alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Almario RU and Karakas SE Lignan content of the flaxseed influences its biological effects in healthy men and women. 2013 J Am Coll Nutr pmid:23885993
Carter J Flax seed as a source of alpha linolenic acid. 1993 J Am Coll Nutr pmid:7903325
Simopoulos AP Omega-3 fatty acids in inflammation and autoimmune diseases. 2002 J Am Coll Nutr pmid:12480795
Taylor CG et al. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. 2010 J Am Coll Nutr pmid:20595648
West SG et al. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. 2010 J Am Coll Nutr pmid:21677123
Simopoulos AP et al. Common purslane: a source of omega-3 fatty acids and antioxidants. 1992 J Am Coll Nutr pmid:1354675
Lu Z et al. Low linolenate and commercial soybean oils diminish serum HDL cholesterol in young free-living adult females. 1997 J Am Coll Nutr pmid:9430084
Simon JA et al. Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. 2007 J Am Coll Nutr pmid:17906182
Lu M et al. Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. 2007 J Am Coll Nutr pmid:17536124
Patch CS et al. The use of novel foods enriched with long-chain n-3 fatty acids to increase dietary intake: a comparison of methodologies assessing nutrient intake. 2005 J Am Diet Assoc pmid:16321598
Naqvi AZ et al. n-3 fatty acids and periodontitis in US adults. 2010 J Am Diet Assoc pmid:21034880
Cunningham E Does the n-3 fatty acid alpha-linolenic acid have an impact on coronary heart disease? 2005 J Am Diet Assoc pmid:16256769
Van Elswyk ME and Kuratko C Achieving adequate DHA in maternal and infant diets. 2009 J Am Diet Assoc pmid:19248850
Kastner DW and Van Wagoner DR Diet and atrial fibrillation: does α-linolenic acid, a plant derived essential fatty acid, have an impact? 2013 J Am Heart Assoc pmid:23525415
Fretts AM et al. Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. 2013 J Am Heart Assoc pmid:23525429
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Sala-Vila A et al. Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study. 2016 J Am Heart Assoc pmid:26813890
Javadi M et al. The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. 2007 J Anim Physiol Anim Nutr (Berl) pmid:17217386
Nguyen LQ et al. Influence of dietary linseed, fish and coconut oil on growth performance of growing pigs kept on small holdings in central Vietnam. 2004 J Anim Physiol Anim Nutr (Berl) pmid:15189425
Bavelaar FJ et al. Plasma lipids and fatty acid composition in parrots in relation to the intake of alpha-linolenic acid from two feed mixtures. 2005 J Anim Physiol Anim Nutr (Berl) pmid:16138866
Piccione G et al. Daily pattern of some fatty acids in the athletic horse. 2009 J Anim Physiol Anim Nutr (Berl) pmid:19386003
Petzinger C et al. Conversion of α-linolenic acid to long-chain omega-3 fatty acid derivatives and alterations of HDL density subfractions and plasma lipids with dietary polyunsaturated fatty acids in Monk parrots (Myiopsitta monachus). 2014 J Anim Physiol Anim Nutr (Berl) pmid:23600588
Botsoglou E et al. Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. 2013 J Anim Physiol Anim Nutr (Berl) pmid:22716021
Smink W et al. Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. 2013 J Anim Physiol Anim Nutr (Berl) pmid:22463497
Kamvissis VN et al. A novel photometric method for evaluation of the oxidative stability of virgin olive oils. 2008 Jul-Aug J AOAC Int pmid:18727539
Tsuzuki W Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. 2012 Nov-Dec J AOAC Int pmid:23451392
Fukui H et al. 0/w-emulsion of alpha-linolenic acid stabilized with hydrophobized polysaccharide. Its effect on the growth of human colon cancer cells. 1996 J Biomater Sci Polym Ed pmid:8836830
He L et al. Preparation of SiO2/(PMMA/Fe3O4) from monolayer linolenic acid modified Fe3O4 nanoparticles via miniemulsion polymerization. 2009 J Biomed Nanotechnol pmid:20201438
Kirmani ZA et al. Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. 1995 Mar-Apr J Burn Care Rehabil pmid:7775514
Raz R et al. The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. 2009 J Child Adolesc Psychopharmacol pmid:19364294
Wu TC et al. Fatty acid composition of Taiwanese human milk. 2010 J Chin Med Assoc pmid:21093826
Sýkora J et al. High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. 2007 J Chromatogr A pmid:17157864
Guil JL et al. Identification of fatty acids in edible wild plants by gas chromatography. 1996 J Chromatogr A pmid:8589832
Morris JB et al. Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. 2014 J Diet Suppl pmid:25054688
Chen T et al. Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. 2010 J Diet Suppl pmid:22435611
Christensen KB et al. Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.). 2010 J Ethnopharmacol pmid:20696231
Yi LT et al. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. 2013 J Ethnopharmacol pmid:23506995
Cuello S et al. Comparative study of antioxidant and anti-inflammatory activities and genotoxicity of alcoholic and aqueous extracts of four Fabiana species that grow in mountainous area of Argentina. 2011 J Ethnopharmacol pmid:21693175
Carlin G Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. 1985 J Free Radic Biol Med pmid:2873164
Towell JF An animated graphics program depicting the steps in lipid peroxidation. 1985 J Free Radic Biol Med pmid:2875091
Okolo SN et al. The fatty acid composition of human milk in northern Nigeria. 2000 J Hum Lact pmid:11138221
Voigt RG et al. Relationship between omega3 long-chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age. 2002 J Hum Nutr Diet pmid:11972740
Rose HJ et al. Fat intakes of children with PKU on low phenylalanine diets. 2005 J Hum Nutr Diet pmid:16150136
Bjerve KS n-3 fatty acid deficiency in man. 1989 J Intern Med Suppl pmid:2565114
Sprecher H Interactions between the metabolism of n-3 and n-6 fatty acids. 1989 J Intern Med Suppl pmid:2565115
Pitt B Results of recent trials on the progression of coronary artery disease and recurrent ischemic events: implications for interventional cardiology. 1994 J Interv Cardiol pmid:10155198
Buffière F et al. Purification and characterization of monoclonal antibodies to alpha-linolenic acid. 1989 Mar-Apr J Lipid Mediat pmid:2485142
Oh-hashi K et al. Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. 1997 J Lipid Mediat Cell Signal pmid:9524928
Lanson M et al. Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. 1997 J Lipid Mediat Cell Signal pmid:9246607
Lengqvist J et al. Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. 2005 J Mass Spectrom pmid:16258897
Hwang E et al. Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. 2014 J Med Food pmid:25019675
Pari L and Venkateswaran S Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes. 2004 J Med Food pmid:15298769
Ash MM et al. Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters. 2011 J Med Food pmid:21548801
He L et al. Preparation of SiO2/(PMMA/Fe3O4) nanoparticles using linolenic acid as crosslink agent for nucleic acid detection using chemiluminescent method. 2011 J Nanosci Nanotechnol pmid:21449377
Mulder C et al. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease. 2003 J Neural Transm pmid:12898349
Renaud SC Diet and stroke. 2001 J Nutr Health Aging pmid:11458287
Lanzmann-Petithory D Alpha-linolenic acid and cardiovascular diseases. 2001 J Nutr Health Aging pmid:11458289
Cancelo Hidalgo MJ et al. Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. 2006 J Obstet Gynaecol pmid:16753687
Ogawa A et al. Effect of dietary alpha-linolenic acid on vascular reactivity in aorta of spontaneously hypertensive rats. 2009 J Oleo Sci pmid:19367077
Matsuo T and Yagi K Interaction between alpha-linolenic acid-enriched oil and ACE inhibitor concerning the decrease in blood pressure in SHR. 2008 J Oleo Sci pmid:18075218
Ogawa A et al. Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats. 2009 J Oleo Sci pmid:19491530
Dhar P et al. Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. 2006 J Oleo Sci pmid:17693694
Hernandez LR et al. Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. 2015 J Oleo Sci pmid:25757437
Barre DE et al. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. 2008 J Oleo Sci pmid:18391475
Ma T et al. Effect of droplet size on autoxidation rates of methyl linoleate and α-linolenate in an oil-in-water emulsion. 2013 J Oleo Sci pmid:24292352
Herchi W et al. Flaxseed hull: Chemical composition and antioxidant activity during development. 2014 J Oleo Sci pmid:24919478
Reddy YS et al. Study on Synthesis, Characterization and Antiproliferative Activity of Novel Diisopropylphenyl Esters of Selected Fatty Acids. 2016 J Oleo Sci pmid:26666272
Ogata F et al. Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). 2013 J Oleo Sci pmid:23391535
Sengupta A and Ghosh M Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. 2014 J Oleo Sci pmid:24770475
Al-Bishri WM Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. 2013 J Oleo Sci pmid:24005015
Lodolini EM et al. Oil Characteristics of Four Palestinian Olive Varieties. 2017 J Oleo Sci pmid:28381771
Ando Y et al. Alpha Linolenic Acid-enriched Diacylglycerol Consumption Enhances Dietary Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trial. 2017 J Oleo Sci pmid:28154349
Du H et al. Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. 2017 J Oleo Sci pmid:29129896
Ando Y et al. Alpha Linolenic Acid-enriched Diacylglycerol Enhances Postprandial Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trail. 2016 J Oleo Sci pmid:27430386
Saito S et al. Consumption of alpha-Linolenic Acid-enriched Diacylglycerol Reduces Visceral Fat Area in Overweight and Obese Subjects: a Randomized, Double-blind Controlled, Parallel-group Designed Trial. 2016 J Oleo Sci pmid:27321122
Dote S et al. Effects of Triacylglycerol Molecular Species on the Oxidation Behavior of Oils Containing α-Linolenic Acid. 2016 J Oleo Sci pmid:26935948
Barre DE The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. 2007 J Oleo Sci pmid:17898498
Sekine S et al. Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. 2007 J Oleo Sci pmid:17898500
Takeuchi H et al. Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension. 2007 J Oleo Sci pmid:17898501
Murano Y et al. Effect of dietary lard containing higher alpha-linolenic acid on plasma triacylglycerol in rats. 2007 J Oleo Sci pmid:17898502
Shinohara N et al. jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. 2012 J Oleo Sci pmid:22864514
Santos FS et al. Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. 2012 J Pediatr Adolesc Gynecol pmid:22840939
Ruiz-Rodriguez A et al. Recent trends in the advanced analysis of bioactive fatty acids. 2010 J Pharm Biomed Anal pmid:19525080
Kajita M et al. Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. 2000 J Pharm Sci pmid:10980499
Able JA et al. Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. 2014 J Psychiatr Res pmid:24360505
Evans SJ et al. Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. 2012 J Psychiatr Res pmid:22884424
McNamara RK et al. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. 2009 J Psychiatr Res pmid:18986658
Kreider RB et al. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. 2002 J Strength Cond Res pmid:12173945
Furono K et al. Effects of metal ions on lipid peroxidation in cultured rat hepatocytes loaded with alpha-linolenic acid. 1996 J Toxicol Environ Health pmid:8642620
Wei M et al. Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. 2013 J Tradit Chin Med pmid:23789212
Padilla MN et al. Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. 2009 J. Agric. Food Chem. pmid:19722522
Myung K et al. Interaction with and effects on the profile of proteins of Botrytis cinerea by C6 aldehydes. 2007 J. Agric. Food Chem. pmid:17323971
Destaillats F et al. Metabolites of conjugated isomers of alpha-linolenic acid (CLnA) in the rat. 2005 J. Agric. Food Chem. pmid:15740017
Liu CG et al. Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan. 2005 J. Agric. Food Chem. pmid:15740066
Pérez-Gilabert M et al. Purification and partial characterization of lipoxygenase from desert truffle (Terfezia claveryi Chatin) ascocarps. 2005 J. Agric. Food Chem. pmid:15853417
Clapham WM et al. Fatty acid composition of traditional and novel forages. 2005 J. Agric. Food Chem. pmid:16366696
Salas JJ et al. Impact of the suppression of lipoxygenase and hydroperoxide lyase on the quality of the green odor in green leaves. 2005 J. Agric. Food Chem. pmid:15740054
Liu Q et al. Influence of linolenic acid content on the oxidation of milk fat. 2010 J. Agric. Food Chem. pmid:20175540
Fukushige H and Hildebrand DF A simple and efficient system for green note compound biogenesis by use of certain lipoxygenase and hydroperoxide lyase sources. 2005 J. Agric. Food Chem. pmid:16104814
Cao Y et al. Identification and characterization of conjugated linolenic acid isomers by Ag+-HPLC and NMR. 2006 J. Agric. Food Chem. pmid:17117784