Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
Ferretti A and Flanagan VP | Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888358 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
Li D et al. | Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16716580 |
Blanchard H et al. | Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23579035 |
Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
Papies B et al. | Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1679554 |
Seppänen-Laakso T et al. | Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206485 |
Chavali SR et al. | Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610840 |
Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907139 |
Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
Hanke D et al. | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24140006 |
Vancassel S et al. | Plasma fatty acid levels in autistic children. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487301 |
Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
Hurst S et al. | Dietary fatty acids and arthritis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20189789 |
Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
Schimke I et al. | Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431820 |
Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
Leroy C et al. | Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. | 2017 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:28515017 |
Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
Sravan Kumar G and Das UN | Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150374 |
Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
Singer P et al. | Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. | 1987 | Prostaglandins Leukot Med | pmid:2888133 |
Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
Barceló-Coblijn G and Murphy EJ | Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. | 2009 | Prog. Lipid Res. | pmid:19619583 |
Tinoco J | Dietary requirements and functions of alpha-linolenic acid in animals. | 1982 | Prog. Lipid Res. | pmid:6287500 |
Zöllner N | Dietary linolenic acid in man--an overview. | 1986 | Prog. Lipid Res. | pmid:2892211 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
Quadt JF and ten Hoor F | Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. | 1981 | Prog. Lipid Res. | pmid:6281803 |
Marshall LA and Johnston PV | alpha-Linolenic and linoleic acids and the immune response. | 1981 | Prog. Lipid Res. | pmid:6281806 |
Domenichiello AF et al. | Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? | 2015 | Prog. Lipid Res. | pmid:25920364 |