Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Umezawa M et al. | High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. | 1999 | J. Nutr. | pmid:10024623 |
Bourre JM et al. | Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats. | 1999 Jan-Feb | Audiology | pmid:10052831 |
Giovannini M et al. | The role of dietary polyunsaturated fatty acids during the first 2 years of life. | 1998 | Early Hum. Dev. | pmid:10102658 |
Pitt B | Results of recent trials on the progression of coronary artery disease and recurrent ischemic events: implications for interventional cardiology. | 1994 | J Interv Cardiol | pmid:10155198 |
Birch DG | Retinal degeneration in retinitis pigmentosa and neuronal ceroid lipofuscinosis: An overview. | 1999 | Mol. Genet. Metab. | pmid:10191129 |
Muñoz SE et al. | Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. | 1999 | Nutrition | pmid:10198915 |
Connor WE | Alpha-linolenic acid in health and disease. | 1999 | Am. J. Clin. Nutr. | pmid:10232618 |
Li D et al. | Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. | 1999 | Am. J. Clin. Nutr. | pmid:10232625 |
Hu FB et al. | Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. | 1999 | Am. J. Clin. Nutr. | pmid:10232627 |
Billman GE et al. | Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. | 1999 | Circulation | pmid:10318669 |
Burke PA et al. | Conditionally essential fatty acid deficiencies in end-stage liver disease. | 1999 | Nutrition | pmid:10319364 |
Haggarty P et al. | Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. | 1999 | Biol. Neonate | pmid:10325438 |
Ihara-Watanabe M et al. | Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10327618 |
Hun CS et al. | Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334920 |
MartÃn M et al. | Antisense-mediated depletion of potato leaf omega3 fatty acid desaturase lowers linolenic acid content and reduces gene activation in response to wounding. | 1999 | Eur. J. Biochem. | pmid:10336609 |
Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
Bhatia KS and Singh J | Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis. | 1999 | Int J Pharm | pmid:10370194 |
Abedin L et al. | The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. | 1999 | Lipids | pmid:10380119 |