| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neuroblastoma | D009447 | 66 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim H et al. | Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. | 2003 | J. Biochem. Mol. Biol. | pmid:12787479 |
| Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
| Maruyama C et al. | Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome. | 2008 | J. Atheroscler. Thromb. | pmid:19060426 |
| Veshkini A et al. | Effect of Linolenic acid during in vitro maturation of ovine oocytes: embryonic developmental potential and mRNA abundances of genes involved in apoptosis. | 2015 | J. Assist. Reprod. Genet. | pmid:25715790 |
| Kishino S et al. | Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. | 2010 | J. Appl. Microbiol. | pmid:19919619 |
| Gorissen L et al. | Linoleate isomerase activity occurs in lactic acid bacteria strains and is affected by pH and temperature. | 2011 | J. Appl. Microbiol. | pmid:21699633 |
| Bocianowski J et al. | Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. | 2012 | J. Appl. Genet. | pmid:21912934 |
| Alvarado-Gilis CA et al. | Effects of feeding diets rich in α-linolenic acid and copper on performance, carcass characteristics, and fatty acid profiles of feedlot heifers. | 2014 | J. Anim. Sci. | pmid:25414107 |
| Eastwood L et al. | Changing the omega-6 to omega-3 fatty acid ratio in sow diets alters serum, colostrum, and milk fatty acid profiles, but has minimal impact on reproductive performance. | 2014 | J. Anim. Sci. | pmid:25403193 |
| Specht-Overholt S et al. | Fatty acid composition of commercially manufactured omega-3 enriched pork products, haddock, and mackerel. | 1997 | J. Anim. Sci. | pmid:9303450 |
| Coates W and Ayerza R | Chia (Salvia hispanica L.) seed as an n-3 fatty acid source for finishing pigs: effects on fatty acid composition and fat stability of the meat and internal fat, growth performance, and meat sensory characteristics. | 2009 | J. Anim. Sci. | pmid:19648503 |
| Waylan AT et al. | Effect of flax supplementation and growth promotants on lipoprotein lipase and glycogenin messenger RNA concentrations in finishing cattle. | 2004 | J. Anim. Sci. | pmid:15217016 |
| Dunn JD et al. | Effects of flax supplementation and a combined trenbolone acetate and estradiol implant on circulating insulin-like growth factor-I and muscle insulin-like growth factor-I messenger RNA levels in beef cattle. | 2003 | J. Anim. Sci. | pmid:14677858 |
| Kouba M et al. | Effect of a high-linolenic acid diet on lipogenic enzyme activities, fatty acid composition, and meat quality in the growing pig. | 2003 | J. Anim. Sci. | pmid:12926779 |
| MartÃnez-RamÃrez HR et al. | Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs. | 2014 | J. Anim. Sci. | pmid:24305874 |
| Lee JH et al. | Feeding encapsulated ground full-fat soybeans to increase polyunsaturated fat concentrations and effects on flavor volatiles in fresh lamb. | 2004 | J. Anim. Sci. | pmid:15446490 |
| He ML et al. | Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. | 2012 | J. Anim. Sci. | pmid:22274861 |
| Fincham JR et al. | Fatty acid metabolism and deposition in subcutaneous adipose tissue of pasture- and feedlot-finished cattle. | 2009 | J. Anim. Sci. | pmid:19617512 |
| Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. | 1995 | J. Anim. Sci. | pmid:7592082 |
| Li XZ et al. | Dietary linseed oil with or without malate increases conjugated linoleic acid and oleic acid in milk fat and and gene expression in mammary gland and milk somatic cells of lactating goats. | 2016 | J. Anim. Sci. | pmid:27695785 |
| Lee Y et al. | Alpha-linolenic acid treatment during oocyte maturation enhances embryonic development by influencing mitogen-activated protein kinase activity and intraoocyte glutathione content in pigs. | 2016 | J. Anim. Sci. | pmid:27695771 |
| Kronberg SL et al. | Treatment of flaxseed to reduce biohydrogenation of α-linolenic acid by ruminal microbes in sheep and cattle, and increase n-3 fatty acid concentrations in red meat. | 2012 | J. Anim. Sci. | pmid:22696616 |
| Campidonico L et al. | Fatty acid composition of ruminal digesta and longissimus muscle from lambs fed silage mixtures including red clover, sainfoin, and timothy. | 2016 | J. Anim. Sci. | pmid:27136014 |
| Wright AM et al. | Effect of forage type with or without corn supplementation on animal performance, beef fatty acid composition, and palatability. | 2015 | J. Anim. Sci. | pmid:26523597 |
| Hejazi L et al. | Discrimination among geometrical isomers of alpha-linolenic acid methyl ester using low energy electron ionization mass spectrometry. | 2009 | J. Am. Soc. Mass Spectrom. | pmid:19318230 |
| Araujo P et al. | Chemometric approaches in calibration experiments of trilinolenoylglycerol by liquid chromatography ion-trap mass spectrometry. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15734332 |
| Djoussé L et al. | Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. | 2005 | J. Am. Coll. Cardiol. | pmid:15893192 |
| Pratt DA et al. | Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. | 2003 | J. Am. Chem. Soc. | pmid:12733921 |
| Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
| Herdmann A et al. | Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing. | 2010 | J. Agric. Food Chem. | pmid:20597504 |
| Wang S and Zhang A | Facile and efficient syntheses of (3Z,6Z,9Z)-3,6,9-nonadecatriene and homologues: pheromone and attractant components of lepidoptera. | 2007 | J. Agric. Food Chem. | pmid:17661482 |
| Anwar F et al. | Analytical characterization of Salicornia bigelovii seed oil cultivated in Pakistan. | 2002 | J. Agric. Food Chem. | pmid:12105947 |
| Padilla MN et al. | Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19722522 |
| Shanker KS et al. | Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves. | 2006 | J. Agric. Food Chem. | pmid:16637689 |
| Myung K et al. | Interaction with and effects on the profile of proteins of Botrytis cinerea by C6 aldehydes. | 2007 | J. Agric. Food Chem. | pmid:17323971 |
| Zhao ML et al. | Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. | 2013 | J. Agric. Food Chem. | pmid:23350869 |
| Cantrell CL et al. | Phytotoxic Eremophilanes from Ligularia macrophylla. | 2007 | J. Agric. Food Chem. | pmid:18044832 |
| Molkentin J | Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat. | 2009 | J. Agric. Food Chem. | pmid:19132889 |
| Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
| Kaufman M and Wiesman Z | Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting. | 2007 | J. Agric. Food Chem. | pmid:18004807 |
| Raes K et al. | Effect of diet and dietary fatty acids on the transformation and incorporation of C18 fatty acids in double-muscled Belgian Blue young bulls. | 2004 | J. Agric. Food Chem. | pmid:15366860 |
| Sánchez-Ortiz A et al. | Cultivar differences on nonesterified polyunsaturated fatty acid as a limiting factor for the biogenesis of virgin olive oil aroma. | 2007 | J. Agric. Food Chem. | pmid:17708640 |
| Morel C et al. | Isoflavones as potentiators of antibacterial activity. | 2003 | J. Agric. Food Chem. | pmid:12952418 |
| Destaillats F et al. | Metabolites of conjugated isomers of alpha-linolenic acid (CLnA) in the rat. | 2005 | J. Agric. Food Chem. | pmid:15740017 |
| Liu CG et al. | Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan. | 2005 | J. Agric. Food Chem. | pmid:15740066 |
| Anadon A et al. | A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats. | 2011 | J. Agric. Food Chem. | pmid:21678997 |
| Kwon TY et al. | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. | 2013 | J. Agric. Food Chem. | pmid:23968142 |
| Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
| Pérez-Gilabert M et al. | Purification and partial characterization of lipoxygenase from desert truffle (Terfezia claveryi Chatin) ascocarps. | 2005 | J. Agric. Food Chem. | pmid:15853417 |
| Sánchez-Bel P et al. | Oil quality and sensory evaluation of almond (Prunus amygdalus) stored after electron beam processing. | 2005 | J. Agric. Food Chem. | pmid:15796596 |
| Nielsen GS et al. | Formation of volatile compounds in model experiments with crude leek (Allium ampeloprasum Var. Lancelot) enzyme extract and linoleic acid or linolenic acid. | 2004 | J. Agric. Food Chem. | pmid:15080639 |
| Tsydendambaev VD and Vereshchagin AG | Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. | 2003 | J. Agric. Food Chem. | pmid:12590468 |
| Beck JJ et al. | Generation of the volatile spiroketals conophthorin and chalcogran by fungal spores on polyunsaturated fatty acids common to almonds and pistachios. | 2012 | J. Agric. Food Chem. | pmid:23153034 |
| Clapham WM et al. | Fatty acid composition of traditional and novel forages. | 2005 | J. Agric. Food Chem. | pmid:16366696 |
| Zilkowski BW et al. | Analysis of 2,4,6-nonatrienal geometrical isomers from male flea beetles, Epitrix hirtipennis and E. fuscula. | 2008 | J. Agric. Food Chem. | pmid:18553913 |
| Castelli F et al. | Biomimesis of linolenic acid transport through model lipidic membranes by differential scanning calorimetry. | 2003 | J. Agric. Food Chem. | pmid:12568537 |
| Niewitetzki O et al. | A new near-infrared reflectance spectroscopy method for high-throughput analysis of oleic acid and linolenic acid content of single seeds in oilseed rape (Brassica napus L.). | 2010 | J. Agric. Food Chem. | pmid:19961144 |
| Whent M et al. | Effect of genotype, environment, and their interaction on chemical composition and antioxidant properties of low-linolenic soybeans grown in Maryland. | 2009 | J. Agric. Food Chem. | pmid:19817459 |
| Salas JJ et al. | Impact of the suppression of lipoxygenase and hydroperoxide lyase on the quality of the green odor in green leaves. | 2005 | J. Agric. Food Chem. | pmid:15740054 |
| Lin MY and Yen CL | Inhibition of lipid peroxidation by Lactobacillus acidophilus and Bifidobacterium longum. | 1999 | J. Agric. Food Chem. | pmid:10552700 |
| Schuh C and Schieberle P | Characterization of (E,E,Z)-2,4,6-nonatrienal as a character impact aroma compound of oat flakes. | 2005 | J. Agric. Food Chem. | pmid:16248574 |
| Leone A et al. | Lipoxygenase involvement in ripening strawberry. | 2006 | J. Agric. Food Chem. | pmid:16939347 |
| Ulkowski M et al. | Use of differential scanning calorimetry to study lipid oxidation. 1. Oxidative stability of lecithin and linolenic acid. | 2005 | J. Agric. Food Chem. | pmid:16277404 |
| Dobson G et al. | Comparison of fatty acid and polar lipid contents of tubers from two potato species, Solanum tuberosum and Solanum phureja. | 2004 | J. Agric. Food Chem. | pmid:15453705 |
| Liu Q et al. | Influence of linolenic acid content on the oxidation of milk fat. | 2010 | J. Agric. Food Chem. | pmid:20175540 |
| Fukushige H and Hildebrand DF | A simple and efficient system for green note compound biogenesis by use of certain lipoxygenase and hydroperoxide lyase sources. | 2005 | J. Agric. Food Chem. | pmid:16104814 |
| Bendall JG | Aroma compounds of fresh milk from New Zealand cows fed different diets. | 2001 | J. Agric. Food Chem. | pmid:11600029 |
| Elmore JS et al. | Effect of the polyunsaturated fatty acid composition of beef muscle on the profile of aroma volatiles. | 1999 | J. Agric. Food Chem. | pmid:10564028 |
| Liu CG et al. | Linolenic acid-modified chitosan for formation of self-assembled nanoparticles. | 2005 | J. Agric. Food Chem. | pmid:15656685 |
| Nitsan Z et al. | Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. | 1999 | J. Agric. Food Chem. | pmid:10606584 |
| Parry J et al. | Fatty acid composition and antioxidant properties of cold-pressed marionberry, boysenberry, red raspberry, and blueberry seed oils. | 2005 | J. Agric. Food Chem. | pmid:15686403 |
| Tritt KL et al. | Chemometric discrimination among wild and cultured age-0 largemouth bass, black crappies, and white crappies based on fatty acid composition. | 2005 | J. Agric. Food Chem. | pmid:15969511 |
| Ishida Y et al. | Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. | 2012 | J. Agric. Food Chem. | pmid:22458968 |
| Manthey FA et al. | Processing and cooking effects on lipid content and stability of alpha-linolenic acid in spaghetti containing ground flaxseed. | 2002 | J. Agric. Food Chem. | pmid:11879055 |
| Angerosa F et al. | Virgin olive oil volatile compounds from lipoxygenase pathway and characterization of some italian cultivars. | 1999 | J. Agric. Food Chem. | pmid:10552376 |
| Lee JY et al. | Antimicrobial synergistic effect of linolenic acid and monoglyceride against Bacillus cereus and Staphylococcus aureus. | 2002 | J. Agric. Food Chem. | pmid:11902977 |
| Zamora R et al. | Contribution of pyrrole formation and polymerization to the nonenzymatic browning produced by amino-carbonyl reactions. | 2000 | J. Agric. Food Chem. | pmid:10956084 |
| Park HG et al. | Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). | 2012 | J. Agric. Food Chem. | pmid:22372442 |
| Ren J and Chung SH | Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. | 2007 | J. Agric. Food Chem. | pmid:17542608 |
| Senadheera SD et al. | Effects of dietary α-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). | 2011 | J. Agric. Food Chem. | pmid:21222433 |
| Cao Y et al. | Identification and characterization of conjugated linolenic acid isomers by Ag+-HPLC and NMR. | 2006 | J. Agric. Food Chem. | pmid:17117784 |
| Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
| Furono K et al. | Effects of metal ions on lipid peroxidation in cultured rat hepatocytes loaded with alpha-linolenic acid. | 1996 | J Toxicol Environ Health | pmid:8642620 |
| Kreider RB et al. | Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. | 2002 | J Strength Cond Res | pmid:12173945 |
| Able JA et al. | Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. | 2014 | J Psychiatr Res | pmid:24360505 |
| Evans SJ et al. | Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. | 2012 | J Psychiatr Res | pmid:22884424 |
| McNamara RK et al. | Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. | 2009 | J Psychiatr Res | pmid:18986658 |
| Kajita M et al. | Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. | 2000 | J Pharm Sci | pmid:10980499 |
| Ruiz-Rodriguez A et al. | Recent trends in the advanced analysis of bioactive fatty acids. | 2010 | J Pharm Biomed Anal | pmid:19525080 |
| Santos FS et al. | Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. | 2012 | J Pediatr Adolesc Gynecol | pmid:22840939 |
| Matsuo T and Yagi K | Interaction between alpha-linolenic acid-enriched oil and ACE inhibitor concerning the decrease in blood pressure in SHR. | 2008 | J Oleo Sci | pmid:18075218 |
| Hernandez LR et al. | Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. | 2015 | J Oleo Sci | pmid:25757437 |
| Reddy YS et al. | Study on Synthesis, Characterization and Antiproliferative Activity of Novel Diisopropylphenyl Esters of Selected Fatty Acids. | 2016 | J Oleo Sci | pmid:26666272 |
| Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
| Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
| Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
| Lodolini EM et al. | Oil Characteristics of Four Palestinian Olive Varieties. | 2017 | J Oleo Sci | pmid:28381771 |
| Ando Y et al. | Alpha Linolenic Acid-enriched Diacylglycerol Enhances Postprandial Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trail. | 2016 | J Oleo Sci | pmid:27430386 |
| Saito S et al. | Consumption of alpha-Linolenic Acid-enriched Diacylglycerol Reduces Visceral Fat Area in Overweight and Obese Subjects: a Randomized, Double-blind Controlled, Parallel-group Designed Trial. | 2016 | J Oleo Sci | pmid:27321122 |
| Shinohara N et al. | jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. | 2012 | J Oleo Sci | pmid:22864514 |