alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
de Lorgeril M et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. 1994 Lancet pmid:7911176
Yehuda S et al. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. 1994 Eur. J. Pharmacol. pmid:7911428
Chen Q and Nilsson A Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. 1994 J. Lipid Res. pmid:7911819
Caffieri S et al. Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. 1994 J. Photochem. Photobiol. B, Biol. pmid:7912265
Lapenna D et al. Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. 1994 Free Radic. Res. pmid:7912612
Crastes de Paulet A et al. [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. 1994 Bull. Acad. Natl. Med. pmid:7913655
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Mantzioris E et al. Mediterranean diet. 1994 Lancet pmid:7914327
Yamaguchi Y et al. Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. 1994 Magnes Res pmid:7914418
Bougnoux P et al. alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. 1994 Br. J. Cancer pmid:7914425
Cunnane SC and McIntosh D alpha-Linolenic acid and reduction of cardiac deaths. 1994 Lancet pmid:7914995
Marckmann P and Jespersen J alpha-Linolenic acid and reduction of cardiac deaths. 1994 Lancet pmid:7914996
Winters BL et al. Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. 1994 J. Nutr. pmid:7916377
Rice RD Mediterranean diet. 1994 Lancet pmid:7916429
Ackman RG alpha-Linolenic acid in human adipose tissue. 1994 Lipids pmid:7916440
Mlakar A and Spiteller G Reinvestigation of lipid peroxidation of linolenic acid. 1994 Biochim. Biophys. Acta pmid:7918602
Yuasa H et al. Evaluation of milk fat-globule membrane (MFGM) emulsion for oral administration: absorption of alpha-linolenic acid in rats and the effect of emulsion droplet size. 1994 Biol. Pharm. Bull. pmid:7920450
Kawashima Y et al. Modulation by dietary oils and clofibric acid of arachidonic acid content in phosphatidylcholine in liver and kidney of rat: effects on prostaglandin formation in kidney. 1994 Biochim. Biophys. Acta pmid:8280769
Lawrence JF et al. An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. 1994 Nat. Toxins pmid:7866668
Mantzioris E et al. Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. 1994 Am. J. Clin. Nutr. pmid:7910999
Anderson GJ and Connor WE Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. 1994 Am. J. Clin. Nutr. pmid:7911000
Uauy-Dagach R et al. Essential fatty acid metabolism and requirements for LBW infants. 1994 Acta Paediatr Suppl pmid:7734797
Richieri GV et al. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. 1994 J. Biol. Chem. pmid:7929039
Yang X and Dick TA Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). 1994 J. Nutr. pmid:7913126
Yang J et al. Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1994 Metab. Clin. Exp. pmid:7914345
Regdel D et al. On the reaction specificity of the lipoxygenase from tomato fruits. 1994 Biochim. Biophys. Acta pmid:7905748
Lockwood K et al. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. 1994 Biochem. Biophys. Res. Commun. pmid:7908519
Uauy R et al. Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. 1994 J. Pediatr. pmid:7908693
Mourente G and Tocher DR In vivo metabolism of [1-14C]linolenic acid (18:3(n-3)) and [1-14C]eicosapentaenoic acid (20:5(n-3)) in a marine fish: time-course of the desaturation/elongation pathway. 1994 Biochim. Biophys. Acta pmid:7908832
Narisawa T et al. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. 1994 Cancer pmid:7908858
Mibu H et al. A study on lipid peroxide-induced lens damage in vitro. 1994 Exp. Eye Res. pmid:7908884
Laethem RM et al. Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. 1994 Biochim. Biophys. Acta pmid:7910485
Grandgirard A et al. Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. 1994 Lipids pmid:7909911
Ohta S et al. Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. 1994 Bull Environ Contam Toxicol pmid:7910498
Franke AA et al. Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. 1994 Cancer Lett. pmid:7910514
Yang JG et al. Determination of the contents of EPA and DHA and lipid constituents in main fresh water fishes in China. 1994 J. Tongji Med. Univ. pmid:7966518
Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Goré J et al. Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. 1994 Lipids pmid:7861937
Zakhariv OIa and Ianovych VH [Use of [1-14C]linolenic acid in lipid synthesis in ruminant tissues during the prenatal and postnatal periods of development in vitro]. 1993 Sep-Oct Ukr. Biokhim. Zh. pmid:7909179
Jiang Z and Sim JS Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. 1993 Nov-Dec Nutrition pmid:7906572
Cunnane SC et al. Low zinc intake increases apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1993 Mar-Apr Can. J. Physiol. Pharmacol. pmid:8104673
Spady DK Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. 1993 J. Lipid Res. pmid:8105015
Shichiri G et al. Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. 1993 Arch. Biochem. Biophys. pmid:8099780
Ikeda A and Sugano M Interaction of dietary protein and alpha-linolenic acid on polyunsaturated fatty acid composition of liver microsomal phospholipids and eicosanoid production in streptozotocin-induced diabetic rats. 1993 Ann. Nutr. Metab. pmid:8103979
Bourre JM et al. Function of dietary polyunsaturated fatty acids in the nervous system. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8093816
Hanai T et al. Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. 1993 J. Surg. Res. pmid:8094103
Ferrari-Iliou R et al. In vitro photodynamic lipid peroxidation of total lipophilic extracts from leaves of bean plants. 1993 Biochim. Biophys. Acta pmid:8094299
Cantrill RC et al. Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells. 1993 Lipids pmid:8096621
Cunnane SC et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. 1993 Br. J. Nutr. pmid:8098222
Bourre JM et al. Dietary alpha-linolenic acid at 1.3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. 1993 J. Nutr. pmid:8100576
Browse J et al. Mutants of Arabidopsis deficient in the synthesis of alpha-linolenate. Biochemical and genetic characterization of the endoplasmic reticulum linoleoyl desaturase. 1993 J. Biol. Chem. pmid:8102138
Dinh TK et al. Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats. 1993 Lipids pmid:8102769
Javouhey-Donzel A et al. Rat vitamin E status and heart lipid peroxidation: effect of dietary alpha-linolenic acid and marine n-3 fatty acids. 1993 Lipids pmid:8102771
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Giovannucci E et al. A prospective study of dietary fat and risk of prostate cancer. 1993 J. Natl. Cancer Inst. pmid:8105097
Seppänen-Laakso T et al. Replacement of margarine on bread by rapeseed and olive oils: effects on plasma fatty acid composition and serum cholesterol. 1993 Ann. Nutr. Metab. pmid:8105749
Kawashima Y and Kozuka H Dietary manipulation by perilla oil and fish oil of hepatic lipids and its influence on peroxisomal beta-oxidation and serum lipids in rat and mouse. 1993 Biol. Pharm. Bull. pmid:8130766
Wang N and Anderson RE Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. 1993 Biochemistry pmid:7903049
Cao J et al. Inhibition of fatty acid delta 6- and delta 5-desaturation by cyclopropene fatty acids in rat liver microsomes. 1993 Biochim. Biophys. Acta pmid:7903050
Nakashima Y et al. Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. 1993 J. Lipid Res. pmid:8094090
Bierenbaum ML et al. Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. 1993 J Am Coll Nutr pmid:7903324
Carter J Flax seed as a source of alpha linolenic acid. 1993 J Am Coll Nutr pmid:7903325
Tang AB et al. Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. 1993 Lipids pmid:7904040
Green P and Yavin E Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. 1993 J. Lipid Res. pmid:7905509
Saad Aida MA et al. Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part I. Serum unsaturated fatty acids. 1993 Nahrung pmid:7907168
Garg ML and Clandinin MT Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. 1992 May-Jun Nutrition pmid:1356032
Boudreau MD et al. Alpha-linolenic acid and prostaglandin synthesis. 1992 May-Jun Nutrition pmid:1356033
Emken EA et al. Human metabolic studies with deuterated alpha-linolenic acid. 1992 May-Jun Nutrition pmid:1356034
Kelley DS Alpha-linolenic acid and immune response. 1992 May-Jun Nutrition pmid:1356035
Dick TA and Yang X Alpha-linolenic acid metabolism in fish. 1992 May-Jun Nutrition pmid:1356036
Sim JS et al. Alpha-linolenic acid metabolism: the chicken and the egg. 1992 May-Jun Nutrition pmid:1356037
Bjerve KS et al. Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. 1992 Mar-Apr Nutrition pmid:1350473
Singer P Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. 1992 Mar-Apr Nutrition pmid:1350474
Holub BJ and Celi B Relationships of alpha-linolenic acid to platelet fatty acid composition and trans content of cholesterol-free foods. 1992 Mar-Apr Nutrition pmid:1350475
Gibson RA et al. Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. 1992 Biochim. Biophys. Acta pmid:1351403
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Noguchi A et al. Effects of casein and soy-protein on alpha-linolenic acid metabolism in rats. 1992 J. Nutr. Sci. Vitaminol. pmid:1363922
Cunnane S Cholesterol lowering by alpha-linolenic acid. 1992 Am. J. Clin. Nutr. pmid:1345883
Yamazaki K et al. Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. 1992 Biochim. Biophys. Acta pmid:1346092
Bourre JM et al. Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. 1992 Biochim. Biophys. Acta pmid:1347458
Arbuckle LD and Innis SM Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. 1992 Lipids pmid:1349717
Alsted AL and Høy CE Fatty acid profiles of brain phospholipid subclasses of rats fed n - 3 polyunsaturated fatty acids of marine or vegetable origin. A two generation study. 1992 Biochim. Biophys. Acta pmid:1350736
Arbuckle LD et al. Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). 1992 Biochim. Biophys. Acta pmid:1350737
Fayard JM et al. Dietary alpha-linolenic acid deficiency and early uterine development in female rats. 1992 J. Nutr. pmid:1352346
Simopoulos AP et al. Common purslane: a source of omega-3 fatty acids and antioxidants. 1992 J Am Coll Nutr pmid:1354675
Rabinovitch-Chable H et al. Purification of lipoxygenase and hydroperoxide dehydrase in flaxseeds: interaction between these enzymatic activities. 1992 Biochem. Biophys. Res. Commun. pmid:1359887
Hoffman DR and Uauy R Essentiality of dietary omega 3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. 1992 Lipids pmid:1362792
Seppänen-Laakso T et al. Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. 1992 Br. J. Nutr. pmid:1362891
Sakai K et al. Lipid lowering effects of high linoleate and high alpha-linolenate diets in rats and mice. Consequence of long-term feedings. 1992 Chem. Pharm. Bull. pmid:1358471
Cunnane SC et al. Alpha-linolenic acid in humans: direct functional role or dietary precursor? 1991 Nov-Dec Nutrition pmid:1686981
Cook HW Brain metabolism of alpha-linolenic acid during development. 1991 Nov-Dec Nutrition pmid:1686982
Wainwright PE Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development. 1991 Nov-Dec Nutrition pmid:1686983
Uauy R and Hoffman DR Essential fatty acid requirements for normal eye and brain development. 1991 Semin. Perinatol. pmid:1687090
Hasler CM et al. Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. 1991 Am. J. Physiol. pmid:1677533
Horii T et al. Effect of dietary alpha-linolenate on platelet-activating factor production in rat peritoneal polymorphonuclear leukocytes. 1991 J. Immunol. pmid:1679081
Papies B et al. Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1679554
Rhodes PG et al. Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1681044
Sakai K and Okuyama H Effects of a high alpha-linolenate and high linoleate diet on hemolysis and lipid peroxidation of rat erythrocytes. 1991 Chem. Pharm. Bull. pmid:1682062