alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Wang C et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. 2006 Am. J. Clin. Nutr. pmid:16825676
Renaud SC and Lanzmann-Petithory D The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. 2002 Am. J. Clin. Nutr. pmid:12324307
Bjerve KS et al. alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. 1989 Am. J. Clin. Nutr. pmid:2563625
Jeppesen PB et al. Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. 1999 Am. J. Clin. Nutr. pmid:10393142
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
de Groot RH et al. Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. 2004 Am. J. Clin. Nutr. pmid:14749231
Hu FB et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. 1999 Am. J. Clin. Nutr. pmid:10232627
Lin YH et al. Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. 2010 Am. J. Clin. Nutr. pmid:20534748
Bozian RC and Moussavian SN Human linolenic acid deficiency. 1982 Am. J. Clin. Nutr. pmid:6293298
Sanders TA Polyunsaturated fatty acids in the food chain in Europe. 2000 Am. J. Clin. Nutr. pmid:10617968
Uauy R and Hoffman DR Essential fat requirements of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617979
Baylin A et al. Adipose tissue biomarkers of fatty acid intake. 2002 Am. J. Clin. Nutr. pmid:12324287
Wilk JB et al. Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. 2012 Am. J. Clin. Nutr. pmid:22952185
Welch AA et al. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. 2010 Am. J. Clin. Nutr. pmid:20861171
Kwon JS et al. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. 1991 Am. J. Clin. Nutr. pmid:1677525
Baylin A et al. alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. 2007 Am. J. Clin. Nutr. pmid:17284757
Kardinaal AF et al. Relations between antioxidant vitamins in adipose tissue, plasma, and diet. 1995 Am. J. Epidemiol. pmid:7879788
Ingram AJ et al. Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. 1995 Am. J. Kidney Dis. pmid:7847360
Ascherio A Epidemiologic studies on dietary fats and coronary heart disease. 2002 Am. J. Med. pmid:12566133
De Lorgeril M and Salen P Fish and N-3 fatty acids for the prevention and treatment of coronary heart disease: nutrition is not pharmacology. 2002 Am. J. Med. pmid:11893373
JORDAN GL et al. The effect of linoleic and linolenic acid, estradiol valerate and beta sitosterol upon experimentally induced hypercholesterolemia and the development of lipid changes in the aorta of dogs. 1961 Am. J. Med. Sci. pmid:13790676
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
WARAVDEKAR VS et al. HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. 1964 Am. J. Pathol. pmid:14234476
Fiaccavento R et al. Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters. 2006 Am. J. Pathol. pmid:17148657
Hasler CM et al. Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. 1991 Am. J. Physiol. pmid:1677533
Emmison N et al. Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. 1995 Am. J. Physiol. pmid:7631907
Oe H et al. Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. 1994 Am. J. Physiol. pmid:7943384
Chen ZY et al. Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. 1995 Am. J. Physiol. pmid:7864247
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
López-Luna P et al. Fate of orally administered radioactive fatty acids in the late-pregnant rat. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26714850
Bessesen DH et al. Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10827016
Matravadia S et al. Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats. 2014 Am. J. Physiol. Endocrinol. Metab. pmid:24844257
Gong Z et al. G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. 2014 Am. J. Physiol. Endocrinol. Metab. pmid:24222669
Running CA and Mattes RD Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25540234
Friesen R and Innis SM Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16282365
McHowat J and Creer MH Selective plasmalogen substrate utilization by thrombin-stimulated Ca(2+)-independent PLA(2) in cardiomyocytes. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10843891
Bassett CM et al. The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. 2011 Am. J. Physiol. Heart Circ. Physiol. pmid:21963840
Ayalew-Pervanchon A et al. Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17526653
Matravadia S et al. LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. 2016 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26764053
Namiranian K et al. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20357027
Muller-Delp JM The role of TREK-1 in cerebrovascular regulation remains elusive: focus on "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20484697
Conde-Sieira M et al. Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. 2015 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26468264
Al-Khalifa A et al. Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17122327
Sea MM et al. Weight cycling-induced alteration in fatty acid metabolism. 2000 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:10956277
Turk HF et al. Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. 2013 Am. J. Physiol., Cell Physiol. pmid:23426968
Reiner WB et al. Fatty acids in mountain gorilla diets: implications for primate nutrition and health. 2014 Am. J. Primatol. pmid:24243235
Henry MM et al. Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. 1991 Am. J. Vet. Res. pmid:1675842
Morris DD et al. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. 1991 Am. J. Vet. Res. pmid:1675843
Munsterman AS et al. Effects of the omega-3 fatty acid, alpha-linolenic acid, on lipopolysaccharide-challenged synovial explants from horses. 2005 Am. J. Vet. Res. pmid:16261822
Mazaki-Tovi M et al. Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. 2011 Am. J. Vet. Res. pmid:21879986
Guelzim N et al. A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. 2011 Amino Acids pmid:21063737
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Wang YL et al. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. 2005 Anal Bioanal Chem pmid:16132135
Molkentin J and Giesemann A Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. 2007 Anal Bioanal Chem pmid:17393158
Martin CA et al. Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. 2006 Anal Sci pmid:16760612
Degousée N et al. Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. 1995 Anal. Biochem. pmid:7733454
Schneider C et al. Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. 2000 Anal. Biochem. pmid:11078601
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Hejazi L et al. Determination of the composition of fatty acid mixtures using GC x FI-MS: a comprehensive two-dimensional separation approach. 2009 Anal. Chem. pmid:19146461
Yoo HJ and HÃ¥kansson K Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. 2010 Anal. Chem. pmid:20704384
Gómez-Cortés P et al. Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. 2012 Anal. Chem. pmid:22662968
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Huang YQ et al. Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. 2011 Analyst pmid:21331428
HILDITCH TP and SHRIVASTAVA RK The spectrophotometric determination of small proportions of linolenic acid in fats. 1947 Analyst pmid:18901122
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Heller AR et al. Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. 2006 Anesth. Analg. pmid:16551943
Paschos GK et al. Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. 2005 Jan-Feb Angiology pmid:15678256
Kaka A et al. α-Linolenic acid supplementation in BioXcell® extender can improve the quality of post-cooling and frozen-thawed bovine sperm. 2015 Anim. Reprod. Sci. pmid:25544152
Mattioli S et al. Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones. 2017 Animal pmid:27819218
Yang YX et al. Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. 2013 Animal pmid:23031206
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Chen W et al. Effect of flaxseed on the fatty acid profile of egg yolk and antioxidant status of their neonatal offspring in Huoyan geese. 2015 Animal pmid:26173627
Budowski P et al. [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. 1980 Ann Nutr Aliment pmid:6254420
François M et al. [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. 1980 Ann Nutr Aliment pmid:6254422
Shi X et al. Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. 1997 Sep-Oct Ann. Clin. Lab. Sci. pmid:9303176
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Babu US et al. Impact of in vitro fatty acid uptake on nitric oxide production and antilisterial activity of WEHI-3 cells. 1996 Ann. N. Y. Acad. Sci. pmid:8993386
Kim JY et al. Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723055
Yu JH et al. Effects of omega-3 fatty acids on apoptosis of human gastric epithelial cells exposed to silica-immobilized glucose oxidase. 2009 Ann. N. Y. Acad. Sci. pmid:19723076
Park KS et al. Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. 2009 Ann. N. Y. Acad. Sci. pmid:19723085
Egert S et al. Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. 2008 Ann. Nutr. Metab. pmid:19011281
Ikeda A and Sugano M Interaction of dietary protein and alpha-linolenic acid on polyunsaturated fatty acid composition of liver microsomal phospholipids and eicosanoid production in streptozotocin-induced diabetic rats. 1993 Ann. Nutr. Metab. pmid:8103979
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Saito M Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. 1994 Ann. Nutr. Metab. pmid:7702359
Seppänen-Laakso T et al. Replacement of margarine on bread by rapeseed and olive oils: effects on plasma fatty acid composition and serum cholesterol. 1993 Ann. Nutr. Metab. pmid:8105749
Fuhrmann H and Sallmann HP Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. 1995 Ann. Nutr. Metab. pmid:8585700
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Becker W et al. Uptake of radiolabelled alpha-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid-deficient rats--an autoradiographic study. 1985 Ann. Nutr. Metab. pmid:2859826
Andersen G et al. Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. 2008 Ann. Nutr. Metab. pmid:18562792
Wenger FA et al. Does dietary alpha-linolenic acid promote liver metastases in pancreatic carcinoma initiated by BOP in Syrian hamster? 1999 Ann. Nutr. Metab. pmid:10436311
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Crawford M et al. Role of plant-derived omega-3 fatty acids in human nutrition. 2000 Ann. Nutr. Metab. pmid:11146334
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Barre DE Potential of evening primrose, borage, black currant, and fungal oils in human health. 2001 Ann. Nutr. Metab. pmid:11359029
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Ayerza R and Coates W Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. 2007 Ann. Nutr. Metab. pmid:17356263
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461