alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Adkins Y and Kelley DS | Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. | 2010 | J. Nutr. Biochem. | pmid:20382009 |
| DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
| Field CJ et al. | Effect of feeding a formula supplemented with long-chain polyunsaturated fatty acids for 14 weeks improves the ex vivo response to a mitogen and reduces the response to a soy protein in infants at low risk for allergy. | 2010 | J. Pediatr. Gastroenterol. Nutr. | pmid:20386325 |
| Gracious BL et al. | Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. | 2010 | Bipolar Disord | pmid:20402707 |
| Wall R et al. | Impact of administered bifidobacterium on murine host fatty acid composition. | 2010 | Lipids | pmid:20405232 |
| Massiera F et al. | A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations. | 2010 | J. Lipid Res. | pmid:20410018 |
| Bermudez OI et al. | Dietary intakes and food sources of fat and fatty acids in Guatemalan schoolchildren: a cross-sectional study. | 2010 | Nutr J | pmid:20416064 |
| Campoy C et al. | [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de PediatrÃa. Sociedad Española de GinecologÃa y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. | 2010 | Med Clin (Barc) | pmid:20434734 |
| Levant B et al. | Developmental effects of dietary n-3 fatty acids on activity and response to novelty. | 2010 | Physiol. Behav. | pmid:20457171 |
| Dai J et al. | High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins. | 2010 | Am. J. Clin. Nutr. | pmid:20463041 |
| Burns RN and Moniri NH | Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20471368 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Khiaosa-Ard R et al. | Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. | 2010 | J. Dairy Res. | pmid:20482940 |
| Muller-Delp JM | The role of TREK-1 in cerebrovascular regulation remains elusive: focus on "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20484697 |
| Wien M et al. | Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. | 2010 | Lipids | pmid:20496049 |
| Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
| Begg DP et al. | Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. | 2010 | Hypertens. Res. | pmid:20520615 |
| Lin YH et al. | Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. | 2010 | Am. J. Clin. Nutr. | pmid:20534748 |
| Jhala AJ et al. | Pollen-mediated gene flow in flax (Linum usitatissimum L.): can genetically engineered and organic flax coexist? | 2011 | Heredity (Edinb) | pmid:20551976 |
| Brand A et al. | Retailoring docosahexaenoic acid-containing phospholipid species during impaired neurogenesis following omega-3 alpha-linolenic acid deprivation. | 2010 | J. Neurochem. | pmid:20557429 |
| Szalai G et al. | Effect of nitrogen source in the fertilizing solution on nutritional quality of three members of the Portulaca oleracea aggregate. | 2010 | J. Sci. Food Agric. | pmid:20572061 |
| Taylor CG et al. | Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. | 2010 | J Am Coll Nutr | pmid:20595648 |
| Herdmann A et al. | Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing. | 2010 | J. Agric. Food Chem. | pmid:20597504 |
| Ghamkhar K et al. | Camelina (Camelina sativa (L.) Crantz) as an alternative oilseed: molecular and ecogeographic analyses. | 2010 | Genome | pmid:20616877 |
| McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
| Harauma A et al. | Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition. | 2010 | Lipids | pmid:20625936 |
| Shannon J et al. | Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20630734 |
| Davis PF et al. | Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status. | 2010 | Nutr Neurosci | pmid:20670471 |
| Oya J et al. | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Eur J Clin Nutr | pmid:20683463 |
| Christensen KB et al. | Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.). | 2010 | J Ethnopharmacol | pmid:20696231 |
| Berkov S et al. | Changes in apolar metabolites during in vitro organogenesis of Pancratium maritimum. | 2010 Oct-Nov | Plant Physiol. Biochem. | pmid:20702100 |
| Yoo HJ and HÃ¥kansson K | Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. | 2010 | Anal. Chem. | pmid:20704384 |
| Stumpe M et al. | The moss Physcomitrella patens contains cyclopentenones but no jasmonates: mutations in allene oxide cyclase lead to reduced fertility and altered sporophyte morphology. | 2010 | New Phytol. | pmid:20704658 |
| Nelson TL et al. | Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. | 2011 | Eur J Nutr | pmid:20706728 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Wang S et al. | Temperature dependence of autoxidation of perilla oil and tocopherol degradation. | 2010 | J. Food Sci. | pmid:20722903 |
| Hassan A et al. | An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis. | 2010 | J. Nutr. | pmid:20724486 |
| Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
| Moltó-Puigmartà C et al. | Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants. | 2011 | Clin Nutr | pmid:20800325 |
| Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
| Geleijnse JM et al. | Alpha-linolenic acid: is it essential to cardiovascular health? | 2010 | Curr Atheroscler Rep | pmid:20814766 |
| Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
| McNamara RK et al. | Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817496 |
| Mason JE | By the way, doctor. I am confused about omega-3 fats Are the different types equally good for you? | 2010 | Harv Health Lett | pmid:20821857 |
| Steinritz D et al. | Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. | 2010 | Toxicol. Sci. | pmid:20833707 |
| Miyazawa D et al. | Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. | 2010 | Life Sci. | pmid:20837030 |
| Nonaka H et al. | Stereoselective synthesis of epi-jasmonic acid, tuberonic acid, and 12-oxo-PDA. | 2010 | Org. Biomol. Chem. | pmid:20844792 |
| Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
| Lora KR et al. | Validity and reliability of an omega-3 fatty acid food frequency questionnaire for first-generation Midwestern Latinas. | 2010 | Nutr Res | pmid:20851309 |
| Saha SS and Ghosh M | Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model. | 2010 | Food Chem. Toxicol. | pmid:20851731 |
| Welch AA et al. | Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. | 2010 | Am. J. Clin. Nutr. | pmid:20861171 |
| Kromhout D et al. | n-3 fatty acids and cardiovascular events after myocardial infarction. | 2010 | N. Engl. J. Med. | pmid:20929341 |
| Sampels S et al. | Fatty acid transfer from sow to piglet differs for different polyunsaturated fatty acids (PUFA). | 2011 | Physiol Res | pmid:20945951 |
| Tsukada K et al. | Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. | 2010 | Phytochemistry | pmid:20952041 |
| Huang F et al. | EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner. | 2011 | Br. J. Nutr. | pmid:20955633 |
| Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
| Lau BY et al. | Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. | 2010 | Appl Physiol Nutr Metab | pmid:20962915 |
| Naqvi AZ et al. | n-3 fatty acids and periodontitis in US adults. | 2010 | J Am Diet Assoc | pmid:21034880 |
| Broughton KS et al. | High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. | 2010 | Nutr Res | pmid:21056289 |
| Seltmann MA et al. | Jasmonates during senescence: signals or products of metabolism? | 2010 | Plant Signal Behav | pmid:21057217 |
| Guelzim N et al. | A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. | 2011 | Amino Acids | pmid:21063737 |
| Rodriguez-Leyva D et al. | The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. | 2010 | Can J Cardiol | pmid:21076723 |
| Couëdelo L et al. | Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. | 2011 | Br. J. Nutr. | pmid:21080982 |
| Wu TC et al. | Fatty acid composition of Taiwanese human milk. | 2010 | J Chin Med Assoc | pmid:21093826 |
| Hirose M et al. | Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. | 1990 | Carcinogenesis | pmid:2110511 |
| Sala-Vila A et al. | Carotid and femoral plaque burden is inversely associated with the α-linolenic acid proportion of serum phospholipids in Spanish subjects with primary dyslipidemia. | 2011 | Atherosclerosis | pmid:21111420 |
| Lin YH et al. | Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. | 2011 | J. Nutr. Biochem. | pmid:21111595 |
| Zhao J et al. | Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. | 2011 | J. Nutr. Biochem. | pmid:21129946 |
| Kim M et al. | Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly. | 2010 | Nutr Res | pmid:21130294 |
| Hennessy AA et al. | The health promoting properties of the conjugated isomers of α-linolenic acid. | 2011 | Lipids | pmid:21161605 |
| Imhoff-Kunsch B et al. | Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. | 2011 | J. Nutr. | pmid:21178076 |
| Burdge GC | Polyunsaturated fatty acid intakes and α-linolenic acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:21191139 |
| Vigeolas H et al. | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants. | 2011 | Plant Physiol. | pmid:21205621 |
| Sun P et al. | Effects of different doses of free alpha-linolenic acid infused to the duodenum on the immune function of lactating dairy cows. | 2010 | Arch Anim Nutr | pmid:21214022 |
| Hejazi L et al. | Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. | 2011 | Talanta | pmid:21215858 |
| Senadheera SD et al. | Effects of dietary α-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). | 2011 | J. Agric. Food Chem. | pmid:21222433 |
| Barden A et al. | The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. | 2011 | Free Radic. Res. | pmid:21235285 |
| Metwal N et al. | Influence of debittered, defatted fenugreek seed powder and flaxseed powder on the rheological characteristics of dough and quality of cookies. | 2011 | Int J Food Sci Nutr | pmid:21250900 |
| Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
| Gopinath B et al. | Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease. | 2011 | Br. J. Nutr. | pmid:21255476 |
| Hayirli A et al. | Peripartum responses of dairy cows to prepartal feeding level and dietary fatty acid source. | 2011 | J. Dairy Sci. | pmid:21257060 |
| Dang HT et al. | Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads. | 2011 | Bioorg. Med. Chem. | pmid:21257314 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Qiu J et al. | Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus. | 2011 | PLoS ONE | pmid:21283822 |
| Winnik S et al. | Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. | 2011 | Eur. Heart J. | pmid:21285075 |
| Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
| Padmashree A et al. | Studies on the antioxygenic activity of bitter gourd (Momordica charantia) and its fractions using various in vitro models. | 2011 | J. Sci. Food Agric. | pmid:21302334 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Popescu FD et al. | Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21328065 |
| Huang YQ et al. | Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. | 2011 | Analyst | pmid:21331428 |
| Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
| He ML et al. | Inclusion of flaxseed in hay- and barley silage diets increases alpha-linolenic acid in cow plasma independent of forage type. | 2011 | Lipids | pmid:21336984 |
| Kiyota R et al. | Biosynthetic pathways of the sex pheromone components and substrate selectivity of the oxidation enzymes working in pheromone glands of the fall webworm, Hyphantria cunea. | 2011 | Insect Biochem. Mol. Biol. | pmid:21338674 |
| Han Y et al. | Dynamic QTL analysis of linolenic acid content in different developmental stages of soybean seed. | 2011 | Theor. Appl. Genet. | pmid:21344183 |
| Palmieri-Thiers C et al. | Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. | 2011 | Arch. Biochem. Biophys. | pmid:21345329 |
| Bonaventure G et al. | Herbivore-associated elicitors: FAC signaling and metabolism. | 2011 | Trends Plant Sci. | pmid:21354852 |
| Vos E et al. | n-3 fatty acids and cardiovascular events. | 2011 | N. Engl. J. Med. | pmid:21366485 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
| Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
| Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |