MeSH term | MeSH ID | Detail |
---|---|---|
Irritable Bowel Syndrome | D043183 | 8 associated lipids |
Overweight | D050177 | 11 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
Howlett NG and Avery SV | Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. | 1997 | Appl. Environ. Microbiol. | pmid:9251184 |
Huang MZ et al. | Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats. | 1997 | Lipids | pmid:9252963 |
Gatchalian-Yee M et al. | Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. | 1997 Jul-Aug | Nutrition | pmid:9263255 |
Poon WW et al. | Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants. | 1997 | Mol. Aspects Med. | pmid:9266513 |
Kudo N and Kawashima Y | Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9266801 |
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Tomioka H et al. | Effector molecules of the host defence mechanism against Mycobacterium avium complex: the evidence showing that reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids each alone are not decisive in expression of macrophage antimicrobial activity against the parasites. | 1997 | Clin. Exp. Immunol. | pmid:9276519 |
Okuno M et al. | Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. | 1997 | J. Nutr. | pmid:9278555 |
Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
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Hall JA et al. | Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. | 1997 Jul-Aug | J. Vet. Intern. Med. | pmid:9298479 |
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Kim KS et al. | Dietary alpha-linolenic acid increases the biosynthesis of the choline glycerophospholipids from [14C]CDPcholine in rat liver and kidney but not in brain. | 1997 | Neurochem. Res. | pmid:9342734 |
Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
Sakamoto T et al. | Alteration of low-temperature susceptibility of the cyanobacterium Synechococcus sp. PCC 7002 by genetic manipulation of membrane lipid unsaturation. | 1998 | Arch. Microbiol. | pmid:9396831 |
van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
Lu Z et al. | Low linolenate and commercial soybean oils diminish serum HDL cholesterol in young free-living adult females. | 1997 | J Am Coll Nutr | pmid:9430084 |
Schimke I et al. | Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431820 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
Zimmer L et al. | Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. | 1998 | Neurosci. Lett. | pmid:9502233 |
Bretillon L et al. | Oxidative metabolism of [1-14C] mono-trans isomers of linoleic and alpha-linolenic acids in the rat. | 1998 | Biochim. Biophys. Acta | pmid:9507133 |
Pähkla R et al. | Comparison of the antioxidant activity of melatonin and pinoline in vitro. | 1998 | J. Pineal Res. | pmid:9510434 |
Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
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Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
Prasad K et al. | Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. | 1998 | Atherosclerosis | pmid:9543108 |
Edwards R et al. | Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. | 1998 | J Affect Disord | pmid:9543204 |
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Yehuda S et al. | Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. | 1998 | Neurochem. Res. | pmid:9566600 |
De Stefani E et al. | Essential fatty acids and breast cancer: a case-control study in Uruguay. | 1998 | Int. J. Cancer | pmid:9590123 |
Dokko RC et al. | Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. | 1998 | Int. J. Biochem. Cell Biol. | pmid:9597754 |
Chavali SR et al. | Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610840 |
Iritani N et al. | Lipogenic enzyme gene expression is quickly suppressed in rats by a small amount of exogenous polyunsaturated fatty acids. | 1998 | J. Nutr. | pmid:9614155 |
Ikeda I et al. | Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9614698 |
Peterson LD et al. | Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. | 1998 | Life Sci. | pmid:9627080 |
Okuno M et al. | Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. | 1998 | Nutr Cancer | pmid:9631489 |
Vartak S et al. | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. | 1998 | Br. J. Cancer | pmid:9635836 |
Gerster H | Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? | 1998 | Int J Vitam Nutr Res | pmid:9637947 |
Weisinger HS et al. | Effect of diet on the rate of depletion of n-3 fatty acids in the retina of the guinea pig. | 1998 | J. Lipid Res. | pmid:9643359 |
Howe PR | Omega 3 fatty acids--an Australian perspective. | 1998 | World Rev Nutr Diet | pmid:9648518 |
Jayatilleke A and Shaw S | Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. | 1998 | Alcohol | pmid:9665313 |
Yamada N et al. | Changes in platelet aggregation and lipid metabolism in rats given dietary lipids containing different n-3 polyunsaturated fatty acids. | 1998 | J. Nutr. Sci. Vitaminol. | pmid:9675708 |
Colquhoun A | Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells. | 1998 | Biochem. Mol. Biol. Int. | pmid:9678254 |
Schwab US et al. | The effect of quality and amount of dietary fat on the susceptibility of low density lipoprotein to oxidation in subjects with impaired glucose tolerance. | 1998 | Eur J Clin Nutr | pmid:9683400 |
Suzuki H et al. | Long-term effect of a trace amount of tea catechins with perilla oil on the plasma lipids in mice. | 1998 | Int J Vitam Nutr Res | pmid:9706503 |
Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
Yu G et al. | Fatty acid composition in colostrum and mature milk from non-atopic and atopic mothers during the first 6 months of lactation. | 1998 | Acta Paediatr. | pmid:9722244 |
Belzung C et al. | Alpha-linolenic acid deficiency modifies distractibility but not anxiety and locomotion in rats during aging. | 1998 | J. Nutr. | pmid:9732316 |
Menard CR et al. | Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. | 1998 | J. Neurochem. | pmid:9798942 |
Bretillon L et al. | Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. | 1998 | J. Lipid Res. | pmid:9799809 |
Furuno K et al. | Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. | 1998 | Pharmacol. Toxicol. | pmid:9820879 |
Pang D et al. | Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. | 1998 | Br. J. Nutr. | pmid:9828757 |
Parchmann S and Mueller MJ | Evidence for the formation of dinor isoprostanes E1 from alpha-linolenic acid in plants. | 1998 | J. Biol. Chem. | pmid:9830005 |
Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
Hamberg M | A pathway for biosynthesis of divinyl ether fatty acids in green leaves. | 1998 | Lipids | pmid:9870900 |
Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
Allman-Farinelli MA et al. | Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. | 1999 | Atherosclerosis | pmid:9920517 |
Tranchant T et al. | Long-term supplementation of culture medium with essential fatty acids alters alpha-linolenic acid uptake in Caco-2 clone TC7. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9923400 |
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Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
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