alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with alpha-linolenic acid?

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What functions are associated with alpha-linolenic acid?


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What lipids are associated with alpha-linolenic acid?

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What genes are associated with alpha-linolenic acid?

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What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

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Authors Title Published Journal PubMed Link
Vinggaard AM et al. Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. 1997 Cell. Signal. pmid:9113419
Oh-hashi K et al. Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. 1997 Biol. Pharm. Bull. pmid:9084876
Sugihara N et al. Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid. 1997 Toxicology pmid:9160106
Kokura S et al. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. 1997 Cancer Res. pmid:9187121
Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Kudo N and Kawashima Y Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice. 1997 Toxicol. Appl. Pharmacol. pmid:9266801
Specht-Overholt S et al. Fatty acid composition of commercially manufactured omega-3 enriched pork products, haddock, and mackerel. 1997 J. Anim. Sci. pmid:9303450
Hardwick SJ et al. Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate. 1997 Free Radic. Res. pmid:9167940
Guesnet P et al. Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat. 1997 Lipids pmid:9168459
Spitzer V et al. Structure analysis of an allene-containing estolide tetraester triglyceride in the seed oil of Sebastiana commersoniana (Euphorbiaceae). 1997 Lipids pmid:9168462
Greiner RC et al. Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. 1997 Pediatr. Res. pmid:9396565
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Howlett NG and Avery SV Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. 1997 Appl. Environ. Microbiol. pmid:9251184
Harvei S et al. Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. 1997 Int. J. Cancer pmid:9178806
Cui K et al. [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. 1997 Se Pu pmid:15739324
Yehuda S et al. Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. 1997 Eur. J. Pharmacol. pmid:9203563
Hussey HJ and Tisdale MJ Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). 1997 Br. J. Cancer pmid:9062405
Nishizaki T et al. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. 1997 Brain Res. pmid:9099812
Das I et al. Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. 1997 Biochem. Soc. Trans. pmid:9056997
van Niel MH and Beynen AC The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. 1997 Vet Q pmid:9413110
Koga T et al. Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. 1997 Br. J. Nutr. pmid:9155511
Billeaud C et al. Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study. 1997 Eur J Clin Nutr pmid:11248877
Dänicke S et al. Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. 1997 Br. Poult. Sci. pmid:9511000
Hisha H et al. Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to. 1997 Blood pmid:9242532
Lanson M et al. Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. 1997 J Lipid Mediat Cell Signal pmid:9246607
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
Lorenzini A et al. Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9250697
Huang MZ et al. Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats. 1997 Lipids pmid:9252963
Jeffery NM et al. Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. 1997 Br. J. Nutr. pmid:9175999
Sugiyama K et al. Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. 1997 Lipids pmid:9270978
Tomioka H et al. Effector molecules of the host defence mechanism against Mycobacterium avium complex: the evidence showing that reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids each alone are not decisive in expression of macrophage antimicrobial activity against the parasites. 1997 Clin. Exp. Immunol. pmid:9276519
Okuno M et al. Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. 1997 J. Nutr. pmid:9278555
Freese R and Mutanen M Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9280178
Kelso KA et al. Effects of dietary supplementation with alpha-linolenic acid on the phospholipid fatty acid composition and quality of spermatozoa in cockerel from 24 to 72 weeks of age. 1997 J. Reprod. Fertil. pmid:9227357
Ratnayake WM et al. Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. 1997 J. Pediatr. Gastroenterol. Nutr. pmid:9327370
Harris WS n-3 fatty acids and serum lipoproteins: human studies. 1997 Am. J. Clin. Nutr. pmid:9129504
Sravan Kumar G and Das UN Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150374
Anthony FA et al. Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. 1997 Feb-Apr Photodermatol Photoimmunol Photomed pmid:9361122
Smith GM and Isopenko A Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. 1997 Jan-Feb Res. Vet. Sci. pmid:9160431
Gatchalian-Yee M et al. Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. 1997 Jul-Aug Nutrition pmid:9263255
Hall JA et al. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. 1997 Jul-Aug J. Vet. Intern. Med. pmid:9298479
Shi X et al. Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. 1997 Sep-Oct Ann. Clin. Lab. Sci. pmid:9303176
Yamada N et al. Changes in platelet aggregation and lipid metabolism in rats given dietary lipids containing different n-3 polyunsaturated fatty acids. 1998 J. Nutr. Sci. Vitaminol. pmid:9675708
Colquhoun A Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells. 1998 Biochem. Mol. Biol. Int. pmid:9678254
Schwab US et al. The effect of quality and amount of dietary fat on the susceptibility of low density lipoprotein to oxidation in subjects with impaired glucose tolerance. 1998 Eur J Clin Nutr pmid:9683400
Menard CR et al. Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. 1998 J. Neurochem. pmid:9798942
Giovannini M et al. The role of dietary polyunsaturated fatty acids during the first 2 years of life. 1998 Early Hum. Dev. pmid:10102658
Ikeda I et al. Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. 1998 Biosci. Biotechnol. Biochem. pmid:9614698
Prasad K et al. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. 1998 Atherosclerosis pmid:9543108
Edwards R et al. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. 1998 J Affect Disord pmid:9543204
Zimmer L et al. Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. 1998 Neurosci. Lett. pmid:9502233
Bretillon L et al. Oxidative metabolism of [1-14C] mono-trans isomers of linoleic and alpha-linolenic acids in the rat. 1998 Biochim. Biophys. Acta pmid:9507133
Pähkla R et al. Comparison of the antioxidant activity of melatonin and pinoline in vitro. 1998 J. Pineal Res. pmid:9510434
Sakamoto T et al. Alteration of low-temperature susceptibility of the cyanobacterium Synechococcus sp. PCC 7002 by genetic manipulation of membrane lipid unsaturation. 1998 Arch. Microbiol. pmid:9396831
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Freiberger CE et al. Nutrient content of the edible leaves of seven wild plants from Niger. 1998 Plant Foods Hum Nutr pmid:10890758
Hamberg M A pathway for biosynthesis of divinyl ether fatty acids in green leaves. 1998 Lipids pmid:9870900
Tranchant T et al. Long-term supplementation of culture medium with essential fatty acids alters alpha-linolenic acid uptake in Caco-2 clone TC7. 1998 Can. J. Physiol. Pharmacol. pmid:9923400
Belzung C et al. Alpha-linolenic acid deficiency modifies distractibility but not anxiety and locomotion in rats during aging. 1998 J. Nutr. pmid:9732316
Jayatilleke A and Shaw S Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. 1998 Alcohol pmid:9665313
Chavali SR et al. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610840
Iritani N et al. Lipogenic enzyme gene expression is quickly suppressed in rats by a small amount of exogenous polyunsaturated fatty acids. 1998 J. Nutr. pmid:9614155
De Stefani E et al. Essential fatty acids and breast cancer: a case-control study in Uruguay. 1998 Int. J. Cancer pmid:9590123
Peterson LD et al. Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. 1998 Life Sci. pmid:9627080
Okuno M et al. Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. 1998 Nutr Cancer pmid:9631489
Suzuki H et al. Long-term effect of a trace amount of tea catechins with perilla oil on the plasma lipids in mice. 1998 Int J Vitam Nutr Res pmid:9706503
Howe PR Omega 3 fatty acids--an Australian perspective. 1998 World Rev Nutr Diet pmid:9648518
Yu G et al. Fatty acid composition in colostrum and mature milk from non-atopic and atopic mothers during the first 6 months of lactation. 1998 Acta Paediatr. pmid:9722244
Gerster H Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? 1998 Int J Vitam Nutr Res pmid:9637947
Weisinger HS et al. Effect of diet on the rate of depletion of n-3 fatty acids in the retina of the guinea pig. 1998 J. Lipid Res. pmid:9643359
Vartak S et al. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. 1998 Br. J. Cancer pmid:9635836
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Dokko RC et al. Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. 1998 Int. J. Biochem. Cell Biol. pmid:9597754
Kemp B et al. Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. 1998 Theriogenology pmid:10732036
Pang D et al. Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. 1998 Br. J. Nutr. pmid:9828757
Parchmann S and Mueller MJ Evidence for the formation of dinor isoprostanes E1 from alpha-linolenic acid in plants. 1998 J. Biol. Chem. pmid:9830005
Ihara M et al. Comparative effects of short- and long-term feeding of safflower oil and perilla oil on lipid metabolism in rats. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9972297
Furuno K et al. Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. 1998 Pharmacol. Toxicol. pmid:9820879
Bretillon L et al. Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. 1998 J. Lipid Res. pmid:9799809
Ryu SB and Wang X Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. 1998 Biochim. Biophys. Acta pmid:9714802
Yehuda S et al. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. 1998 Neurochem. Res. pmid:9566600
Yehuda S et al. Fatty acids and brain peptides. 1998 Peptides pmid:9493877
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Gu JY et al. Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. 1998 Biosci. Biotechnol. Biochem. pmid:9836427
Rao MS et al. Yield, protein, and oil quality of soybean genotypes selected for tofu production. 1998 Plant Foods Hum Nutr pmid:9950085
Su HM et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. 1999 Pediatr. Res. pmid:9890614
Billman GE et al. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. 1999 Circulation pmid:10318669
Burke PA et al. Conditionally essential fatty acid deficiencies in end-stage liver disease. 1999 Nutrition pmid:10319364
Haggarty P et al. Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. 1999 Biol. Neonate pmid:10325438
Ihara-Watanabe M et al. Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. 1999 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:10327618
Muñoz SE et al. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. 1999 Nutrition pmid:10198915
Wenger FA et al. Does dietary alpha-linolenic acid promote liver metastases in pancreatic carcinoma initiated by BOP in Syrian hamster? 1999 Ann. Nutr. Metab. pmid:10436311
Becker CC et al. Effects of butter oil blends with increased concentrations of stearic, oleic and linolenic acid on blood lipids in young adults. 1999 Eur J Clin Nutr pmid:10452408
Khozin-Goldberg I et al. Salicylhydroxamic acid inhibits delta6 desaturation in the microalga Porphyridium cruentum. 1999 Biochim. Biophys. Acta pmid:10446425
Bowen RA et al. Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? 1999 Pediatr. Res. pmid:10367771
Hanley K et al. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. 1999 J. Invest. Dermatol. pmid:10571735
Baudouin E et al. Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. 1999 Plant J. pmid:10571894
Ezaki O et al. Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects. 1999 J. Nutr. Sci. Vitaminol. pmid:10737229
Chyb S et al. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. 1999 Nature pmid:9930700