alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Liver Diseases D008107 31 associated lipids
Stroke D020521 32 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Epilepsy D004827 35 associated lipids
Heart Failure D006333 36 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Karapanagiotidis IT et al. Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh. 2007 Lipids pmid:17473942
Ishihara K et al. Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. 2002 Lipids pmid:12056590
Sugasini D and Lokesh BR Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. 2012 Lipids pmid:23104428
Zainal Z et al. Modification of palm oil for anti-inflammatory nutraceutical properties. 2009 Lipids pmid:19449050
Sioen I et al. Effect of ALA-enriched food supply on cardiovascular risk factors in males. 2009 Lipids pmid:19452183
Taha AY et al. Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. 2006 Lipids pmid:17180881
Torstensen BE and Stubhaug I Beta-oxidation of 18:3n-3 in Atlantic salmon (Salmo salar L.) hepatocytes treated with different fatty acids. 2004 Lipids pmid:15134142
Delmonte P et al. Synthesis, isolation, and GC analysis of all the 6,8- to 13,15-cis/trans conjugated linoleic acid isomers. 2004 Lipids pmid:15134147
Katrangi W et al. Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. 2013 Lipids pmid:23440519
Harauma A et al. Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition. 2010 Lipids pmid:20625936
Grandgirard A et al. Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. 1994 Lipids pmid:7909911
Tsuzuki T et al. Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and alpha-tocopherol. 2004 Lipids pmid:15506243
Vaysse-Boué C et al. Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. 2007 Lipids pmid:17564735
Alessandri JM et al. Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. 2008 Lipids pmid:17912567
Watkins SM et al. Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. 2001 Lipids pmid:11337979
Fu Z and Sinclair AJ Increased alpha-linolenic acid intake increases tissue alpha-linolenic acid content and apparent oxidation with little effect on tissue docosahexaenoic acid in the guinea pig. 2000 Lipids pmid:10858024
Nomura T et al. A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. 2001 Life Sci. pmid:11432454
Frances H et al. Effect of dietary alpha-linolenic acid deficiency on habituation. 1996 Life Sci. pmid:8637406
Pisanti FA et al. Effects of bonellin on lipids. 1986 Life Sci. pmid:2869393
Peterson LD et al. Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. 1998 Life Sci. pmid:9627080
Yao HT et al. The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. 2006 Life Sci. pmid:16978661
Miyazawa D et al. Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. 2003 Life Sci. pmid:12899931
Francès H et al. Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice. 1995 Life Sci. pmid:7475943
Miyazawa D et al. Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. 2010 Life Sci. pmid:20837030
Kim HK and Choi H Stimulation of acyl-CoA oxidase by alpha-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats. 2005 Life Sci. pmid:15894339
Vijaimohan K et al. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. 2006 Life Sci. pmid:16490217
Hudson JA et al. Hydration of oleic acid by a Selenomonas strain from the ovine rumen. 1996 Lett. Appl. Microbiol. pmid:8862016
Xian M et al. Production of gamma-linolenic acid by Mortierella isabellina grown on hexadecanol. 2001 Lett. Appl. Microbiol. pmid:11696098
Gage SH et al. Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. 2013 Langmuir pmid:23234434
McKeigue P Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? 1994 Lancet pmid:7911171
de Lorgeril M et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. 1994 Lancet pmid:7911176
Mantzioris E et al. Mediterranean diet. 1994 Lancet pmid:7914327
Cunnane SC and McIntosh D alpha-Linolenic acid and reduction of cardiac deaths. 1994 Lancet pmid:7914995
Marckmann P and Jespersen J alpha-Linolenic acid and reduction of cardiac deaths. 1994 Lancet pmid:7914996
Rice RD Mediterranean diet. 1994 Lancet pmid:7916429
Romans JR Alpha-linolenic acid. 1989 Lancet pmid:2563803
Gibson RA Long-chain polyunsaturated fatty acids and infant development. 1999 Lancet pmid:10622289
Renaud S and Nordøy A "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. 1983 Lancet pmid:6133188
Hashimoto Y et al. Effect of black-pigmented Bacteroides gingivalis on cytotoxic activity of linolenic acid against mouse macrophages. 1989 Kitasato Arch. Exp. Med. pmid:2570177
Narisawa T et al. Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. 1991 Jpn. J. Cancer Res. pmid:1683347
Mori T et al. Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl. 2001 Jpn. J. Cancer Res. pmid:11676852
Pazirandeh S et al. Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. 2007 Nov-Dec JPEN J Parenter Enteral Nutr pmid:17947609
Sakurai T et al. Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas. 2002 Mar-Apr JPEN J Parenter Enteral Nutr pmid:11871742
Usami M et al. Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. 2006 Mar-Apr JPEN J Parenter Enteral Nutr pmid:16517957
Sacks GS et al. Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. 1994 May-Jun JPEN J Parenter Enteral Nutr pmid:7914941
I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? 2006 Johns Hopkins Med Lett Health After 50 pmid:16548073
Del Gobbo LC et al. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. 2016 JAMA Intern Med pmid:27357102
Siguel EN Dietary sources of long-chain n-3 polyunsaturated fatty acids. 1996 JAMA pmid:8596214
Sato I et al. Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. 2007 J. Vet. Med. Sci. pmid:17675801
Hall JA et al. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. 1997 Jul-Aug J. Vet. Intern. Med. pmid:9298479
Hansen RA et al. Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. 2002 Jul-Aug J. Vet. Intern. Med. pmid:12141309
Lang-Lazdunski L et al. Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. 2003 J. Vasc. Surg. pmid:12947278
Fleshner N et al. Dietary fat and prostate cancer. 2004 J. Urol. pmid:14713748
Cohen SL and Ward WE Flaxseed oil and bone development in growing male and female mice. 2005 J. Toxicol. Environ. Health Part A pmid:16207634
Yang JG et al. Determination of the contents of EPA and DHA and lipid constituents in main fresh water fishes in China. 1994 J. Tongji Med. Univ. pmid:7966518
Hanai T et al. Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. 1993 J. Surg. Res. pmid:8094103
Guo Q et al. Highly sensitive method for the quantification of trans-linolenic acid isomers in trilinolenin of edible oils using an ionic liquid capillary column. 2017 J. Sci. Food Agric. pmid:28369919
Ben Youssef N et al. Effect of olive ripeness on chemical properties and phenolic composition of Chétoui virgin olive oil. 2010 J. Sci. Food Agric. pmid:20355031
Szalai G et al. Effect of nitrogen source in the fertilizing solution on nutritional quality of three members of the Portulaca oleracea aggregate. 2010 J. Sci. Food Agric. pmid:20572061
Sun T et al. Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. 2012 J. Sci. Food Agric. pmid:22318921
Larsen MK et al. Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. 2012 J. Sci. Food Agric. pmid:22337263
Berasategi I et al. Reduced-fat bologna sausages with improved lipid fraction. 2014 J. Sci. Food Agric. pmid:24105447
Baars T et al. Experimental improvement of cow milk fatty acid composition in organic winter diets. 2012 J. Sci. Food Agric. pmid:22173628
Padmashree A et al. Studies on the antioxygenic activity of bitter gourd (Momordica charantia) and its fractions using various in vitro models. 2011 J. Sci. Food Agric. pmid:21302334
Longvah T et al. Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. 2012 J. Sci. Food Agric. pmid:22290445
Kelso KA et al. Effects of dietary supplementation with alpha-linolenic acid on the phospholipid fatty acid composition and quality of spermatozoa in cockerel from 24 to 72 weeks of age. 1997 J. Reprod. Fertil. pmid:9227357
Moriyama R et al. Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. 2016 J. Reprod. Dev. pmid:26853521
Nam KH and Yoshihara T Interactions among LOX metabolites regulate temperature-mediated flower bud formation in morning glory (Pharbitis nil). 2012 J. Plant Physiol. pmid:22902207
Pähkla R et al. Comparison of the antioxidant activity of melatonin and pinoline in vitro. 1998 J. Pineal Res. pmid:9510434
Yadav S et al. Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features. 2017 J. Physiol. Biochem. pmid:27878518
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Caffieri S et al. Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. 1994 J. Photochem. Photobiol. B, Biol. pmid:7912265
Takahara Y et al. Pharmacogenomics of cardiovascular pharmacology: development of an informatics system for analysis of DNA microarray data with a focus on lipid metabolism. 2008 J. Pharmacol. Sci. pmid:18490852
Sugihara N et al. High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. 1995 J. Pharmacol. Exp. Ther. pmid:7616398
Trommer H et al. Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action. 2003 J. Pharm. Pharmacol. pmid:14607020
Uauy R Are omega-3 fatty acids required for normal eye and brain development in the human? 1990 J. Pediatr. Gastroenterol. Nutr. pmid:1978859
McClead RE et al. The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1676411
Agostoni C et al. Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:17204967
Hsieh JC et al. High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. 2015 J. Pediatr. Gastroenterol. Nutr. pmid:25633498
Rhodes PG et al. Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1681044
Field CJ et al. Effect of feeding a formula supplemented with long-chain polyunsaturated fatty acids for 14 weeks improves the ex vivo response to a mitogen and reduces the response to a soy protein in infants at low risk for allergy. 2010 J. Pediatr. Gastroenterol. Nutr. pmid:20386325
Sauerwald UC et al. Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22008957
McClead RE et al. Comparison of the clinical and biochemical effect of increased alpha-linolenic acid in a safflower oil intravenous fat emulsion. 1985 J. Pediatr. Gastroenterol. Nutr. pmid:2859362
Luukkainen P et al. Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. 1996 J. Pediatr. Gastroenterol. Nutr. pmid:8890071
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Byrne WJ Intralipid or Liposyn--comparable products? 1982 J. Pediatr. Gastroenterol. Nutr. pmid:6310073
Lapillonne A et al. Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. 2000 J. Pediatr. Gastroenterol. Nutr. pmid:10817283
Ratnayake WM et al. Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. 1997 J. Pediatr. Gastroenterol. Nutr. pmid:9327370
Lapillonne A et al. Plausible mechanisms for effects of long-chain polyunsaturated fatty acids on growth. 2003 J. Pediatr. pmid:14597909
Uauy R et al. Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. 1994 J. Pediatr. pmid:7908693
Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
Ainai T et al. Efficient total synthesis of 12-oxo-PDA and OPC-8:0. 2003 J. Org. Chem. pmid:14510562
Yamada N et al. Changes in platelet aggregation and lipid metabolism in rats given dietary lipids containing different n-3 polyunsaturated fatty acids. 1998 J. Nutr. Sci. Vitaminol. pmid:9675708
Nakashima Y et al. Effect of plant- and fish-oil derived n-3 polyunsaturated fatty acids on counteraction of n-3 fatty acid shortage in adult rats fed a lard diet. 2009 J. Nutr. Sci. Vitaminol. pmid:19763036
Watanabe T et al. Immobilization of lipases on polyethylene and application to perilla oil hydrolysis for production of alpha-linolenic acid. 1995 J. Nutr. Sci. Vitaminol. pmid:7472675
Fujiyama-Fujiwara Y et al. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. 1995 J. Nutr. Sci. Vitaminol. pmid:7562115
Noguchi A et al. Effects of casein and soy-protein on alpha-linolenic acid metabolism in rats. 1992 J. Nutr. Sci. Vitaminol. pmid:1363922