alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Attar-Bashi NM et al. Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17275274
Igarashi M et al. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. 2007 J. Lipid Res. pmid:17277380
Zhao G et al. Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. 2007 Am. J. Clin. Nutr. pmid:17284733
Baylin A et al. alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. 2007 Am. J. Clin. Nutr. pmid:17284757
Aboshi T et al. Efficient incorporation of unsaturated fatty acids into volicitin-related compounds in Spodoptera litura (Lepidoptera: Noctuidae). 2007 Biosci. Biotechnol. Biochem. pmid:17284824
Deng YM et al. Anti-asthmatic effects of Perilla seed oil in the guinea pig in vitro and in vivo. 2007 Planta Med. pmid:17315310
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Myung K et al. Interaction with and effects on the profile of proteins of Botrytis cinerea by C6 aldehydes. 2007 J. Agric. Food Chem. pmid:17323971
Norton G et al. Characterisation of recombinant Hevea brasiliensis allene oxide synthase: effects of cycloxygenase inhibitors, lipoxygenase inhibitors and salicylates on enzyme activity. 2007 Plant Physiol. Biochem. pmid:17344058
Vos E et al. alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. 2007 Am. J. Clin. Nutr. pmid:17344517
Shimizu T et al. Effects of alpha-linolenic acid on colonic secretion in rats with experimental colitis. 2007 J. Gastroenterol. pmid:17351801
Ayerza R and Coates W Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. 2007 Ann. Nutr. Metab. pmid:17356263
Dewhurst RJ et al. Apparent recovery of duodenal odd- and branched-chain fatty acids in milk of dairy cows. 2007 J. Dairy Sci. pmid:17369218
Liou YA et al. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. 2007 J. Nutr. pmid:17374659
Conklin SM et al. Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. 2007 Psychiatry Res pmid:17383013
Molkentin J and Giesemann A Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. 2007 Anal Bioanal Chem pmid:17393158
Portolesi R et al. Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. 2007 J. Lipid Res. pmid:17409318
Reinprecht Y et al. Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean (Glycine max (L.) Merrill) germplasm. 2006 Genome pmid:17426766
Giovannucci E et al. Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. 2007 Int. J. Cancer pmid:17450530
Tanaka T et al. Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. 2007 FEBS J. pmid:17451430
Karapanagiotidis IT et al. Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh. 2007 Lipids pmid:17473942
Sánchez-Sampedro A et al. Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy. 2007 J. Biotechnol. pmid:17475356
Kiliç T et al. Fatty acid composition of seeds of some species of Nepeta L. 2007 Nat. Prod. Res. pmid:17487620
Szabó E et al. trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study. 2007 Am. J. Clin. Nutr. pmid:17490969
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090
Sun S et al. Singlet oxygen generation from the decomposition of alpha-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase. 2007 Biochemistry pmid:17497889
Ayalew-Pervanchon A et al. Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17526653
Lu M et al. Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. 2007 J Am Coll Nutr pmid:17536124
Ren J and Chung SH Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. 2007 J. Agric. Food Chem. pmid:17542608
Okuyama H et al. Dietary lipids impacts on healthy ageing. 2007 Lipids pmid:17546469
Faintuch J et al. Systemic inflammation in morbidly obese subjects: response to oral supplementation with alpha-linolenic acid. 2007 Obes Surg pmid:17546842
Ueshima H et al. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. 2007 Hypertension pmid:17548718
Blondeau N et al. Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. 2007 Circ. Res. pmid:17556656
Vaysse-Boué C et al. Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. 2007 Lipids pmid:17564735
Järvenpää S et al. A probiotic, Lactobacillus fermentum ME-3, has antioxidative capacity in soft cheese spreads with different fats. 2007 J. Dairy Sci. pmid:17582099
Lauretani F et al. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. 2007 Eur. J. Neurol. pmid:17594339
Nelson TL et al. Inflammatory markers are not altered by an eight week dietary alpha-linolenic acid intervention in healthy abdominally obese adult males and females. 2007 Cytokine pmid:17613244
Szilágyi A et al. Membrane curvature stress controls the maximal conversion of violaxanthin to zeaxanthin in the violaxanthin cycle--influence of alpha-tocopherol, cetylethers, linolenic acid, and temperature. 2007 Biochim. Biophys. Acta pmid:17618598
Astorg P et al. Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. 2008 Eur J Clin Nutr pmid:17622261
Plourde M and Cunnane SC Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. 2007 Appl Physiol Nutr Metab pmid:17622276
Paschos GK et al. Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. 2007 Eur J Nutr pmid:17623225
Bryan RM et al. Starring TREK-1: the next generation of vascular K+ channels. 2007 Circ. Res. pmid:17641234
Wang S and Zhang A Facile and efficient syntheses of (3Z,6Z,9Z)-3,6,9-nonadecatriene and homologues: pheromone and attractant components of lepidoptera. 2007 J. Agric. Food Chem. pmid:17661482
Schubert R et al. Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. 2007 Nutrition pmid:17664057
Bongiovanni KD et al. Neonatal growth rate and development of mice raised on milk transgenically enriched with omega-3 fatty acids. 2007 Pediatr. Res. pmid:17667849
Lohner S et al. [Dietary supplementation of obese children with 1000 mg alpha-linolenic acid per day: a placebo-controlled double blind study]. 2007 Orv Hetil pmid:17675277
Sato I et al. Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. 2007 J. Vet. Med. Sci. pmid:17675801
Ren J et al. In vivo and in vitro anti-inflammatory activities of alpha-linolenic acid isolated from Actinidia polygama fruits. 2007 Arch. Pharm. Res. pmid:17679548
Dhar P et al. Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. 2006 J Oleo Sci pmid:17693694
Nelson TL et al. Adiponectin levels are reduced, independent of polymorphisms in the adiponectin gene, after supplementation with alpha-linolenic acid among healthy adults. 2007 Metab. Clin. Exp. pmid:17697863
DiRienzo MA et al. Effect of substitution of low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. 2006 Lipids pmid:17707981
Sánchez-Ortiz A et al. Cultivar differences on nonesterified polyunsaturated fatty acid as a limiting factor for the biogenesis of virgin olive oil aroma. 2007 J. Agric. Food Chem. pmid:17708640
Igarashi M et al. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. 2007 J. Lipid Res. pmid:17715424
The power of 3. Omega-3 fatty acids. 2007 Mayo Clin Health Lett pmid:17715541
Zhang W et al. Alpha-linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. 2007 Nutrition pmid:17716867
Yara A et al. Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases. 2007 Plant Cell Physiol. pmid:17716996
Chen J et al. Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. 2007 Exp. Biol. Med. (Maywood) pmid:17720953
Rao SS et al. Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. 2007 Nov-Dec Reprod. Toxicol. pmid:17825521
Lin YH and Salem N Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. 2007 J. Lipid Res. pmid:17876057
Barre DE The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. 2007 J Oleo Sci pmid:17898498
Sekine S et al. Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. 2007 J Oleo Sci pmid:17898500
Takeuchi H et al. Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension. 2007 J Oleo Sci pmid:17898501
Murano Y et al. Effect of dietary lard containing higher alpha-linolenic acid on plasma triacylglycerol in rats. 2007 J Oleo Sci pmid:17898502
Simon JA et al. Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. 2007 J Am Coll Nutr pmid:17906182
Alessandri JM et al. Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. 2008 Lipids pmid:17912567
Mert-Türk F et al. Nitrogen and fungicide applications against Erysiphe cruciferarum affect quality components of oilseed rape. 2008 Mycopathologia pmid:17934794
Pazirandeh S et al. Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. 2007 Nov-Dec JPEN J Parenter Enteral Nutr pmid:17947609
Plourde M et al. Conjugated alpha-linolenic acid isomers in bovine milk and muscle. 2007 J. Dairy Sci. pmid:17954767
Zatonski W et al. Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. 2008 Eur. J. Epidemiol. pmid:17955332
Su M et al. Nano-anatase relieves the inhibition of electron transport caused by linolenic acid in chloroplasts of spinach. 2008 Biol Trace Elem Res pmid:17962910
Kronberg SL et al. Flaxseed treatments to reduce biohydrogenation of alpha-linolenic acid by rumen microbes in cattle. 2007 Lipids pmid:17985170
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Huang H et al. Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18003907
Kaufman M and Wiesman Z Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting. 2007 J. Agric. Food Chem. pmid:18004807
Poureslami R et al. Effect of dietary fat source on the deposition of n-3 polyunsaturated fatty acids in broilers: a whole balance approach. 2007 Commun. Agric. Appl. Biol. Sci. pmid:18018899
Pomponi M and Pomponi M DHA deficiency and Alzheimer's disease. 2008 Clin Nutr pmid:18037538
Cantrell CL et al. Phytotoxic Eremophilanes from Ligularia macrophylla. 2007 J. Agric. Food Chem. pmid:18044832
Nakamura K and Uemura D [Unelucidated biological phenomena]. 2007 Tanpakushitsu Kakusan Koso pmid:18051396
Ben-Shabat S et al. Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. 2007 Drug Dev Ind Pharm pmid:18058312
Zheng Y et al. A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality. 2008 J. Biol. Chem. pmid:18070874
Matsuo T and Yagi K Interaction between alpha-linolenic acid-enriched oil and ACE inhibitor concerning the decrease in blood pressure in SHR. 2008 J Oleo Sci pmid:18075218
Masuelli L et al. Intercalated disk remodeling in delta-sarcoglycan-deficient hamsters fed with an alpha-linolenic acid-enriched diet. 2008 Int. J. Mol. Med. pmid:18097614
Khodadadi I et al. Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. 2008 Arch Iran Med pmid:18154422
Guizy M et al. Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. 2008 J. Mol. Cell. Cardiol. pmid:18155022
Wang L et al. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. 2008 Chem. Biol. Interact. pmid:18155686
Tattersall AL and Wilkins RJ Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. 2008 Pflugers Arch. pmid:18204856
Suji G and Sivakami S Malondialdehyde, a lipid-derived aldehyde alters the reactivity of Cys34 and the esterase activity of serum albumin. 2008 Toxicol In Vitro pmid:18206343
Upchurch RG Fatty acid unsaturation, mobilization, and regulation in the response of plants to stress. 2008 Biotechnol. Lett. pmid:18227974
Ogawa N et al. The vagal afferent pathway does not play a major role in the induction of satiety by intestinal fatty acid in rats. 2008 Neurosci. Lett. pmid:18248897
Flores T et al. Silencing of GmFAD3 gene by siRNA leads to low alpha-linolenic acids (18:3) of fad3-mutant phenotype in soybean [Glycine max (Merr.)]. 2008 Transgenic Res. pmid:18256901
Rashid S et al. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. 2008 Arch. Ophthalmol. pmid:18268213
Fuentes F et al. Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. 2008 Br. J. Nutr. pmid:18275619
Maeda H et al. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. 2008 Plant Cell pmid:18314499
Tanaka T et al. Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. 2008 Naunyn Schmiedebergs Arch. Pharmacol. pmid:18320172
Cui PH et al. Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. 2008 Chem. Phys. Lipids pmid:18339314
DiRienzo MA et al. Effect of substitution of high stearic low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. 2008 Lipids pmid:18365266
Warensjö E et al. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. 2008 Nutr Metab Cardiovasc Dis pmid:18367385
Varga Z [Omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis]. 2008 Orv Hetil pmid:18375362
Chang HH et al. Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice. 2008 Lipids pmid:18386091
Jäger AK et al. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. 2008 Phytother Res pmid:18389471