Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Azrad M et al. | Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. | 2012 | PLoS ONE | pmid:23285256 |
Wang X et al. | Transcriptome analysis of Sacha Inchi (Plukenetia volubilis L.) seeds at two developmental stages. | 2012 | BMC Genomics | pmid:23256450 |
Pany S et al. | PKC activation by resveratrol derivatives with unsaturated aliphatic chain. | 2012 | PLoS ONE | pmid:23285216 |
Vanden Heuvel JP et al. | Mechanistic examination of walnuts in prevention of breast cancer. | 2012 | Nutr Cancer | pmid:23061909 |
Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
Kim DH et al. | Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. | 2012 | Yonsei Med. J. | pmid:23074118 |
Pan A et al. | α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. | 2012 | Am. J. Clin. Nutr. | pmid:23076616 |
Barrett E et al. | Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome. | 2012 | PLoS ONE | pmid:23185248 |
Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
Gutla PV et al. | Modulation of plant TPC channels by polyunsaturated fatty acids. | 2012 | J. Exp. Bot. | pmid:23105130 |
Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
Beck JJ et al. | Generation of the volatile spiroketals conophthorin and chalcogran by fungal spores on polyunsaturated fatty acids common to almonds and pistachios. | 2012 | J. Agric. Food Chem. | pmid:23153034 |
Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
Han SN et al. | Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. | 2012 | J. Nutr. | pmid:23096013 |
Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
Ngaki MN et al. | Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. | 2012 | Nature | pmid:22622584 |
Yang Q et al. | Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. | 2012 | Theor. Appl. Genet. | pmid:22534790 |
von Berlepsch S et al. | The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. | 2012 | Plant Physiol. | pmid:22535424 |
Tyagi A et al. | Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. | 2012 | Br. J. Nutr. | pmid:22243775 |
Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
Raatz SK et al. | Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. | 2012 | Nutr Res | pmid:22260857 |
Demchenko K et al. | Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. | 2012 | Plant Biol (Stuttg) | pmid:21973171 |
Jackson MD et al. | Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. | 2012 | Cancer Causes Control | pmid:21984307 |
Zhang J et al. | Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. | 2012 | J. Nutr. Biochem. | pmid:21658928 |
He ML et al. | Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. | 2012 | J. Anim. Sci. | pmid:22274861 |
Poudyal H et al. | Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. | 2012 | J. Nutr. Biochem. | pmid:21429727 |
Nieman DC et al. | Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. | 2012 | J Altern Complement Med | pmid:22830971 |
Regensburger J et al. | Fatty acids and vitamins generate singlet oxygen under UVB irradiation. | 2012 | Exp. Dermatol. | pmid:22229443 |
Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
Levitan EB et al. | α-Linolenic acid, linoleic acid and heart failure in women. | 2012 | Br. J. Nutr. | pmid:22172525 |
Gupta R and Prabhune AA | Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. | 2012 | Biotechnol. Lett. | pmid:22167634 |
Poudel-Tandukar K et al. | Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. | 2012 | Atherosclerosis | pmid:22153152 |
Zheng MM et al. | Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. | 2012 | Bioresour. Technol. | pmid:22209442 |
Ogawa N et al. | Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. | 2012 | Metab. Clin. Exp. | pmid:22445513 |
Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
Chiu CC et al. | Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. | 2012 | Am. J. Clin. Nutr. | pmid:22218153 |
Lemaitre RN et al. | Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22743310 |
Zhang L et al. | Quantitative genomics of 30 complex phenotypes in Wagyu x Angus Fâ‚ progeny. | 2012 | Int. J. Biol. Sci. | pmid:22745575 |
Fink BD et al. | Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. | 2012 | PLoS ONE | pmid:22745753 |
Egert S et al. | Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. | 2012 | J. Nutr. | pmid:22810989 |
Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
Pham AT et al. | Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. | 2012 | Theor. Appl. Genet. | pmid:22476873 |
Rosa DD et al. | Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. | 2012 | Nutr Cancer | pmid:22483364 |
Karppi J et al. | Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. | 2012 | Nutr Cancer | pmid:22420939 |
Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Bocianowski J et al. | Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. | 2012 | J. Appl. Genet. | pmid:21912934 |
Baars T et al. | Experimental improvement of cow milk fatty acid composition in organic winter diets. | 2012 | J. Sci. Food Agric. | pmid:22173628 |
Chen CY and Inui A | What kind of polyunsaturated fatty acid should we eat to stay healthy? | 2012 | Nutrition | pmid:22658641 |
de Freitas JM et al. | Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. | 2012 | FEMS Yeast Res. | pmid:22846157 |
Gómez-Cortés P et al. | Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. | 2012 | Anal. Chem. | pmid:22662968 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Gerber M | Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. | 2012 | Br. J. Nutr. | pmid:22591896 |
Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
Vyncke KE et al. | Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. | 2012 | Br. J. Nutr. | pmid:22370331 |
Park HG et al. | Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). | 2012 | J. Agric. Food Chem. | pmid:22372442 |
Liu HL et al. | Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. | 2012 | J. Exp. Bot. | pmid:22378946 |
Tu WC et al. | Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities. | 2012 | Biotechnol. Lett. | pmid:22391738 |
Caspar-Bauguil S et al. | Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. | 2012 | Clin Nutr | pmid:22385730 |
Gorissen L et al. | Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. | 2012 | Int. J. Food Microbiol. | pmid:22405353 |
Shinohara N et al. | jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. | 2012 | J Oleo Sci | pmid:22864514 |
Román à et al. | Contribution of the different omega-3 fatty acid desaturase genes to the cold response in soybean. | 2012 | J. Exp. Bot. | pmid:22865909 |
Griffin BA | Goldilocks and the three bonds: new evidence for the conditional benefits of dietary α-linolenic acid in treating cardiovascular risk in the metabolic syndrome. | 2012 | Br. J. Nutr. | pmid:22894910 |
Baxheinrich A et al. | Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. | 2012 | Br. J. Nutr. | pmid:22894911 |
Nam KH and Yoshihara T | Interactions among LOX metabolites regulate temperature-mediated flower bud formation in morning glory (Pharbitis nil). | 2012 | J. Plant Physiol. | pmid:22902207 |
Evans SJ et al. | Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. | 2012 | J Psychiatr Res | pmid:22884424 |
Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
Jiang MH et al. | Comparative GC/MS analysis of essential oils extracted by 3 methods from the bud of Citrus aurantium L. var. amara Engl. | 2011 Nov-Dec | J. Food Sci. | pmid:22416680 |
Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
Gao F et al. | Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21651989 |
Trimarco B et al. | [The Alpha Omega study]. | 2011 Jul-Aug | G Ital Cardiol (Rome) | pmid:21779112 |
Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
Degen C et al. | Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. | 2011 | Biochim. Biophys. Acta | pmid:21889998 |
Jung DM et al. | A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. | 2011 | J. Food Sci. | pmid:22417487 |
Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
Farina EK et al. | Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. | 2011 | J. Nutr. | pmid:21508210 |
Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
de Goede J et al. | Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. | 2011 | PLoS ONE | pmid:21464993 |
Moltó-Puigmartà C et al. | Additional data from our study on fatty acids variations during lactation: correlations between n-3 and n-6 PUFAs in human colostrum, transitional, and mature milk. | 2011 | Clin Nutr | pmid:21470725 |
Huang YQ et al. | Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. | 2011 | Analyst | pmid:21331428 |
Lucas M et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. | 2011 | Am. J. Clin. Nutr. | pmid:21471279 |
Kapich AN et al. | Comparative evaluation of manganese peroxidase- and Mn(III)-initiated peroxidation of C18 unsaturated fatty acids by different methods. | 2011 | Enzyme Microb. Technol. | pmid:22112267 |
Han Y et al. | Dynamic QTL analysis of linolenic acid content in different developmental stages of soybean seed. | 2011 | Theor. Appl. Genet. | pmid:21344183 |
Gong J et al. | Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. | 2011 | J. Nutr. | pmid:22049297 |
Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
Holy EW et al. | Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21571683 |
Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
Leyva DR et al. | The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled trial. | 2011 | Contemp Clin Trials | pmid:21616170 |
Qiu L et al. | Coenzyme Q10 production by Sphingomonas sp. ZUTE03 with novel precursors isolated from tobacco waste in a two-phase conversion system. | 2011 | J. Microbiol. Biotechnol. | pmid:21617346 |
Ash MM et al. | Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters. | 2011 | J Med Food | pmid:21548801 |
Kasuli EG | Are alternative supplements effective treatment for diabetes mellitus? | 2011 | Nutr Clin Pract | pmid:21586420 |
Xie N et al. | α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. | 2011 | Arch. Med. Res. | pmid:21722811 |
Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |