Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Gutteridge JM | The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. | 1987 | Biochim. Biophys. Acta | pmid:2879568 |
Bjerve KS | Alpha-linolenic acid deficiency in adult women. | 1987 | Nutr. Rev. | pmid:2881237 |
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Urano S et al. | Membrane-stabilizing effect of vitamin E: effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2892491 |
Hwang DH et al. | Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. | 1988 | J. Nutr. | pmid:2895804 |
Arthur JR | Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. | 1988 | J. Nutr. | pmid:2897437 |
Guesnet P et al. | Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. | 1988 | Reprod Nutr Dev | pmid:2897705 |
Koletzko B and Cunnane S | Human alpha-linolenic acid deficiency. | 1988 | Am. J. Clin. Nutr. | pmid:2897782 |
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Garg ML et al. | Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. | 1988 | Biochim. Biophys. Acta | pmid:2901857 |
Khokher MA and Dandona P | The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. | 1988 | Diabetes Res. | pmid:2906578 |
Blasig IE et al. | Effect of troxerutin and methionine on spin trapping of free oxy-radicals. | 1988 | Biomed. Biochim. Acta | pmid:2907855 |
Yamamoto N et al. | Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. | 1988 | J. Lipid Res. | pmid:2903207 |
Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
Simopoulos AP | Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. | 1989 | J. Nutr. | pmid:2564887 |
Bjerve KS | n-3 fatty acid deficiency in man. | 1989 | J Intern Med Suppl | pmid:2565114 |
Sprecher H | Interactions between the metabolism of n-3 and n-6 fatty acids. | 1989 | J Intern Med Suppl | pmid:2565115 |
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Fritsche KL and Johnston PV | Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary alpha-linolenic acid in BALB/c mice. | 1989 | Lipids | pmid:2569149 |
Garg ML et al. | Dietary saturated fat level alters the competition between alpha-linolenic and linoleic acid. | 1989 | Lipids | pmid:2569150 |
Sok DE and Kim MR | The possible role of 9(S)-hydroperoxyoctadecatrienoic acid as a suicide substrate of soybean lipoxygenase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2569867 |
Hashimoto Y et al. | Effect of black-pigmented Bacteroides gingivalis on cytotoxic activity of linolenic acid against mouse macrophages. | 1989 | Kitasato Arch. Exp. Med. | pmid:2570177 |
Sharov VS et al. | Selective sensitization of chemiluminescence resulted from lipid and oxygen radical reactions. | 1989 | Free Radic. Biol. Med. | pmid:2570736 |
Olaf A | Effects of linoleic and alpha linolenic acids intake on blood pressure in man. | 1989 | Prog. Clin. Biol. Res. | pmid:2571995 |
Bourre JM et al. | The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. | 1989 | J. Nutr. | pmid:2576038 |
Bourre JM | [Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function]. | 1989 | Bull. Acad. Natl. Med. | pmid:2576722 |
Biliński T et al. | Superoxide dismutase deficiency and the toxicity of the products of autooxidation of polyunsaturated fatty acids in yeast. | 1989 | Biochim. Biophys. Acta | pmid:2563227 |
Bourre JM et al. | Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. | 1989 | J. Nutr. | pmid:2563284 |
Bjerve KS et al. | alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. | 1989 | Am. J. Clin. Nutr. | pmid:2563625 |
Hagve TA and Sprecher H | Metabolism of long-chain polyunsaturated fatty acids in isolated cardiac myocytes. | 1989 | Biochim. Biophys. Acta | pmid:2563660 |
Romans JR | Alpha-linolenic acid. | 1989 | Lancet | pmid:2563803 |
Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
D'Aquino M et al. | Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2568114 |
Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
Buffière F et al. | Purification and characterization of monoclonal antibodies to alpha-linolenic acid. | 1989 Mar-Apr | J Lipid Mediat | pmid:2485142 |
Hunter JE | n-3 fatty acids from vegetable oils. | 1990 | Am. J. Clin. Nutr. | pmid:1970702 |
Berger A and German JB | Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). | 1990 | Lipids | pmid:1977067 |
Uauy R | Are omega-3 fatty acids required for normal eye and brain development in the human? | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:1978859 |
Hirose M et al. | Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. | 1990 | Carcinogenesis | pmid:2110511 |
Chapkin RS and Carmichael SL | Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. | 1990 | J. Nutr. | pmid:1974284 |
Bourre JM et al. | Nutritional fatty acids control. Composition and function of cerebral membranes. | 1990 | Bibl Nutr Dieta | pmid:1980414 |
Henry MM et al. | Effect of dietary alpha-linolenic acid on equine monocyte procoagulant activity and eicosanoid synthesis. | 1990 | Circ. Shock | pmid:1979759 |
Fritsche KL and Johnston PV | Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. | 1990 | J. Nutr. | pmid:1979807 |
Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
Uauy R and Hoffman DR | Essential fatty acid requirements for normal eye and brain development. | 1991 | Semin. Perinatol. | pmid:1687090 |
McClead RE et al. | The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1676411 |
Kelley DS et al. | Dietary alpha-linolenic acid and immunocompetence in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1670594 |
Hamberg M | Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1671803 |
Cave WT | Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. | 1991 | FASEB J. | pmid:1673664 |
Bjerve KS | Omega 3 fatty acid deficiency in man: implications for the requirement of alpha-linolenic acid and long-chain omega 3 fatty acids. | 1991 | World Rev Nutr Diet | pmid:1675825 |
Henry MM et al. | Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. | 1991 | Am. J. Vet. Res. | pmid:1675842 |
Morris DD et al. | Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. | 1991 | Am. J. Vet. Res. | pmid:1675843 |
Hasler CM et al. | Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. | 1991 | Am. J. Physiol. | pmid:1677533 |
Horii T et al. | Effect of dietary alpha-linolenate on platelet-activating factor production in rat peritoneal polymorphonuclear leukocytes. | 1991 | J. Immunol. | pmid:1679081 |
Papies B et al. | Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1679554 |
Rhodes PG et al. | Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1681044 |
Sakai K and Okuyama H | Effects of a high alpha-linolenate and high linoleate diet on hemolysis and lipid peroxidation of rat erythrocytes. | 1991 | Chem. Pharm. Bull. | pmid:1682062 |
Narisawa T et al. | Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. | 1991 | Jpn. J. Cancer Res. | pmid:1683347 |
Carlson SE et al. | Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. | 1991 | Pediatr. Res. | pmid:1684416 |
Kwon JS et al. | Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. | 1991 | Am. J. Clin. Nutr. | pmid:1677525 |
Chan JK et al. | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. | 1991 | Am. J. Clin. Nutr. | pmid:1673589 |
Dyer JR and Greenwood CE | Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. | 1991 | J. Neurochem. | pmid:1673995 |
Biagi PL et al. | Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. | 1991 | Biochim. Biophys. Acta | pmid:1674661 |
Cunnane SC et al. | Alpha-linolenic acid in humans: direct functional role or dietary precursor? | 1991 Nov-Dec | Nutrition | pmid:1686981 |
Cook HW | Brain metabolism of alpha-linolenic acid during development. | 1991 Nov-Dec | Nutrition | pmid:1686982 |
Wainwright PE | Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development. | 1991 Nov-Dec | Nutrition | pmid:1686983 |
Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
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Noguchi A et al. | Effects of casein and soy-protein on alpha-linolenic acid metabolism in rats. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1363922 |
Cunnane S | Cholesterol lowering by alpha-linolenic acid. | 1992 | Am. J. Clin. Nutr. | pmid:1345883 |
Yamazaki K et al. | Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. | 1992 | Biochim. Biophys. Acta | pmid:1346092 |
Bourre JM et al. | Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. | 1992 | Biochim. Biophys. Acta | pmid:1347458 |
Arbuckle LD and Innis SM | Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. | 1992 | Lipids | pmid:1349717 |
Alsted AL and Høy CE | Fatty acid profiles of brain phospholipid subclasses of rats fed n - 3 polyunsaturated fatty acids of marine or vegetable origin. A two generation study. | 1992 | Biochim. Biophys. Acta | pmid:1350736 |
Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
Fayard JM et al. | Dietary alpha-linolenic acid deficiency and early uterine development in female rats. | 1992 | J. Nutr. | pmid:1352346 |
Simopoulos AP et al. | Common purslane: a source of omega-3 fatty acids and antioxidants. | 1992 | J Am Coll Nutr | pmid:1354675 |
Rabinovitch-Chable H et al. | Purification of lipoxygenase and hydroperoxide dehydrase in flaxseeds: interaction between these enzymatic activities. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1359887 |
Hoffman DR and Uauy R | Essentiality of dietary omega 3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. | 1992 | Lipids | pmid:1362792 |
Seppänen-Laakso T et al. | Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. | 1992 | Br. J. Nutr. | pmid:1362891 |
Sakai K et al. | Lipid lowering effects of high linoleate and high alpha-linolenate diets in rats and mice. Consequence of long-term feedings. | 1992 | Chem. Pharm. Bull. | pmid:1358471 |
Bjerve KS et al. | Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. | 1992 Mar-Apr | Nutrition | pmid:1350473 |
Singer P | Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. | 1992 Mar-Apr | Nutrition | pmid:1350474 |
Holub BJ and Celi B | Relationships of alpha-linolenic acid to platelet fatty acid composition and trans content of cholesterol-free foods. | 1992 Mar-Apr | Nutrition | pmid:1350475 |
Garg ML and Clandinin MT | Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. | 1992 May-Jun | Nutrition | pmid:1356032 |
Sim JS et al. | Alpha-linolenic acid metabolism: the chicken and the egg. | 1992 May-Jun | Nutrition | pmid:1356037 |