alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Scherhag R et al. Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. 1982 Prostaglandins pmid:6285420
Marshall LA and Johnston PV alpha-Linolenic and linoleic acids and the immune response. 1981 Prog. Lipid Res. pmid:6281806
Quadt JF and ten Hoor F Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. 1981 Prog. Lipid Res. pmid:6281803
Torinuki W et al. Chemiluminescence of UV-irradiated linolenic acid and squalene. 1982 Tohoku J. Exp. Med. pmid:6280339
Dusting GJ et al. Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats. 1981 Sep-Oct Clin. Exp. Pharmacol. Physiol. pmid:6276057
Yoshino M and Murakami K Effect of spermine on the inhibition by fatty acid on AMP deaminase reaction as a control system of the adenylate energy charge in yeast. 1981 Biochem. Biophys. Res. Commun. pmid:6272814
Cowey CB et al. Tissue distribution, uptake, and requirement for alpha-tocopherol of rainbow trout (Salmo gairdneri) fed diets with a minimal content of unsaturated fatty acids. 1981 J. Nutr. pmid:6268765
Vergroesen AJ et al. Cardiovascular effects of linoleic acid. 1980 Prog Food Nutr Sci pmid:6256818
François M et al. [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. 1980 Ann Nutr Aliment pmid:6254422
Budowski P et al. [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. 1980 Ann Nutr Aliment pmid:6254420
Poisson JP and Blond JP [Effect of supplementation with gamma-linolenic acid on the fatty acid composition of lipids from the liver and plasma in the diabetic rat]. 1983 Arch. Int. Physiol. Biochim. pmid:6204605
Renaud S and Nordøy A "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. 1983 Lancet pmid:6133188
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Codde JP et al. Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. 1984 J. Hypertens. pmid:6099384
Cocchi M et al. Effect of C 18:3 (n-3) dietary supplementation on the fatty acid composition of the rat brain. 1984 Acta Vitaminol. Enzymol. pmid:6098183
Hagve TA and Christophersen BO Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. 1984 Biochim. Biophys. Acta pmid:6093889
Golbeck JH and Warden JT Interaction of linolenic acid with bound quinone molecules in Photosystem II. Time-resolved optical and electron spin resonance studies. 1984 Biochim. Biophys. Acta pmid:6093871
Osipov AN et al. [Study of radicals formed in the interaction of organic hydroperoxides with ferric ions using the spin trap method]. 1984 Jul-Aug Biofizika pmid:6091781
Bolton-Smith C et al. Comparative aspects of omega-3 and omega-6 polyunsaturated fatty acids in rabbits and rats: effects on platelet function, thromboxane and prostacyclin generation, tissue phospholipid fatty acids and membrane fluidity. 1984 Br J Clin Pract Suppl pmid:6091719
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Furukawa M et al. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. 1984 Biochim. Biophys. Acta pmid:6089906
Jones DB et al. Glucose, insulin and platelet fatty acids following myocardial infarction: an association with infarct size. 1987 Jul-Aug Diabete Metab pmid:3315767
pmid:29459511
pmid:29407798
pmid:29311522
pmid:29232610
Du H et al. Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. 2017 J Oleo Sci pmid:29129896
Blasig IE et al. Effect of troxerutin and methionine on spin trapping of free oxy-radicals. 1988 Biomed. Biochim. Acta pmid:2907855
Khokher MA and Dandona P The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. 1988 Diabetes Res. pmid:2906578
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Yamamoto N et al. Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. 1988 J. Lipid Res. pmid:2903207
Garg ML et al. Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. 1988 Biochim. Biophys. Acta pmid:2901857
Fan WX [Alpha-linolenic acid and its metabolites EPA and DHA]. 1988 Sheng Li Ke Xue Jin Zhan pmid:2901141
Huang YS et al. Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding. 1987 Biochem. Int. pmid:2898942
Homayoun P et al. Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet. 1988 J. Neurochem. pmid:2898007
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
Koletzko B and Cunnane S Human alpha-linolenic acid deficiency. 1988 Am. J. Clin. Nutr. pmid:2897782
Guesnet P et al. Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. 1988 Reprod Nutr Dev pmid:2897705
Astorg PO and Chevalier J Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid. 1987 Lipids pmid:2897610
Arthur JR Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. 1988 J. Nutr. pmid:2897437
pmid:28965514
Hwang DH et al. Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. 1988 J. Nutr. pmid:2895804
Chander A and Fisher AB Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. 1988 Biochim. Biophys. Acta pmid:2893643
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Urano S et al. Membrane-stabilizing effect of vitamin E: effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes. 1988 Biochem. Biophys. Res. Commun. pmid:2892491
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Zöllner N Dietary linolenic acid in man--an overview. 1986 Prog. Lipid Res. pmid:2892211
Whitcomb RW et al. Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. 1988 J. Clin. Invest. pmid:2891726
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2890285