alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Fujiyama-Fujiwara Y et al. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. 1995 J. Nutr. Sci. Vitaminol. pmid:7562115
Yamanaka N et al. Alpha-Linolenic Acid-Enriched Diacylglycerol Oil Suppresses the Postprandial Serum Triglyceride Level-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. 2016 J. Nutr. Sci. Vitaminol. pmid:28202845
Foster M et al. Inflammation markers predict zinc transporter gene expression in women with type 2 diabetes mellitus. 2013 J. Nutr. Biochem. pmid:23643522
Extier A et al. Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion. 2010 J. Nutr. Biochem. pmid:19157821
Poudyal H et al. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23026492
Gorinstein S et al. Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. 2003 J. Nutr. Biochem. pmid:12742543
Kim HK et al. Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. 2004 J. Nutr. Biochem. pmid:15302084
Horia E and Watkins BA Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. 2005 J. Nutr. Biochem. pmid:15741054
Adkins Y and Kelley DS Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. 2010 J. Nutr. Biochem. pmid:20382009
Zhu H et al. Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. 2010 J. Nutr. Biochem. pmid:19954955
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Zhang J et al. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. 2012 J. Nutr. Biochem. pmid:21658928
Poudyal H et al. Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. 2012 J. Nutr. Biochem. pmid:21429727
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Zhao J et al. Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. 2011 J. Nutr. Biochem. pmid:21129946
Du Q et al. Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. 2012 J. Nutr. Biochem. pmid:22445803
Gladine C et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. 2013 J. Nutr. Biochem. pmid:22784432
FISHER H and LEVEILLE GA Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. 1957 J. Nutr. pmid:13476240
Harper CR et al. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. 2006 J. Nutr. pmid:17056811
Loï C et al. Incorporation and metabolism of dietary trans isomers of linolenic acid alter the fatty acid profile of rat tissues. 2000 J. Nutr. pmid:11015488
Winters BL et al. Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. 1994 J. Nutr. pmid:7916377
Simopoulos AP Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. 1989 J. Nutr. pmid:2564887
Murase T et al. Dietary alpha-linolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice. 2002 J. Nutr. pmid:12368389
Acar N et al. Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. 2002 J. Nutr. pmid:12368410
Bauer JE et al. Docosahexaenoic acid accumulates in plasma of canine puppies raised on alpha-linolenic acid-rich milk during suckling but not when fed alpha-linolenic acid-rich diets after weaning. 2006 J. Nutr. pmid:16772507
Bourre JM et al. Dietary alpha-linolenic acid at 1.3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. 1993 J. Nutr. pmid:8100576
Bourre JM et al. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. 1989 J. Nutr. pmid:2576038
Gregory MK et al. Functional characterization of the chicken fatty acid elongases. 2013 J. Nutr. pmid:23173174
Weiler HA and Fitzpatrick-Wong SC Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. 2002 J. Nutr. pmid:12221227
Chapkin RS and Carmichael SL Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. 1990 J. Nutr. pmid:1974284
Bourre JM et al. Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. 1989 J. Nutr. pmid:2563284
Barden AE et al. Flaxseed oil supplementation increases plasma F1-phytoprostanes in healthy men. 2009 J. Nutr. pmid:19675101
Clouard C et al. Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. 2015 J. Nutr. pmid:25644359
Fritsche KL and Johnston PV Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. 1990 J. Nutr. pmid:1979807
Bauer JE et al. Maternal diet alpha-linolenic acid during gestation and lactation does not increase docosahexaenoic acid in canine milk. 2004 J. Nutr. pmid:15284396
Belzung C et al. Alpha-linolenic acid deficiency modifies distractibility but not anxiety and locomotion in rats during aging. 1998 J. Nutr. pmid:9732316
Thijssen MA et al. Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. 2005 J. Nutr. pmid:16317124
Reinders I et al. Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adults. 2015 J. Nutr. pmid:25355842
Jia Q et al. Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. 2004 J. Nutr. pmid:15173396
Marklund M et al. A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. 2014 J. Nutr. pmid:25080537
Yang X and Dick TA Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). 1994 J. Nutr. pmid:7913126
Joffe YT et al. Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women. 2010 J. Nutr. pmid:20335630
Hellstrand S et al. Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. 2014 J. Nutr. pmid:25008580
Ander BP et al. Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. 2004 J. Nutr. pmid:15570021
de Lorgeril M and Salen P alpha-linolenic acid, coronary heart disease, and prostate cancer. 2004 J. Nutr. pmid:15570041
Iritani N et al. Lipogenic enzyme gene expression is quickly suppressed in rats by a small amount of exogenous polyunsaturated fatty acids. 1998 J. Nutr. pmid:9614155
Watanabe S et al. A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. 1994 J. Nutr. pmid:7916376
Harper CR et al. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. 2006 J. Nutr. pmid:16365063
Eder K et al. Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and alpha-linolenic acids in HepG2 cells. 2002 J. Nutr. pmid:12042419
Kimura Y Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. 2002 J. Nutr. pmid:12097695
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Brouwer IA et al. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. 2004 J. Nutr. pmid:15051847
Hwang DH et al. Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. 1988 J. Nutr. pmid:2895804
Ikeda I et al. alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. 1994 J. Nutr. pmid:7931698
Dunbar BL and Bauer JE Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. 2002 J. Nutr. pmid:12042499
Hassan A et al. An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis. 2010 J. Nutr. pmid:20724486
MOHRHAUER H and HOLMAN RT EFFECT OF LINOLENIC ACID UPON THE METABOLISM OF LINOLEIC ACID. 1963 J. Nutr. pmid:14061405
Dewell A et al. Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. 2011 J. Nutr. pmid:22031659
Letona AZ et al. CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. 2011 J. Nutr. pmid:21628634
Zhao G et al. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. 2004 J. Nutr. pmid:15514264
Deckelbaum RJ and Torrejon C The omega-3 fatty acid nutritional landscape: health benefits and sources. 2012 J. Nutr. pmid:22323763
Veltri BC et al. Adipose fatty acid composition and rate of incorporation of alpha-linolenic acid differ between normal and lipoprotein lipase-deficient cats. 2006 J. Nutr. pmid:17116707
Arthur JR Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. 1988 J. Nutr. pmid:2897437
Farina EK et al. Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. 2011 J. Nutr. pmid:21508210
Umezawa M et al. High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. 1999 J. Nutr. pmid:10024623
Goyens PL and Mensink RP The dietary alpha-linolenic acid to linoleic acid ratio does not affect the serum lipoprotein profile in humans. 2005 J. Nutr. pmid:16317123
Caligiuri SP et al. Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. 2013 J. Nutr. pmid:23902961
Gong J et al. Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. 2011 J. Nutr. pmid:22049297
Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Couëdelo L et al. The fraction of α-linolenic acid present in the sn-2 position of structured triacylglycerols decreases in lymph chylomicrons and plasma triacylglycerols during the course of lipid absorption in rats. 2012 J. Nutr. pmid:22131546
Liou YA et al. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. 2007 J. Nutr. pmid:17374659
Cowey CB et al. Tissue distribution, uptake, and requirement for alpha-tocopherol of rainbow trout (Salmo gairdneri) fed diets with a minimal content of unsaturated fatty acids. 1981 J. Nutr. pmid:6268765
Fayard JM et al. Dietary alpha-linolenic acid deficiency and early uterine development in female rats. 1992 J. Nutr. pmid:1352346
CHENG AL et al. The effect of fat level of the diet on general nutrition. XV. Comparison of the protective effect of linoleic acid and linolenic acid against multiple sublethal doses of x-irradiation in the rat. 1955 J. Nutr. pmid:14368364
Thies F et al. Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. 2001 J. Nutr. pmid:11435508
Imhoff-Kunsch B et al. Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. 2011 J. Nutr. pmid:21178076
Ikemoto A et al. Lysosomal enzyme activities are decreased in the retina and their circadian rhythms are different from those in the pineal gland of rats fed an alpha-linolenic acid-restricted diet. 2000 J. Nutr. pmid:11110869
RAHM JJ and HOLMAN RT EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. 1964 J. Nutr. pmid:14210015
Luo T et al. Consumption of Walnuts in Combination with Other Whole Foods Produces Physiologic, Metabolic, and Gene Expression Changes in Obese C57BL/6J High-Fat-Fed Male Mice. 2016 J. Nutr. pmid:27489005
Delion S et al. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. 1994 J. Nutr. pmid:16856329
Tsuzuki T et al. Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. 2006 J. Nutr. pmid:16857834
Levant B et al. Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. 2006 J. Nutr. pmid:16857847
Dumont J et al. FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. 2011 J. Nutr. pmid:21593353
Carlson SE et al. High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. 1986 J. Nutr. pmid:2871142
Kabagambe EK et al. The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. 2005 J. Nutr. pmid:16251629
Petrik MB et al. Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. 2000 J. Nutr. pmid:11015469
Morson LA and Clandinin MT Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. 1986 J. Nutr. pmid:2879899
Sun Y et al. Plasma α-Linolenic and Long-Chain ω-3 Fatty Acids Are Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults. 2016 J. Nutr. pmid:26609174
Dodington DW et al. Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. 2015 J. Nutr. pmid:26423734
Liao K et al. Dietary Olive and Perilla Oils Affect Liver Mitochondrial DNA Methylation in Large Yellow Croakers. 2015 J. Nutr. pmid:26400965
Egert S et al. Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. 2009 J. Nutr. pmid:19261730
Miller MR et al. Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L.). 2008 J. Nutr. pmid:18936216
Takahashi R et al. Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. 1987 J. Nutr. pmid:2888839
Okuno M et al. Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. 1997 J. Nutr. pmid:9278555
Umezawa M et al. Serum lipid concentrations and mean life span are modulated by dietary polyunsaturated fatty acids in the senescence-accelerated mouse. 2000 J. Nutr. pmid:10720173
Tsuge H et al. Effects of vitamin B-6 on (n-3) polyunsaturated fatty acid metabolism. 2000 J. Nutr. pmid:10721899
Shang X et al. Dietary α-Linolenic Acid and Total ω-3 Fatty Acids Are Inversely Associated with Abdominal Aortic Calcification in Older Women, but Not in Older Men. 2015 J. Nutr. pmid:26041673
Lee YJ and Jenkins TC Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. 2011 J. Nutr. pmid:21653571