alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Dabadie H et al. Variations in daily intakes of myristic and alpha-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity. 2006 Br. J. Nutr. pmid:16923222
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Fretts AM et al. Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study. 2014 Br. J. Nutr. pmid:25159901
Haggarty P et al. The effect of maternal smoking and ethanol on fatty acid transport by the human placenta. 2002 Br. J. Nutr. pmid:12064333
Oikarinen SI et al. Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice. 2005 Br. J. Nutr. pmid:16197574
Xiao Y et al. Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain. 2005 Br. J. Nutr. pmid:16197579
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Chicco AG et al. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. 2009 Br. J. Nutr. pmid:18492301
Saito M and Kubo K Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. 2003 Br. J. Nutr. pmid:12568661
Leece EA and Allman MA The relationships between dietary alpha-linolenic:linoleic acid and rat platelet eicosapentaenoic and arachidonic acids. 1996 Br. J. Nutr. pmid:8881716
Turpeinen AM et al. Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. 2006 Br. J. Nutr. pmid:16571152
Tyagi A et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. 2012 Br. J. Nutr. pmid:22243775
Sabaté J et al. Does regular walnut consumption lead to weight gain? 2005 Br. J. Nutr. pmid:16277792
Burdge GC et al. Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. 2003 Br. J. Nutr. pmid:12908891
Vedtofte MS et al. Association between the intake of α-linolenic acid and the risk of CHD. 2014 Br. J. Nutr. pmid:24964401
Koga T et al. Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. 1997 Br. J. Nutr. pmid:9155511
Langdon JH Has an aquatic diet been necessary for hominin brain evolution and functional development? 2006 Br. J. Nutr. pmid:16869985
Maillard V et al. Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content. 2006 Br. J. Nutr. pmid:16869986
Barros R et al. Dietary intake of α-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. 2011 Br. J. Nutr. pmid:21443816
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Wensing AG et al. Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. 1999 Br. J. Nutr. pmid:10655965
de Deckere EA et al. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. 1999 Br. J. Nutr. pmid:10655980
Diwakar BT et al. Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. 2011 Br. J. Nutr. pmid:21521541
Oki E et al. Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. 2017 Br. J. Nutr. pmid:28633686
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Couëdelo L et al. Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. 2011 Br. J. Nutr. pmid:21080982
Seppänen-Laakso T et al. Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. 1992 Br. J. Nutr. pmid:1362891
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Vermunt SH et al. Dietary trans alpha-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TransLinE Study. 2001 Br. J. Nutr. pmid:11299084
Gerber M Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. 2012 Br. J. Nutr. pmid:22591896
Vyncke KE et al. Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. 2012 Br. J. Nutr. pmid:22370331
Sanjurjo P et al. Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. 2006 Br. J. Nutr. pmid:16441930
Griffin BA Goldilocks and the three bonds: new evidence for the conditional benefits of dietary α-linolenic acid in treating cardiovascular risk in the metabolic syndrome. 2012 Br. J. Nutr. pmid:22894910
Baxheinrich A et al. Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. 2012 Br. J. Nutr. pmid:22894911
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Botsoglou E et al. Effect of supplementation of the laying hen diet with olive leaves (Olea europea L.) on lipid oxidation and fatty acid profile of α-linolenic acid enriched eggs during storage. 2012 Br. Poult. Sci. pmid:23130586
Parmentier HK et al. Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. 2002 Br. Poult. Sci. pmid:12365510
Dänicke S et al. Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. 1997 Br. Poult. Sci. pmid:9511000
Antruejo A et al. Omega-3 enriched egg production: the effect of α -linolenic ω -3 fatty acid sources on laying hen performance and yolk lipid content and fatty acid composition. 2011 Br. Poult. Sci. pmid:22221241
Gonzalez-Esquerra R and Leeson S Effects of menhaden oil and flaxseed in broiler diets on sensory quality and lipid composition of poultry meat. 2000 Br. Poult. Sci. pmid:11128390
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Nishizaki T et al. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. 1997 Brain Res. pmid:9099812
Rao GN et al. Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. 2000 Breast Cancer Res. Treat. pmid:11200779
Thiébaut AC et al. [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. 2005 Bull Cancer pmid:16123005
Astorg P [Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]. 2005 Bull Cancer pmid:16123006
Bougnoux P and Menanteau J [Dietary fatty acids and experimental carcinogenesis]. 2005 Bull Cancer pmid:16123007
Ohta S et al. Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. 1994 Bull Environ Contam Toxicol pmid:7910498
Crastes de Paulet A et al. [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. 1994 Bull. Acad. Natl. Med. pmid:7913655
Bourre JM [Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function]. 1989 Bull. Acad. Natl. Med. pmid:2576722
Piconneaux A et al. [Identification of an atypical polyunsaturated fatty acid present in the liver of rats after the ingestion of heated linseed oil]. 1985 C. R. Acad. Sci. III, Sci. Vie pmid:2859918
Cherif A et al. Phytosterols, unsaturated fatty acid composition and accumulation in the almond kernel during harvesting period: importance for development regulation. 2009 C. R. Biol. pmid:19931844
Sebei K et al. Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). 2006 C. R. Biol. pmid:16945838
Fournier J et al. [Lipid peroxidation in the presence of inorganic compounds. Relation to oxidative stress mechanisms]. 1995 C. R. Seances Soc. Biol. Fil. pmid:8521091
Oulhaj H et al. [Utilization of linoleate and alpha-linolenate in peritubular cells and Sertoli cells in culture]. 1994 C. R. Seances Soc. Biol. Fil. pmid:7834508
Rodriguez-Leyva D et al. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. 2010 Can J Cardiol pmid:21076723
Das UN Antibiotic-like action of essential fatty acids. 1985 Can Med Assoc J pmid:2860965
Scorolli L et al. [Photodynamic therapy for age related macular degeneration with and without antioxidants]. 2002 Can. J. Ophthalmol. pmid:12518724
Levy R and Herzberg GR Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. 1999 Can. J. Physiol. Pharmacol. pmid:10588486
Cunnane SC et al. Low zinc intake increases apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1993 Mar-Apr Can. J. Physiol. Pharmacol. pmid:8104673
Tranchant T et al. Long-term supplementation of culture medium with essential fatty acids alters alpha-linolenic acid uptake in Caco-2 clone TC7. 1998 Can. J. Physiol. Pharmacol. pmid:9923400
Monteiro J et al. Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. 2013 Can. J. Physiol. Pharmacol. pmid:23746194
Cunnane SC The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? 1996 Can. J. Physiol. Pharmacol. pmid:8909772
Cunnane SC and Likhodii SS 13C NMR spectroscopy and gas chromatograph--combustion--isotope ratio mass spectrometry: complementary applications in monitoring the metabolism of 13C-labelled polyunsaturated fatty acids. 1996 Can. J. Physiol. Pharmacol. pmid:8909789
Narisawa T et al. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. 1994 Cancer pmid:7908858
Koralek DO et al. A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). 2006 Cancer Causes Control pmid:16783606
Astorg P Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. 2004 Cancer Causes Control pmid:15141138
Carayol M et al. Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. 2010 Cancer Causes Control pmid:19921446
Jackson MD et al. Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. 2012 Cancer Causes Control pmid:21984307
Colditz GA Changing dietary patterns and cancer prevention: alpha-linolenic acid health risks and benefits. 2000 Cancer Causes Control pmid:11065003
Oh K et al. Dietary marine n-3 fatty acids in relation to risk of distal colorectal adenoma in women. 2005 Cancer Epidemiol. Biomarkers Prev. pmid:15824153
De Stéfani E et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. 2000 Cancer Epidemiol. Biomarkers Prev. pmid:10750674
Berquin IM et al. Multi-targeted therapy of cancer by omega-3 fatty acids. 2008 Cancer Lett. pmid:18479809
Kumar GS and Das UN Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. 1995 Cancer Lett. pmid:7757958
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Futakuchi M et al. Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). 2002 Cancer Lett. pmid:11867197
Franke AA et al. Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. 1994 Cancer Lett. pmid:7910514
Agatha G et al. Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. 2001 Cancer Lett. pmid:11597788
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Lok E et al. The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice. 1995 Cancer Lett. pmid:7600535
Kokura S et al. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. 1997 Cancer Res. pmid:9187121
Sauer LA et al. Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. 2000 Cancer Res. pmid:11016660
Hirose M et al. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. 1990 Carcinogenesis pmid:2110511
Komaki C et al. Synergistic suppression of azoxymethane-induced foci of colonic aberrant crypts by the combination of beta-carotene and perilla oil in rats. 1996 Carcinogenesis pmid:8824511
Onogi N et al. Suppressing effect of perilla oil on azoxymethane-induced foci of colonic aberrant crypts in rats. 1996 Carcinogenesis pmid:8681445
Tou JC and Thompson LU Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures. 1999 Carcinogenesis pmid:10469631
Tsuzuki T et al. Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. 2004 Carcinogenesis pmid:14963014
Pan P et al. Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. 2015 Carcinogenesis pmid:26246425
Duda MK et al. omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. 2009 Cardiovasc. Res. pmid:19474179
Carotenuto F et al. A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. 2013 Cardiovasc. Res. pmid:24042018
Ander BP et al. Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. 2007 Cardiovasc. Res. pmid:17059813
Hemmings SJ et al. The effects of dietary flaxseed on the Fischer 344 rat: II. Liver gamma-glutamyltranspeptidase activity. 2004 Jul-Aug Cell Biochem. Funct. pmid:15248182
Novo C et al. Altered fatty acid membrane composition modifies lymphocyte localization in vivo. 1987 Cell. Immunol. pmid:2882861
Wróbel A Decrease in 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) EPR signal in peroxynitrite-treated erythrocyte membranes. 2001 Cell. Mol. Biol. Lett. pmid:11753439
Shibata E et al. Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. 2013 Cell. Physiol. Biochem. pmid:24107614
Carrillo C et al. Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. 2011 Cell. Physiol. Biochem. pmid:21471726
Vinggaard AM et al. Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. 1997 Cell. Signal. pmid:9113419
Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Blanco M et al. Ischemic preconditioning: a novel target for neuroprotective therapy. 2006 Cerebrovasc. Dis. pmid:16651813