| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tachycardia, Ventricular | D017180 | 9 associated lipids |
| Long QT Syndrome | D008133 | 10 associated lipids |
| Retinal Degeneration | D012162 | 9 associated lipids |
| Malaria, Falciparum | D016778 | 22 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Irritable Bowel Syndrome | D043183 | 8 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Sebaceous Gland Neoplasms | D012626 | 2 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stivala S et al. | Dietary α-linolenic acid increases the platelet count in ApoE-/- mice by reducing clearance. | 2013 | Blood | pmid:23801636 |
| Pan X et al. | Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissimum L.) seed catalyzing the selective production of trilinolenin. | 2013 | J. Biol. Chem. | pmid:23824186 |
| Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
| Wang DQ et al. | [Alpha-linolenic acid improves insulin sensitivity in obese patients]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23648351 |
| Oh HJ et al. | Production of 10-hydroxy-12,15(Z,Z)-octadecadienoic acid from α-linolenic acid by permeabilized cells of recombinant Escherichia coli expressing the oleate hydratase gene of Stenotrophomonas maltophilia. | 2013 | Biotechnol. Lett. | pmid:23690042 |
| Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
| Sengupta A and Ghosh M | Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. | 2013 | Indian J. Exp. Biol. | pmid:23678545 |
| Rao CV et al. | Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. | 2013 | Nutr Cancer | pmid:23682783 |
| Hutchins AM et al. | Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. | 2013 | Nutr Res | pmid:23684438 |
| Simon MC et al. | Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes. | 2013 | Clin. Exp. Immunol. | pmid:23600826 |
| Foster M et al. | Inflammation markers predict zinc transporter gene expression in women with type 2 diabetes mellitus. | 2013 | J. Nutr. Biochem. | pmid:23643522 |
| Mapiye C et al. | Effects of feeding flaxseed or sunflower-seed in high-forage diets on beef production, quality and fatty acid composition. | 2013 | Meat Sci. | pmid:23669875 |
| Emery JA et al. | Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. | 2013 | PLoS ONE | pmid:23460861 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
| Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
| Gregory MK et al. | Functional characterization of the chicken fatty acid elongases. | 2013 | J. Nutr. | pmid:23173174 |
| Tu WC et al. | Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23085323 |
| Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
| Poudyal H et al. | Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23026492 |
| Yang YX et al. | Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. | 2013 | Animal | pmid:23031206 |
| Blanchard H et al. | Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23579035 |
| Hawkins A et al. | Effects of urea formaldehyde condensation polymer treatment of flaxseed on ruminal digestion and lactation in dairy cows. | 2013 | J. Dairy Sci. | pmid:23548281 |
| Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
| MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
| Ma T et al. | Effect of droplet size on autoxidation rates of methyl linoleate and α-linolenate in an oil-in-water emulsion. | 2013 | J Oleo Sci | pmid:24292352 |
| Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
| Sonne DP and Knop FK | Cardiovascular effects of alpha-linolenic acid--a possible role of glucagon-like peptide-1. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24174423 |
| Hoque M et al. | Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. | 2013 | PLoS ONE | pmid:24039698 |
| Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
| Arya E et al. | Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats. | 2013 | Biomed Res Int | pmid:24027769 |
| Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
| Zhang W et al. | Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. | 2013 | PLoS ONE | pmid:23861910 |
| Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
| Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
| Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
| Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
| Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
| Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
| Rodriguez-Leyva D et al. | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | 2013 | Hypertension | pmid:24126178 |
| Hoffmann I and Oliw EH | Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum. | 2013 | J. Lipid Res. | pmid:24082064 |
| Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
| Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
| Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
| Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
| Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
| de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |