alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Azrad M et al. Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. 2012 PLoS ONE pmid:23285256
Wang X et al. Transcriptome analysis of Sacha Inchi (Plukenetia volubilis L.) seeds at two developmental stages. 2012 BMC Genomics pmid:23256450
Pany S et al. PKC activation by resveratrol derivatives with unsaturated aliphatic chain. 2012 PLoS ONE pmid:23285216
Astiz M et al. Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. 2012 Lipids pmid:22476691
Macášek J et al. Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. 2012 Nutr Cancer pmid:23061902
Vanden Heuvel JP et al. Mechanistic examination of walnuts in prevention of breast cancer. 2012 Nutr Cancer pmid:23061909
Vedtofte MS et al. The role of essential fatty acids in the control of coronary heart disease. 2012 Curr Opin Clin Nutr Metab Care pmid:23037902
Kim DH et al. Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. 2012 Yonsei Med. J. pmid:23074118
Pan A et al. α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. 2012 Am. J. Clin. Nutr. pmid:23076616
Hennessy AA et al. The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. 2012 Lipids pmid:22160449
Järvinen R et al. Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. 2012 Eur J Clin Nutr pmid:22113249
Nandi S et al. Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. 2012 Theriogenology pmid:22115808
Gutla PV et al. Modulation of plant TPC channels by polyunsaturated fatty acids. 2012 J. Exp. Bot. pmid:23105130
Jernerén F et al. Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. 2012 Lipids pmid:22048860
Sauerwald UC et al. Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22008957
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Vecchio AJ et al. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. 2012 J. Biol. Chem. pmid:22637474
Jiang M et al. [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. 2012 Wei Sheng Yan Jiu pmid:22611923
Ngaki MN et al. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. 2012 Nature pmid:22622584
Yang Q et al. Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. 2012 Theor. Appl. Genet. pmid:22534790
von Berlepsch S et al. The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. 2012 Plant Physiol. pmid:22535424
Tyagi A et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. 2012 Br. J. Nutr. pmid:22243775
Thomas T et al. The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. 2012 Eur J Clin Nutr pmid:22009072
Alessandri JM et al. Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. 2012 Eur J Nutr pmid:21647669
Raatz SK et al. Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. 2012 Nutr Res pmid:22260857
Demchenko K et al. Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. 2012 Plant Biol (Stuttg) pmid:21973171
Jackson MD et al. Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. 2012 Cancer Causes Control pmid:21984307
Zhang J et al. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. 2012 J. Nutr. Biochem. pmid:21658928
Poudyal H et al. Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. 2012 J. Nutr. Biochem. pmid:21429727
Nieman DC et al. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. 2012 J Altern Complement Med pmid:22830971
Regensburger J et al. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. 2012 Exp. Dermatol. pmid:22229443
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Yang G et al. Duodenal infusion of α-linolenic acid affects fatty acid metabolism in the mammary gland of lactating dairy cows. 2012 J. Dairy Sci. pmid:22921622
Umesha SS and Naidu KA Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. 2012 Food Chem pmid:22980881
Gupta R and Prabhune AA Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. 2012 Biotechnol. Lett. pmid:22167634
Poudel-Tandukar K et al. Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. 2012 Atherosclerosis pmid:22153152
Zheng MM et al. Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. 2012 Bioresour. Technol. pmid:22209442
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Chiu CC et al. Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. 2012 Am. J. Clin. Nutr. pmid:22218153
Lemaitre RN et al. Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. 2012 Am. J. Clin. Nutr. pmid:22743310
Zhang L et al. Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F₁ progeny. 2012 Int. J. Biol. Sci. pmid:22745575
Fink BD et al. Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. 2012 PLoS ONE pmid:22745753
Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Moallem U and Zachut M Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. 2012 J. Dairy Sci. pmid:22720961
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Pal M and Ghosh M Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. 2012 Food Chem. Toxicol. pmid:22269903
Pham AT et al. Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. 2012 Theor. Appl. Genet. pmid:22476873
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Ling PR et al. Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. 2012 Metab. Clin. Exp. pmid:22512821
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Bocianowski J et al. Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. 2012 J. Appl. Genet. pmid:21912934
Baars T et al. Experimental improvement of cow milk fatty acid composition in organic winter diets. 2012 J. Sci. Food Agric. pmid:22173628
Erdinest N et al. Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. 2012 Invest. Ophthalmol. Vis. Sci. pmid:22669722
Chen CY and Inui A What kind of polyunsaturated fatty acid should we eat to stay healthy? 2012 Nutrition pmid:22658641
Gómez-Cortés P et al. Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. 2012 Anal. Chem. pmid:22662968
Jin F et al. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. 2012 Plant Foods Hum Nutr pmid:22538527
Gerber M Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. 2012 Br. J. Nutr. pmid:22591896
Tu WC et al. An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). 2012 Biochem. Biophys. Res. Commun. pmid:22640739
Vyncke KE et al. Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. 2012 Br. J. Nutr. pmid:22370331
Park HG et al. Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). 2012 J. Agric. Food Chem. pmid:22372442
Liu HL et al. Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. 2012 J. Exp. Bot. pmid:22378946
Tu WC et al. Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities. 2012 Biotechnol. Lett. pmid:22391738
Caspar-Bauguil S et al. Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. 2012 Clin Nutr pmid:22385730
Gorissen L et al. Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. 2012 Int. J. Food Microbiol. pmid:22405353
Shinohara N et al. jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. 2012 J Oleo Sci pmid:22864514
Román Á et al. Contribution of the different omega-3 fatty acid desaturase genes to the cold response in soybean. 2012 J. Exp. Bot. pmid:22865909
Griffin BA Goldilocks and the three bonds: new evidence for the conditional benefits of dietary α-linolenic acid in treating cardiovascular risk in the metabolic syndrome. 2012 Br. J. Nutr. pmid:22894910
Baxheinrich A et al. Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. 2012 Br. J. Nutr. pmid:22894911
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Jiang MH et al. Comparative GC/MS analysis of essential oils extracted by 3 methods from the bud of Citrus aurantium L. var. amara Engl. 2011 Nov-Dec J. Food Sci. pmid:22416680
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Qu WX et al. Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. 2011 May-Jun Phytochem Anal pmid:20848395
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
Trimarco B et al. [The Alpha Omega study]. 2011 Jul-Aug G Ital Cardiol (Rome) pmid:21779112
Guesnet P and Alessandri JM Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. 2011 Biochimie pmid:20478353
Moltó-Puigmartí C et al. Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants. 2011 Clin Nutr pmid:20800325
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Nelson TL et al. Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. 2011 Eur J Nutr pmid:20706728
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Shchepinov MS et al. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. 2011 Toxicol. Lett. pmid:21906664
Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
Qi J et al. The chloroplast-localized phospholipases D α4 and α5 regulate herbivore-induced direct and indirect defenses in rice. 2011 Plant Physiol. pmid:21984727
Bradbury J Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. 2011 Nutrients pmid:22254110
Degen C et al. Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. 2011 Biochim. Biophys. Acta pmid:21889998
Yalcin H et al. Effect of γ-irradiation on bioactivity, fatty acid compositions and volatile compounds of clary sage seed (Salvia sclarea L.). 2011 J. Food Sci. pmid:22417543
Jung DM et al. A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. 2011 J. Food Sci. pmid:22417487
He L et al. Preparation of SiO2/(PMMA/Fe3O4) nanoparticles using linolenic acid as crosslink agent for nucleic acid detection using chemiluminescent method. 2011 J Nanosci Nanotechnol pmid:21449377
Gopinath B et al. Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. 2011 Am. J. Clin. Nutr. pmid:21411616
Milberg P et al. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. 2011 Heart Rhythm pmid:21459164
López-López I et al. Effect of cooking on the chemical composition of low-salt, low-fat Wakame/olive oil added beef patties with special reference to fatty acid content. 2011 Meat Sci. pmid:21497025
Gorissen L et al. Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. 2011 Commun. Agric. Appl. Biol. Sci. pmid:21539185
Farina EK et al. Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. 2011 J. Nutr. pmid:21508210
Burdge GC Polyunsaturated fatty acid intakes and α-linolenic acid metabolism. 2011 Am. J. Clin. Nutr. pmid:21191139
Vigeolas H et al. Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants. 2011 Plant Physiol. pmid:21205621
Couëdelo L et al. Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. 2011 Br. J. Nutr. pmid:21080982
Lenka SK et al. Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. 2011 Plant Biotechnol. J. pmid:20809928
Holy EW et al. Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. 2011 Arterioscler. Thromb. Vasc. Biol. pmid:21571683
Sakurai K et al. Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice. 2011 Nephron Exp. Nephrol. pmid:21734409
Xie N et al. α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. 2011 Arch. Med. Res. pmid:21722811