Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kajikawa M et al. | Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris. | 2004 | Plant Mol. Biol. | pmid:15284491 |
Mariutto M et al. | Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato. | 2014 | Plant Mol. Biol. | pmid:24146221 |
Baudouin E et al. | Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. | 1999 | Plant J. | pmid:10571894 |
O'Neill CM et al. | Two high linolenic mutants of Arabidopsis thaliana contain megabase-scale genome duplications encompassing the FAD3 locus. | 2011 | Plant J. | pmid:21848868 |
Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
Yara A et al. | Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases. | 2007 | Plant Cell Physiol. | pmid:17716996 |
Suzuki M et al. | Endogenous alpha-ketol linolenic acid levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil. | 2003 | Plant Cell Physiol. | pmid:12552145 |
Yamaguchi S et al. | Identification of a component that induces flowering of Lemna among the reaction products of alpha-ketol linolenic acid (FIF) and norepinephrine. | 2001 | Plant Cell Physiol. | pmid:11726704 |
Yokoyama M et al. | Stress-induced factor involved in flower formation of Lemna is an alpha-ketol derivative of linolenic acid. | 2000 | Plant Cell Physiol. | pmid:10750715 |
Küpper FC et al. | Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. | 2009 | Plant Cell Physiol. | pmid:19213737 |
Choi SB et al. | Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11230568 |
Sánchez-Hernández C et al. | Reduced levels of volatile emissions in jasmonate-deficient spr2 tomato mutants favour oviposition by insect herbivores. | 2006 | Plant Cell Environ. | pmid:17080606 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Truitt CL et al. | A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. | 2004 | Plant Cell | pmid:14729912 |
Kunz HH et al. | The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness. | 2009 | Plant Cell | pmid:19794119 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Howe GA et al. | An octadecanoid pathway mutant (JL5) of tomato is compromised in signaling for defense against insect attack. | 1996 | Plant Cell | pmid:8953771 |
Ruiz-López N et al. | The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. | 2009 | Plant Biotechnol. J. | pmid:19702757 |
Park H et al. | Towards the development of a sustainable soya bean-based feedstock for aquaculture. | 2017 | Plant Biotechnol. J. | pmid:27496594 |
Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
Demchenko K et al. | Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. | 2012 | Plant Biol (Stuttg) | pmid:21973171 |
Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |
Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
Christensen KB et al. | Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. | 2010 | Phytother Res | pmid:20222152 |
Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
Lagunas B et al. | A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). | 2013 | Phytochemistry | pmid:23928132 |
Ichihara K and Suda Y | Lipid biosynthesis in developing perilla seeds. | 2003 | Phytochemistry | pmid:12711134 |
Frey M et al. | Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects. | 2004 | Phytochemistry | pmid:15110684 |
Fisher AJ et al. | The biochemical origin of pentenol emissions from wounded leaves. | 2003 | Phytochemistry | pmid:12482451 |
Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
Daligault F et al. | Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris. | 2003 | Phytochemistry | pmid:12877913 |
Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
Tsukada K et al. | Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. | 2010 | Phytochemistry | pmid:20952041 |
Jablonická V et al. | Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. | 2016 | Phytochemistry | pmid:27473012 |
Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
House RL et al. | Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. | 2005 | Physiol. Genomics | pmid:15888570 |
Levant B et al. | Developmental effects of dietary n-3 fatty acids on activity and response to novelty. | 2010 | Physiol. Behav. | pmid:20457171 |
Sampels S et al. | Fatty acid transfer from sow to piglet differs for different polyunsaturated fatty acids (PUFA). | 2011 | Physiol Res | pmid:20945951 |
Paré PW et al. | Elicitors and priming agents initiate plant defense responses. | 2005 | Photosyn. Res. | pmid:16075316 |
Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
Takemura N et al. | Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids. | 2002 | Photochem. Photobiol. | pmid:12511046 |
Brown RO et al. | Comparison of specialized and standard enteral formulas in trauma patients. | 1994 May-Jun | Pharmacotherapy | pmid:7937272 |
Furuno K et al. | Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. | 1998 | Pharmacol. Toxicol. | pmid:9820879 |
Eckert GP et al. | Plant derived omega-3-fatty acids protect mitochondrial function in the brain. | 2010 | Pharmacol. Res. | pmid:20079842 |