Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nguemeni C et al. | Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. | 2010 | Pharmacol. Res. | pmid:20036742 |
Yehuda S | Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine: a new molecule. | 2002 | Pharmacol. Biochem. Behav. | pmid:11900763 |
Rastogi SK and Singh J | Effect of chemical penetration enhancer and iontophoresis on the in vitro percutaneous absorption enhancement of insulin through porcine epidermis. | 2005 | Pharm Dev Technol | pmid:15776817 |
Tattersall AL and Wilkins RJ | Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. | 2008 | Pflugers Arch. | pmid:18204856 |
Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Bongiovanni KD et al. | Neonatal growth rate and development of mice raised on milk transgenically enriched with omega-3 fatty acids. | 2007 | Pediatr. Res. | pmid:17667849 |
Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
Anderson GJ et al. | Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. | 2005 | Pediatr. Res. | pmid:16257925 |
Cunnane SC et al. | Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. | 2006 | Pediatr. Res. | pmid:16326997 |
Carlson SE et al. | Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. | 1991 | Pediatr. Res. | pmid:1684416 |
Mayes C et al. | Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | 2006 | Pediatr. Res. | pmid:16439591 |
de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
Fu Z and Sinclair AJ | Novel pathway of metabolism of alpha-linolenic acid in the guinea pig. | 2000 | Pediatr. Res. | pmid:10709744 |
Perumalsamy H et al. | Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. | 2015 | Parasit Vectors | pmid:25928224 |
Han H et al. | Flaxseed Oil Containing α -Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. | 2015 | Oxid Med Cell Longev | pmid:26180602 |
Lohner S et al. | [Dietary supplementation of obese children with 1000 mg alpha-linolenic acid per day: a placebo-controlled double blind study]. | 2007 | Orv Hetil | pmid:17675277 |
Varga Z | [Omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis]. | 2008 | Orv Hetil | pmid:18375362 |
Celik A et al. | Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450(BM3) from Bacillus megaterium. | 2005 | Org. Biomol. Chem. | pmid:16032346 |
Nonaka H et al. | Stereoselective synthesis of epi-jasmonic acid, tuberonic acid, and 12-oxo-PDA. | 2010 | Org. Biomol. Chem. | pmid:20844792 |
Perga ME et al. | Are cyanobacterial blooms trophic dead ends? | 2013 | Oecologia | pmid:23129401 |
Djoussé L et al. | Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. | 2006 | Obesity (Silver Spring) | pmid:16571856 |
Faintuch J et al. | Systemic inflammation in morbidly obese subjects: response to oral supplementation with alpha-linolenic acid. | 2007 | Obes Surg | pmid:17546842 |
Lund AS et al. | N-3 polyunsaturated fatty acids, body fat and inflammation. | 2013 | Obes Facts | pmid:23970146 |
Cunnane SC et al. | Alpha-linolenic acid in humans: direct functional role or dietary precursor? | 1991 Nov-Dec | Nutrition | pmid:1686981 |
Cook HW | Brain metabolism of alpha-linolenic acid during development. | 1991 Nov-Dec | Nutrition | pmid:1686982 |
Wainwright PE | Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development. | 1991 Nov-Dec | Nutrition | pmid:1686983 |
Schubert R et al. | Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. | 2007 | Nutrition | pmid:17664057 |
Monge-Rojas R et al. | Changes in dietary intake and food sources of saturated and cis and trans unsaturated fatty acids in Costa Rican adolescents: 1996 versus 2006. | 2013 | Nutrition | pmid:23298971 |
Gatchalian-Yee M et al. | Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. | 1997 Jul-Aug | Nutrition | pmid:9263255 |
Sartorelli DS et al. | Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians. | 2010 | Nutrition | pmid:19647413 |
Burke PA et al. | Conditionally essential fatty acid deficiencies in end-stage liver disease. | 1999 | Nutrition | pmid:10319364 |
Ikeda A et al. | Effects of intravenous perilla oil emulsion on nutritional status, polyunsaturated fatty acid composition of tissue phospholipids, and thromboxane A2 production in streptozotocin-induced diabetic rats. | 1995 Sep-Oct | Nutrition | pmid:8748197 |
Muñoz SE et al. | Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. | 1999 | Nutrition | pmid:10198915 |
Moore CS et al. | Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. | 2006 | Nutrition | pmid:17027436 |
Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
Garg ML and Clandinin MT | Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. | 1992 May-Jun | Nutrition | pmid:1356032 |
Boudreau MD et al. | Alpha-linolenic acid and prostaglandin synthesis. | 1992 May-Jun | Nutrition | pmid:1356033 |
Emken EA et al. | Human metabolic studies with deuterated alpha-linolenic acid. | 1992 May-Jun | Nutrition | pmid:1356034 |
Kelley DS | Alpha-linolenic acid and immune response. | 1992 May-Jun | Nutrition | pmid:1356035 |
Dick TA and Yang X | Alpha-linolenic acid metabolism in fish. | 1992 May-Jun | Nutrition | pmid:1356036 |
Sim JS et al. | Alpha-linolenic acid metabolism: the chicken and the egg. | 1992 May-Jun | Nutrition | pmid:1356037 |
Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
Chen CY and Inui A | What kind of polyunsaturated fatty acid should we eat to stay healthy? | 2012 | Nutrition | pmid:22658641 |