MeSH term | MeSH ID | Detail |
---|---|---|
Irritable Bowel Syndrome | D043183 | 8 associated lipids |
Overweight | D050177 | 11 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sugasini D and Lokesh BR | Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. | 2012 | Lipids | pmid:23104428 |
Jung DM et al. | Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. | 2012 | J. Food Sci. | pmid:23106331 |
Pereira H et al. | Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. | 2012 | Mar Drugs | pmid:23118712 |
Fang XL et al. | Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. | 2012 | Mol. Biol. Rep. | pmid:23053988 |
He ML et al. | Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. | 2012 | Lipids | pmid:23054550 |
Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
Saha SS et al. | Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. | 2012 | Biochim. Biophys. Acta | pmid:22967758 |
Kim N and Choe E | Singlet oxygen-related photooxidative stability and antioxidant changes of diacylglycerol-rich oil derived from mixture of olive and perilla oil. | 2012 | J. Food Sci. | pmid:23057833 |
Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
He ML et al. | Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. | 2012 | J. Anim. Sci. | pmid:22274861 |
Sun T et al. | Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. | 2012 | J. Sci. Food Agric. | pmid:22318921 |
Deckelbaum RJ and Torrejon C | The omega-3 fatty acid nutritional landscape: health benefits and sources. | 2012 | J. Nutr. | pmid:22323763 |
Larsen MK et al. | Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. | 2012 | J. Sci. Food Agric. | pmid:22337263 |
Angulo J et al. | Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. | 2012 | J. Environ. Manage. | pmid:21784573 |
Pirat C et al. | Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. | 2012 | J. Med. Chem. | pmid:22260081 |
Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
Gaquerel E et al. | Nicotiana attenuata α-DIOXYGENASE1 through its production of 2-hydroxylinolenic acid is required for intact plant defense expression against attack from Manduca sexta larvae. | 2012 | New Phytol. | pmid:22937952 |
Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
Aliani M et al. | Effect of flax addition on the flavor profile and acceptability of bagels. | 2012 | J. Food Sci. | pmid:22260132 |
Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
Kuhns EH et al. | A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. | 2012 | Insect Biochem. Mol. Biol. | pmid:22056272 |
Karppi J et al. | Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. | 2012 | Nutr Cancer | pmid:22420939 |
Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
Ishida Y et al. | Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. | 2012 | J. Agric. Food Chem. | pmid:22458968 |
Mirmiran P et al. | Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. | 2012 | Nutrition | pmid:22459553 |
Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
Miyake Y et al. | Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. | 2012 | Nutr J | pmid:22449171 |
Nakamura YK et al. | Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. | 2012 | Food Chem. Toxicol. | pmid:22490668 |
Zhang LH et al. | [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. | 2012 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22493899 |
Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
Luo ZM et al. | A new norisoprenoid and other compounds from Fuzhuan brick tea. | 2012 | Molecules | pmid:22430120 |
Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
Longvah T et al. | Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. | 2012 | J. Sci. Food Agric. | pmid:22290445 |
Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
Evans SJ et al. | Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. | 2012 | J Psychiatr Res | pmid:22884424 |
Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
Pan H et al. | Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. | 2012 | Neurotoxicology | pmid:22884490 |
Huan M et al. | In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878199 |
Zhang G et al. | [Effects of fatty acids on proliferation and differentiation of myoblast]. | 2012 | Wei Sheng Yan Jiu | pmid:23424861 |
Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
Hofacer R et al. | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047910 |
Tsuzuki W | Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. | 2012 Nov-Dec | J AOAC Int | pmid:23451392 |
Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
Zheng JS et al. | Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. | 2013 | BMJ | pmid:23814120 |
Almario RU and Karakas SE | Lignan content of the flaxseed influences its biological effects in healthy men and women. | 2013 | J Am Coll Nutr | pmid:23885993 |
Stivala S et al. | Dietary α-linolenic acid increases the platelet count in ApoE-/- mice by reducing clearance. | 2013 | Blood | pmid:23801636 |
Pan X et al. | Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissimum L.) seed catalyzing the selective production of trilinolenin. | 2013 | J. Biol. Chem. | pmid:23824186 |
Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
Wang DQ et al. | [Alpha-linolenic acid improves insulin sensitivity in obese patients]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23648351 |
Oh HJ et al. | Production of 10-hydroxy-12,15(Z,Z)-octadecadienoic acid from α-linolenic acid by permeabilized cells of recombinant Escherichia coli expressing the oleate hydratase gene of Stenotrophomonas maltophilia. | 2013 | Biotechnol. Lett. | pmid:23690042 |
Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
Sengupta A and Ghosh M | Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. | 2013 | Indian J. Exp. Biol. | pmid:23678545 |
Rao CV et al. | Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. | 2013 | Nutr Cancer | pmid:23682783 |
Hutchins AM et al. | Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. | 2013 | Nutr Res | pmid:23684438 |
Simon MC et al. | Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes. | 2013 | Clin. Exp. Immunol. | pmid:23600826 |
Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
Gregory MK et al. | Functional characterization of the chicken fatty acid elongases. | 2013 | J. Nutr. | pmid:23173174 |
Tu WC et al. | Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23085323 |
Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
Poudyal H et al. | Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23026492 |
Yang YX et al. | Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. | 2013 | Animal | pmid:23031206 |
Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
Egusa Saiga A and Nishimura T | Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200778 |
Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
Afitlhile M et al. | A mutant of the Arabidopsis thaliana TOC159 gene accumulates reduced levels of linolenic acid and monogalactosyldiacylglycerol. | 2013 | Plant Physiol. Biochem. | pmid:24184455 |
Ma T et al. | Effect of droplet size on autoxidation rates of methyl linoleate and α-linolenate in an oil-in-water emulsion. | 2013 | J Oleo Sci | pmid:24292352 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
Sonne DP and Knop FK | Cardiovascular effects of alpha-linolenic acid--a possible role of glucagon-like peptide-1. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24174423 |
Hoque M et al. | Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. | 2013 | PLoS ONE | pmid:24039698 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
Arya E et al. | Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats. | 2013 | Biomed Res Int | pmid:24027769 |
Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
Niculescu MD et al. | Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. | 2013 | FASEB J. | pmid:22997227 |
Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
Shin JA et al. | Preparation of recombined milk using modified butterfats containing α-linolenic acid. | 2013 | J. Food Sci. | pmid:23278855 |
Yang D et al. | Antioxidative activities of Ginkgo biloba extract on oil/water emulsion system prepared from an enzymatically modified lipid containing alpha-linolenic acid. | 2013 | J. Food Sci. | pmid:23278764 |
Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
Esselburn KM et al. | Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. | 2013 | J. Dairy Sci. | pmid:23810586 |