Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. | 1995 | J. Anim. Sci. | pmid:7592082 |
Wijkander J et al. | 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. | 1995 | J. Biol. Chem. | pmid:7592874 |
Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |
Lok E et al. | The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice. | 1995 | Cancer Lett. | pmid:7600535 |
Sugihara N et al. | High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616398 |
Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Weisinger HS et al. | Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. | 1995 | Lipids | pmid:7637569 |
Guo W and Hamilton JA | Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. | 1995 | Biophys. J. | pmid:7647242 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
Saito M | Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. | 1994 | Ann. Nutr. Metab. | pmid:7702359 |
Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
Saradhi PP et al. | Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7726821 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
Uauy-Dagach R et al. | Essential fatty acid metabolism and requirements for LBW infants. | 1994 | Acta Paediatr Suppl | pmid:7734797 |
Decsi T et al. | Essential fatty acids in full term infants fed breast milk or formula. | 1995 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:7743279 |
Numata M | [Antitumor effects of alpha-linolenic acid on the human tumor transplanted in nude mice and on the metastasis of Vx-7 tumor in rabbit]. | 1995 | Hokkaido Igaku Zasshi | pmid:7744366 |
Kumar GS and Das UN | Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | 1995 | Cancer Lett. | pmid:7757958 |
Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
Cunnane SC et al. | Nutritional attributes of traditional flaxseed in healthy young adults. | 1995 | Am. J. Clin. Nutr. | pmid:7825540 |
Oulhaj H et al. | [Utilization of linoleate and alpha-linolenate in peritubular cells and Sertoli cells in culture]. | 1994 | C. R. Seances Soc. Biol. Fil. | pmid:7834508 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Ghafoorunissa | Dietary lipids and heart disease--the Indian context. | 1994 Nov-Dec | Natl Med J India | pmid:7841878 |
Yuasa H et al. | Gastric emptying-limited oral absorption of alpha-linolenic acid administered as a milk fat-globule membrane (MFGM) emulsion in rats. | 1994 | Biol. Pharm. Bull. | pmid:7841950 |
Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
Kojima S et al. | Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. | 1994 Sep-Oct | Anticancer Res. | pmid:7847820 |
Goré J et al. | Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. | 1994 | Lipids | pmid:7861937 |
Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
Moore SA | Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. | 1994 | World Rev Nutr Diet | pmid:7871814 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Kardinaal AF et al. | Relations between antioxidant vitamins in adipose tissue, plasma, and diet. | 1995 | Am. J. Epidemiol. | pmid:7879788 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Wang N and Anderson RE | Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. | 1993 | Biochemistry | pmid:7903049 |
Cao J et al. | Inhibition of fatty acid delta 6- and delta 5-desaturation by cyclopropene fatty acids in rat liver microsomes. | 1993 | Biochim. Biophys. Acta | pmid:7903050 |
Bierenbaum ML et al. | Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. | 1993 | J Am Coll Nutr | pmid:7903324 |
Carter J | Flax seed as a source of alpha linolenic acid. | 1993 | J Am Coll Nutr | pmid:7903325 |
Tang AB et al. | Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. | 1993 | Lipids | pmid:7904040 |
Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
Jiang Z and Sim JS | Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. | 1993 Nov-Dec | Nutrition | pmid:7906572 |
Saad Aida MA et al. | Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part I. Serum unsaturated fatty acids. | 1993 | Nahrung | pmid:7907168 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Lockwood K et al. | Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7908519 |
Uauy R et al. | Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. | 1994 | J. Pediatr. | pmid:7908693 |
Mourente G and Tocher DR | In vivo metabolism of [1-14C]linolenic acid (18:3(n-3)) and [1-14C]eicosapentaenoic acid (20:5(n-3)) in a marine fish: time-course of the desaturation/elongation pathway. | 1994 | Biochim. Biophys. Acta | pmid:7908832 |
Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
Zakhariv OIa and Ianovych VH | [Use of [1-14C]linolenic acid in lipid synthesis in ruminant tissues during the prenatal and postnatal periods of development in vitro]. | 1993 Sep-Oct | Ukr. Biokhim. Zh. | pmid:7909179 |
Grandgirard A et al. | Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. | 1994 | Lipids | pmid:7909911 |
Laethem RM et al. | Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. | 1994 | Biochim. Biophys. Acta | pmid:7910485 |
Ohta S et al. | Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. | 1994 | Bull Environ Contam Toxicol | pmid:7910498 |
Franke AA et al. | Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. | 1994 | Cancer Lett. | pmid:7910514 |
Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
McKeigue P | Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? | 1994 | Lancet | pmid:7911171 |
de Lorgeril M et al. | Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. | 1994 | Lancet | pmid:7911176 |
Yehuda S et al. | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. | 1994 | Eur. J. Pharmacol. | pmid:7911428 |
Chen Q and Nilsson A | Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. | 1994 | J. Lipid Res. | pmid:7911819 |
Caffieri S et al. | Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:7912265 |
Lapenna D et al. | Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. | 1994 | Free Radic. Res. | pmid:7912612 |
Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Crastes de Paulet A et al. | [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. | 1994 | Bull. Acad. Natl. Med. | pmid:7913655 |
Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
Mantzioris E et al. | Mediterranean diet. | 1994 | Lancet | pmid:7914327 |
Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
Yamaguchi Y et al. | Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. | 1994 | Magnes Res | pmid:7914418 |
Bougnoux P et al. | alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. | 1994 | Br. J. Cancer | pmid:7914425 |
Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
Cunnane SC and McIntosh D | alpha-Linolenic acid and reduction of cardiac deaths. | 1994 | Lancet | pmid:7914995 |
Marckmann P and Jespersen J | alpha-Linolenic acid and reduction of cardiac deaths. | 1994 | Lancet | pmid:7914996 |
Ulmann L et al. | Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7915142 |
Watanabe S et al. | A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. | 1994 | J. Nutr. | pmid:7916376 |
Winters BL et al. | Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. | 1994 | J. Nutr. | pmid:7916377 |
Rice RD | Mediterranean diet. | 1994 | Lancet | pmid:7916429 |
Ackman RG | alpha-Linolenic acid in human adipose tissue. | 1994 | Lipids | pmid:7916440 |
Stillwell W et al. | Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. | 1994 | Biochim. Biophys. Acta | pmid:7918592 |
Mlakar A and Spiteller G | Reinvestigation of lipid peroxidation of linolenic acid. | 1994 | Biochim. Biophys. Acta | pmid:7918602 |
del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
Yuasa H et al. | Evaluation of milk fat-globule membrane (MFGM) emulsion for oral administration: absorption of alpha-linolenic acid in rats and the effect of emulsion droplet size. | 1994 | Biol. Pharm. Bull. | pmid:7920450 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Ikeda I et al. | alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. | 1994 | J. Nutr. | pmid:7931698 |
Brown RO et al. | Comparison of specialized and standard enteral formulas in trauma patients. | 1994 May-Jun | Pharmacotherapy | pmid:7937272 |
Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
Yang JG et al. | Determination of the contents of EPA and DHA and lipid constituents in main fresh water fishes in China. | 1994 | J. Tongji Med. Univ. | pmid:7966518 |
Bourre JM et al. | Function of dietary polyunsaturated fatty acids in the nervous system. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8093816 |
Nakashima Y et al. | Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | 1993 | J. Lipid Res. | pmid:8094090 |
Hanai T et al. | Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. | 1993 | J. Surg. Res. | pmid:8094103 |
Ferrari-Iliou R et al. | In vitro photodynamic lipid peroxidation of total lipophilic extracts from leaves of bean plants. | 1993 | Biochim. Biophys. Acta | pmid:8094299 |
Cantrill RC et al. | Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells. | 1993 | Lipids | pmid:8096621 |