alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Schuchardt JP et al. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23694766
Ferretti A and Flanagan VP Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888358
Bellini MJ et al. Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:14580370
Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Burdge GC Metabolism of alpha-linolenic acid in humans. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16828546
Galli C and Marangoni F N-3 fatty acids in the Mediterranean diet. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16837180
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
de Groot RH et al. Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive functioning. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643178
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Decsi T et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401433
Kris-Etherton PM et al. Dietary reference intakes for DHA and EPA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19525100
Sanders TA DHA status of vegetarians. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500961
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Blanchard H et al. Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23579035
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Papies B et al. Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1679554
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Chavali SR et al. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610840
Burdge GC and Wootton SA Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907139
Joshi K et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16314082
Oliva ME et al. Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24120122
Hanke D et al. A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24140006
Vancassel S et al. Plasma fatty acid levels in autistic children. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487301
Kurowska EM et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591004
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Hurst S et al. Dietary fatty acids and arthritis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20189789
Arun Kumar C and Das UN Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574650
Zhou D et al. Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15519497
Tocher DR and Dick JR Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161581
Alava MA et al. Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10359023
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Harland DR et al. Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22858445
Muñoz SF et al. Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480075
Hrelia S et al. Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11334548
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Schimke I et al. Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9431820
Kim HW et al. Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880477
Hofacer R et al. Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047910
Glew RH et al. Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728165
Taha AY et al. Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26869088
Brenna JT et al. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19269799
Lorenzini A et al. Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9250697
Brouwer IA Omega-3 PUFA: good or bad for prostate cancer? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951003
Sravan Kumar G and Das UN Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150374
Attar-Bashi NM et al. Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17275274
Rapoport SI et al. Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. 2011 Prostaglandins Other Lipid Mediat. pmid:21704722
Conklin SM et al. Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. 2007 Psychiatry Res pmid:17383013
Rabinovitz S et al. Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). 2004 Psychoneuroendocrinology pmid:14604595
Levant B et al. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. 2008 Psychoneuroendocrinology pmid:18707812
Venna VR et al. PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. 2009 Psychoneuroendocrinology pmid:18848400
Segovia-Siapco G et al. Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. 2007 Public Health Nutr pmid:17261227
Petrogianni M et al. Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. 2014 Public Health Nutr pmid:23249766
van der Walt AM et al. Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo). 2009 Public Health Nutr pmid:18503724
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
McDonald GB and Weidman M Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. 1987 Q J Exp Physiol pmid:2884690
Marotta F et al. Liver exposure to xenobiotics: the aging factor and potentials for functional foods. 2006 Rejuvenation Res pmid:16706665
Guesnet P et al. Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. 1986 Reprod Nutr Dev pmid:2877477
Guesnet P et al. Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. 1988 Reprod Nutr Dev pmid:2897705
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Marei WF et al. Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. 2012 Reprod. Fertil. Dev. pmid:22697118
Acar N et al. The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid. 2006 Sep-Oct Reprod. Nutr. Dev. pmid:17107641
Bretillon L et al. In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat. 2006 Mar-Apr Reprod. Nutr. Dev. pmid:16597424
Burdge GC and Calder PC Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188209
De Lorgeril M and Salen P Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease. 2004 May-Jun Reprod. Nutr. Dev. pmid:15460167
Morise A et al. Dose effect of alpha-linolenic acid on lipid metabolism in the hamster. 2005 Jul-Aug Reprod. Nutr. Dev. pmid:16045889
Ponter AA et al. Effect of a supplement rich in linolenic acid added to the diet of post partum dairy cows on ovarian follicle growth, and milk and plasma fatty acid compositions. 2006 Jan-Feb Reprod. Nutr. Dev. pmid:16438912
Rao SS et al. Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. 2007 Nov-Dec Reprod. Toxicol. pmid:17825521
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Robinson RS et al. Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. 2002 Reproduction pmid:12090925
Smith GM and Isopenko A Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. 1997 Jan-Feb Res. Vet. Sci. pmid:9160431
Glocker TM [Pathology of placenta of rats induced by fatty acid deficiency]. 2000 Rev Fac Cien Med Univ Nac Cordoba pmid:12934235
MandaÅŸescu S et al. Flaxseed supplementation in hyperlipidemic patients. 2005 Jul-Sep Rev Med Chir Soc Med Nat Iasi pmid:16607740
Ulbricht C et al. Chia (Salvia hispanica): a systematic review by the natural standard research collaboration. 2009 Rev Recent Clin Trials pmid:20028328
Nordström DC et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. 1995 Rheumatol. Int. pmid:7597378
Sato M et al. [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. 1986 Rinsho Shinkeigaku pmid:2879661
Dybkowska E et al. [The comparison of fat, trans isomers and cholesterol intake in the diet of Warsaw inhabitants in relation to Polish food ration]. 2004 Rocz Panstw Zakl Hig pmid:19097583
McNamara RK et al. Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. 2009 Schizophr. Res. pmid:18993032
Fu X et al. Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. 2015 Sci Rep pmid:26567525
Wu MH et al. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. 2014 Sci Rep pmid:24651079
Liu X et al. APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates. 2015 Sci Rep pmid:26643045
Liechti R and Farmer EE Jasmonate biochemical pathway. 2006 Sci. STKE pmid:16478937
KORN ED and GREENBLATT CL SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. 1963 Science pmid:14074842
Bellaloui N and Mengistu A Effects of boron nutrition and water stress on nitrogen fixation, seed δ15N and δ13C dynamics, and seed composition in soybean cultivars differing in maturities. 2015 ScientificWorldJournal pmid:25667936
Wang Q et al. [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. 2006 Se Pu pmid:16827313
Cui K et al. [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. 1997 Se Pu pmid:15739324
Uauy R and Hoffman DR Essential fatty acid requirements for normal eye and brain development. 1991 Semin. Perinatol. pmid:1687090
Fan WX [Alpha-linolenic acid and its metabolites EPA and DHA]. 1988 Sheng Li Ke Xue Jin Zhan pmid:2901141
Zhang HT et al. [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. 2006 Sheng Wu Gong Cheng Xue Bao pmid:16572837
Liu L et al. [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. 2001 Sheng Wu Gong Cheng Xue Bao pmid:11411223
Larsson-Backström C et al. Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. 1995 Shock pmid:7552772
Trommer H et al. Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. 2003 Sep-Oct Skin Pharmacol. Appl. Skin Physiol. pmid:12907834
Chambron E [Dietetics in coronary patients]. 2005 Soins pmid:15999643
Hisha H et al. Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-taiho-to): stimulatory effects of its fatty acids on hemopoiesis in patients. 2002 Stem Cells pmid:12110700
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
Schreck U et al. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? 2002 Strahlenther Onkol pmid:12122788
Hejazi L et al. Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. 2011 Talanta pmid:21215858