Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid:28017961 | ||||
pmid:28063950 | ||||
Senftleber NK et al. | Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. | 2017 | Nutrients | pmid:28067815 |
pmid:28075566 | ||||
pmid:28088290 | ||||
GarcÃa-Vico L et al. | Volatile Compound Profiling by HS-SPME/GC-MS-FID of a Core Olive Cultivar Collection as a Tool for Aroma Improvement of Virgin Olive Oil. | 2017 | Molecules | pmid:28098834 |
pmid:28104576 | ||||
Mirabi P et al. | The role of fatty acids on ICSI outcomes: a prospective cohort study. | 2017 | Lipids Health Dis | pmid:28109274 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
pmid:28109600 | ||||
Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
pmid:28132119 | ||||
Mao Y et al. | Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. | 2017 | J. Food Sci. | pmid:28135396 |
Ando Y et al. | Alpha Linolenic Acid-enriched Diacylglycerol Consumption Enhances Dietary Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trial. | 2017 | J Oleo Sci | pmid:28154349 |
pmid:28157380 | ||||
pmid:28162041 | ||||
pmid:28185855 | ||||
Yamanaka N et al. | Alpha-Linolenic Acid-Enriched Diacylglycerol Oil Suppresses the Postprandial Serum Triglyceride Level-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:28202845 |
Marmon S et al. | Two Acyltransferases Contribute Differently to Linolenic Acid Levels in Seed Oil. | 2017 | Plant Physiol. | pmid:28235891 |
pmid:28237085 | ||||
pmid:28242340 | ||||
pmid:28260396 | ||||
pmid:28263808 | ||||
pmid:28270444 | ||||
Lefort N et al. | Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. | 2017 | Nutrients | pmid:28287415 |
pmid:28303390 | ||||
pmid:28324248 | ||||
pmid:28345766 | ||||
Veselinovic M et al. | Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. | 2017 | Nutrients | pmid:28346333 |
pmid:28357649 | ||||
Burak C et al. | Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. | 2017 | Br. J. Nutr. | pmid:28366181 |
pmid:28367773 | ||||
Guo Q et al. | Highly sensitive method for the quantification of trans-linolenic acid isomers in trilinolenin of edible oils using an ionic liquid capillary column. | 2017 | J. Sci. Food Agric. | pmid:28369919 |
pmid:28374423 | ||||
pmid:28380598 | ||||
Lodolini EM et al. | Oil Characteristics of Four Palestinian Olive Varieties. | 2017 | J Oleo Sci | pmid:28381771 |
Zheng JS et al. | Genetic Risk Score of Nine Type 2 Diabetes Risk Variants that Interact with Erythrocyte Phospholipid Alpha-Linolenic Acid for Type 2 Diabetes in Chinese Hans: A Case-Control Study. | 2017 | Nutrients | pmid:28398239 |
Bentrad N et al. | Identification and evaluation of antibacterial agents present in lipophilic fractions isolated from sub-products of Phoenix dactilyfera. | 2017 | Nat. Prod. Res. | pmid:28403631 |
pmid:28406725 | ||||
pmid:28410665 | ||||
pmid:28410669 | ||||
pmid:28418808 | ||||
Kim H et al. | Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. | 2017 | Nutr J | pmid:28420388 |
pmid:28465188 | ||||
pmid:28468892 | ||||
pmid:28481011 | ||||
pmid:28504119 | ||||
Leroy C et al. | Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. | 2017 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:28515017 |
pmid:28520897 | ||||
Jovanovski E et al. | The effect of alpha-linolenic acid on glycemic control in individuals with type 2 diabetes: A systematic review and meta-analysis of randomized controlled clinical trials. | 2017 | Medicine (Baltimore) | pmid:28538363 |
Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
Azizova OA et al. | [Initiation of nonenzymatic lipid peroxidation in a Fe2+-ascorbate-linolenate system]. | 1985 Jan-Feb | Biofizika | pmid:2858224 |
pmid:28582540 | ||||
McClead RE et al. | Comparison of the clinical and biochemical effect of increased alpha-linolenic acid in a safflower oil intravenous fat emulsion. | 1985 | J. Pediatr. Gastroenterol. Nutr. | pmid:2859362 |
Nakamura T | Red pigment-forming substances from autoxidized linolenate: identification of prostaglandin-like substances. | 1985 | Lipids | pmid:2859511 |
Becker W et al. | Uptake of radiolabelled alpha-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid-deficient rats--an autoradiographic study. | 1985 | Ann. Nutr. Metab. | pmid:2859826 |
Piconneaux A et al. | [Identification of an atypical polyunsaturated fatty acid present in the liver of rats after the ingestion of heated linseed oil]. | 1985 | C. R. Acad. Sci. III, Sci. Vie | pmid:2859918 |
pmid:28605735 | ||||
Das UN | Antibiotic-like action of essential fatty acids. | 1985 | Can Med Assoc J | pmid:2860965 |
Gutteridge JM et al. | Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. | 1985 | Biochim. Biophys. Acta | pmid:2861853 |
Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
Angkasa D et al. | Inadequate dietary α-linolenic acid intake among Indonesian pregnant women is associated with lower newborn weights in urban Jakarta. | 2017 | Asia Pac J Clin Nutr | pmid:28625031 |
pmid:28628798 | ||||
Oki E et al. | Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. | 2017 | Br. J. Nutr. | pmid:28633686 |
pmid:28643621 | ||||
Morisaki N et al. | Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells. | 1985 | J. Lipid Res. | pmid:2864379 |
pmid:28646265 | ||||
Budowski P and Crawford MA | a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. | 1985 | Proc Nutr Soc | pmid:2864692 |
pmid:28651693 | ||||
pmid:28651694 | ||||
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Stymne S and Stobart AK | Involvement of acyl exchange between acyl-CoA and phosphatidylcholine in the remodelling of phosphatidylcholine in microsomal preparations of rat lung. | 1985 | Biochim. Biophys. Acta | pmid:2865978 |
pmid:28660529 | ||||
Booyens J et al. | Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. | 1985 | Med. Hypotheses | pmid:2866439 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Pisanti FA et al. | Effects of bonellin on lipids. | 1986 | Life Sci. | pmid:2869393 |
Johnston NW | Chronic degenerative radiculomyelopathy therapy. | 1985 Dec 21-28 | Vet. Rec. | pmid:2869606 |
Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
pmid:28703829 | ||||
Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
Dyerberg J | Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. | 1986 | Nutr. Rev. | pmid:2872640 |
Cholesterol metabolism and omega-3 polyenes in fish oils. | 1986 | Nutr. Rev. | pmid:2872641 | |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Meadows J et al. | Uric acid protects membranes and linolenic acid from ozone-induced oxidation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2872893 |
Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
Carlin G | Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. | 1985 | J Free Radic Biol Med | pmid:2873164 |
Adam O et al. | Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. | 1986 | J. Lipid Res. | pmid:2873197 |
Takahashi K et al. | Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2874801 |
Towell JF | An animated graphics program depicting the steps in lipid peroxidation. | 1985 | J Free Radic Biol Med | pmid:2875091 |
Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
pmid:28764049 | ||||
Nakamoto S et al. | Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. | 1986 | Biochim. Biophys. Acta | pmid:2876731 |
Acosta PB and Stepnick-Gropper S | Problems related to diet management of maternal phenylketonuria. | 1986 | J. Inherit. Metab. Dis. | pmid:2877116 |
Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
Hiltunen JK et al. | beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. | 1986 | J. Biol. Chem. | pmid:2877988 |
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. | 1986 | Nutr. Rev. | pmid:2878402 | |
Johnston PV and Fritsche KL | Linolenate metabolism. | 1986 | Nutr. Rev. | pmid:2878403 |