MeSH term | MeSH ID | Detail |
---|---|---|
Amyloidosis | D000686 | 4 associated lipids |
Adrenoleukodystrophy | D000326 | 29 associated lipids |
Adenoma | D000236 | 40 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Francès H et al. | Influence of a dietary alpha-linolenic acid deficiency on learning in the Morris water maze and on the effects of morphine. | 1996 | Eur. J. Pharmacol. | pmid:8846819 |
Venuta A et al. | Essential fatty acids: the effects of dietary supplementation among children with recurrent respiratory infections. | 1996 Jul-Aug | J. Int. Med. Res. | pmid:8854285 |
Hudson JA et al. | Hydration of oleic acid by a Selenomonas strain from the ovine rumen. | 1996 | Lett. Appl. Microbiol. | pmid:8862016 |
Inui K et al. | The effect of alpha-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8862700 |
Schingoethe DJ et al. | Lactational responses of dairy cows fed unsaturated fat from extruded soybeans or sunflower seeds. | 1996 | J. Dairy Sci. | pmid:8872718 |
Leece EA and Allman MA | The relationships between dietary alpha-linolenic:linoleic acid and rat platelet eicosapentaenoic and arachidonic acids. | 1996 | Br. J. Nutr. | pmid:8881716 |
Inui K et al. | The nutritional effect of a-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8886251 |
Ferretti A and Flanagan VP | Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888358 |
Ovesen L et al. | The effect of microwave heating on vitamins B1 and E, and linoleic and linolenic acids, and immunoglobulins in human milk. | 1996 | Int J Food Sci Nutr | pmid:8889628 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Klein AS et al. | Allopurinol: discrimination of antioxidant from enzyme inhibitory activities. | 1996 | Free Radic. Biol. Med. | pmid:8891675 |
Conconi A et al. | The octadecanoid signalling pathway in plants mediates a response to ultraviolet radiation. | 1996 | Nature | pmid:8893008 |
Scheideler SE and Froning GW | The combined influence of dietary flaxseed variety, level, form, and storage conditions on egg production and composition among vitamin E-supplemented hens. | 1996 | Poult. Sci. | pmid:8893298 |
Kawano Y and Noma T | Inhibition by lecithin-bound iodine (LBI) of inducible allergen-specific T lymphocytes' responses in allergic diseases. | 1996 | Int. J. Immunopharmacol. | pmid:8894803 |
Rupp H et al. | Dietary linolenic acid-mediated increase in vascular prostacyclin formation. | 1996 | Mol. Cell. Biochem. | pmid:8905626 |
Cunnane SC | The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909772 |
Cunnane SC and Likhodii SS | 13C NMR spectroscopy and gas chromatograph--combustion--isotope ratio mass spectrometry: complementary applications in monitoring the metabolism of 13C-labelled polyunsaturated fatty acids. | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909789 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Mensink R | Essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925181 |
Mutanen M and Freese R | Polyunsaturated fatty acids and platelet aggregation. | 1996 | Curr. Opin. Lipidol. | pmid:8925182 |
Sugano M and Ikeda I | Metabolic interactions between essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925188 |
Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Howe GA et al. | An octadecanoid pathway mutant (JL5) of tomato is compromised in signaling for defense against insect attack. | 1996 | Plant Cell | pmid:8953771 |
Kabir Y and Ide T | Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid. | 1996 | Biochim. Biophys. Acta | pmid:8954134 |
Applegate TJ and Sell JL | Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. | 1996 | Poult. Sci. | pmid:8966177 |
Voskuil DW et al. | Intake and sources of alpha-linolenic acid in Dutch elderly men. | 1996 | Eur J Clin Nutr | pmid:8968698 |
Babu US et al. | Impact of in vitro fatty acid uptake on nitric oxide production and antilisterial activity of WEHI-3 cells. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993386 |
Yoshida S et al. | Synaptic vesicle ultrastructural changes in the rat hippocampus induced by a combination of alpha-linolenate deficiency and a learning task. | 1997 | J. Neurochem. | pmid:9048773 |
Das I et al. | Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. | 1997 | Biochem. Soc. Trans. | pmid:9056997 |
Hussey HJ and Tisdale MJ | Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). | 1997 | Br. J. Cancer | pmid:9062405 |
Oh-hashi K et al. | Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. | 1997 | Biol. Pharm. Bull. | pmid:9084876 |
Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
Tranchant T et al. | Mechanisms and kinetics of alpha-linolenic acid uptake in Caco-2 clone TC7. | 1997 | Biochim. Biophys. Acta | pmid:9106494 |
Vinggaard AM et al. | Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. | 1997 | Cell. Signal. | pmid:9113419 |
Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
Wagner W and Nootbaar-Wagner U | Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. | 1997 | Cephalalgia | pmid:9137851 |
Sravan Kumar G and Das UN | Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150374 |
Koga T et al. | Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. | 1997 | Br. J. Nutr. | pmid:9155511 |
Sugihara N et al. | Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid. | 1997 | Toxicology | pmid:9160106 |
Smith GM and Isopenko A | Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160431 |
Hardwick SJ et al. | Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate. | 1997 | Free Radic. Res. | pmid:9167940 |
Guesnet P et al. | Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat. | 1997 | Lipids | pmid:9168459 |
Spitzer V et al. | Structure analysis of an allene-containing estolide tetraester triglyceride in the seed oil of Sebastiana commersoniana (Euphorbiaceae). | 1997 | Lipids | pmid:9168462 |
Jeffery NM et al. | Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. | 1997 | Br. J. Nutr. | pmid:9175999 |
Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
Kokura S et al. | Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. | 1997 | Cancer Res. | pmid:9187121 |
Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
Kelso KA et al. | Effects of dietary supplementation with alpha-linolenic acid on the phospholipid fatty acid composition and quality of spermatozoa in cockerel from 24 to 72 weeks of age. | 1997 | J. Reprod. Fertil. | pmid:9227357 |
Hisha H et al. | Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to. | 1997 | Blood | pmid:9242532 |