest N et al. | Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22669722 |
| Longvah T et al. | Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. | 2012 | J. Sci. Food Agric. | pmid:22290445 |
| Chen CY and Inui A | What kind of polyunsaturated fatty acid should we eat to stay healthy? | 2012 | Nutrition | pmid:22658641 |
| de Freitas JM et al. | Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. | 2012 | FEMS Yeast Res. | pmid:22846157 |
| Gómez-Cortés P et al. | Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. | 2012 | Anal. Chem. | pmid:22662968 |
| Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
| Gerber M | Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. | 2012 | Br. J. Nutr. | pmid:22591896 |
| Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
| Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
| Vyncke KE et al. | Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. | 2012 | Br. J. Nutr. | pmid:22370331 |
| Park HG et al. | Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). | 2012 | J. Agric. Food Chem. | pmid:22372442 |
| Liu HL et al. | Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. | 2012 | J. Exp. Bot. | pmid:22378946 |
| Tu WC et al. | Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities. | 2012 | Biotechnol. Lett. | pmid:22391738 |
| Caspar-Bauguil S et al. | Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. | 2012 | Clin Nutr | pmid:22385730 |
| Gorissen L et al. | Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. | 2012 | Int. J. Food Microbiol. | pmid:22405353 |
| Shinohara N et al. | jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. | 2012 | J Oleo Sci | pmid:22864514 |
| Román à et al. | Contribution of the different omega-3 fatty acid desaturase genes to the cold response in soybean. | 2012 | J. Exp. Bot. | pmid:22865909 |
| Griffin BA | Goldilocks and the three bonds: new evidence for the conditional benefits of dietary α-linolenic acid in treating cardiovascular risk in the metabolic syndrome. | 2012 | Br. J. Nutr. | pmid:22894910 |
| Baxheinrich A et al. | Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. | 2012 | Br. J. Nutr. | pmid:22894911 |
| Nam KH and Yoshihara T | Interactions among LOX metabolites regulate temperature-mediated flower bud formation in morning glory (Pharbitis nil). | 2012 | J. Plant Physiol. | pmid:22902207 |
| Evans SJ et al. | Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. | 2012 | J Psychiatr Res | pmid:22884424 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Pan H et al. | Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. | 2012 | Neurotoxicology | pmid:22884490 |
| Huan M et al. | In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878199 |
| Santos FS et al. | Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. | 2012 | J Pediatr Adolesc Gynecol | pmid:22840939 |