Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Soppela P and Nieminen M | The effect of wintertime undernutrition on the fatty acid composition of leg bone marrow fats in reindeer (Rangifer tarandus tarandus L.). | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163305 |
Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
Pawlosky RJ et al. | Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. | 2001 | J. Lipid Res. | pmid:11483627 |
Kim E et al. | Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. | 2001 | Ann. Nutr. Metab. | pmid:11463998 |
Cherian G and Sim JS | Maternal dietary alpha-linolenic acid (18:3n-3) alters n-3 polyunsaturated fatty acid metabolism and liver enzyme activity in hatched chicks. | 2001 | Poult. Sci. | pmid:11469652 |
Sharma R et al. | Mulberry moracins: scavengers of UV stress-generated free radicals. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11471743 |
Renaud SC | Diet and stroke. | 2001 | J Nutr Health Aging | pmid:11458287 |
Lanzmann-Petithory D | Alpha-linolenic acid and cardiovascular diseases. | 2001 | J Nutr Health Aging | pmid:11458289 |
Hoffman DR et al. | Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa. | 2001 | J. Lipid Res. | pmid:11518758 |
Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
Trommer H et al. | The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions. | 2001 | Eur J Pharm Biopharm | pmid:11343884 |
Robertson RM and Smaha L | Can a Mediterranean-style diet reduce heart disease? | 2001 | Circulation | pmid:11282917 |
Kris-Etherton P et al. | AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. | 2001 | Circulation | pmid:11282918 |
Marmunti M and Catalá A | Incorporation of 1-(14)C linoleic acid in rat liver nuclei and chromatin fractions. | 2001 | Int. J. Biochem. Cell Biol. | pmid:11311857 |
Dyer JM et al. | Chilling-sensitive, post-transcriptional regulation of a plant fatty acid desaturase expressed in yeast. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11352654 |
Johnson LK et al. | [Diet and secondary prevention of coronary heart disease--are our recommendations good enough?]. | 2001 | Tidsskr. Nor. Laegeforen. | pmid:11354888 |
Williard DE et al. | Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts. | 2001 | J. Lipid Res. | pmid:11290821 |
Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
Spector AA | Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478370 |
Cunnane SC et al. | NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478372 |
Salem N et al. | Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478385 |
Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
Kozachenko AI et al. | Characteristics of beta-carotene-induced inhibition of free radical oxidation of fatty acids with different degree of unsaturation. | 2001 Jul-Aug | Dokl. Biochem. Biophys. | pmid:11665681 |
Kreider RB et al. | Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. | 2002 | J Strength Cond Res | pmid:12173945 |
Schreck U et al. | Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? | 2002 | Strahlenther Onkol | pmid:12122788 |
Jeffrey BG et al. | n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147619 |
Hisha H et al. | Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-taiho-to): stimulatory effects of its fatty acids on hemopoiesis in patients. | 2002 | Stem Cells | pmid:12110700 |
Pratt VC et al. | Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans. | 2002 | Crit. Care Med. | pmid:12163788 |
Weber H | Fatty acid-derived signals in plants. | 2002 | Trends Plant Sci. | pmid:11992827 |
Voigt RG et al. | Relationship between omega3 long-chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age. | 2002 | J Hum Nutr Diet | pmid:11972740 |
Carrié I et al. | Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. | 2002 | Nutr Neurosci | pmid:11929197 |
Anwar F et al. | Analytical characterization of Salicornia bigelovii seed oil cultivated in Pakistan. | 2002 | J. Agric. Food Chem. | pmid:12105947 |
Visioli F and Galli C | Alpha-linolenic acid and cardiovascular disease. | 2002 | Am. J. Clin. Nutr. | pmid:12036822 |
Hamberg M | Biosynthesis of new divinyl ether oxylipins in Ranunculus plants. | 2002 | Lipids | pmid:12030324 |
Haggarty P et al. | The effect of maternal smoking and ethanol on fatty acid transport by the human placenta. | 2002 | Br. J. Nutr. | pmid:12064333 |
Ximenes da Silva A et al. | Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. | 2002 | J. Neurochem. | pmid:12068080 |
Suzuki R et al. | Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054914 |
Ishihara K et al. | Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. | 2002 | Lipids | pmid:12056590 |
Zabrouskov V and Knowles NR | Lipid metabolism during aging of high-alpha-linolenate-phenotype potato tubers. | 2002 | Arch. Biochem. Biophys. | pmid:12051691 |
Renaud S and Lanzmann-Petithory D | Dietary fats and coronary heart disease pathogenesis. | 2002 | Curr Atheroscler Rep | pmid:12361488 |
Murase T et al. | Dietary alpha-linolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice. | 2002 | J. Nutr. | pmid:12368389 |
Acar N et al. | Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. | 2002 | J. Nutr. | pmid:12368410 |
Burdge GC et al. | Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*. | 2002 | Br. J. Nutr. | pmid:12323085 |
Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. | 2002 | Br. J. Nutr. | pmid:12323090 |
Kaup MT et al. | A role for diacylglycerol acyltransferase during leaf senescence. | 2002 | Plant Physiol. | pmid:12177474 |
Renaud SC and Lanzmann-Petithory D | The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. | 2002 | Am. J. Clin. Nutr. | pmid:12324307 |
Acar N et al. | Modification of the monoaminergic neurotransmitters in frontal cortex and hippocampus by dietary trans alpha-linolenic acid in piglets. | 2002 | Neurosci. Lett. | pmid:12383930 |
Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
Weiler HA and Fitzpatrick-Wong SC | Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. | 2002 | J. Nutr. | pmid:12221227 |
Itoh S et al. | Synthesis of the (17R)- and (17S)-isomers of volicitin, an elicitor of plant volatiles contained in the oral secretion of the beet armyworm. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224650 |
Blée E | Impact of phyto-oxylipins in plant defense. | 2002 | Trends Plant Sci. | pmid:12119169 |
Akakabe Y et al. | Enantioselective formation of (R)-9-HPODE and (R)-9-HPOTrE in marine green alga Ulva conglobata. | 2002 | Bioorg. Med. Chem. | pmid:12150862 |
Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |
Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
Petkova-Andonova M et al. | CYP92B1, A cytochrome P450, expressed in petunia flower buds, that catalyzes monooxidation of long-chain fatty acids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400678 |
Szentmihályi K et al. | Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. | 2002 | Bioresour. Technol. | pmid:12003323 |
Araseki M et al. | Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596850 |
Eder K et al. | Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and alpha-linolenic acids in HepG2 cells. | 2002 | J. Nutr. | pmid:12042419 |
Yang X et al. | [Effects of silkworm pupa oil on serum lipids level and platelet function in rats]. | 2002 | Wei Sheng Yan Jiu | pmid:12600031 |
Ghafoorunissa A et al. | Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. | 2002 | Lipids | pmid:12558058 |
Chen J et al. | Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. | 2002 | Nutr Cancer | pmid:12588699 |
López-López A et al. | Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. | 2002 | Eur J Clin Nutr | pmid:12494309 |
Kimura Y | Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. | 2002 | J. Nutr. | pmid:12097695 |
Sinclair AJ et al. | What is the role of alpha-linolenic acid for mammals? | 2002 | Lipids | pmid:12617463 |
Wolff RL | Are trans isomers of alpha-linolenic acid of nutritional significance for certain populations? | 2002 | Lipids | pmid:12617467 |
Lanzmann-Petithory D et al. | Primary prevention of cardiovascular diseases by alpha-linolenic acid. | 2002 | Am. J. Clin. Nutr. | pmid:12450919 |
Takemura N et al. | Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids. | 2002 | Photochem. Photobiol. | pmid:12511046 |
Acar N et al. | FA composition of plasma, red blood cell, and liver phospholipids of newborn piglets fed trans isomers of alpha-linolenic acid. | 2002 | Lipids | pmid:12458619 |
Simopoulos AP | Omega-3 fatty acids in inflammation and autoimmune diseases. | 2002 | J Am Coll Nutr | pmid:12480795 |
Maillard V et al. | Interaction of dietary beta-carotene and alpha-linolenic acid: effect on promotion of experimental mammary tumours. | 2002 | IARC Sci. Publ. | pmid:12484221 |
Dunbar BL and Bauer JE | Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. | 2002 | J. Nutr. | pmid:12042499 |
Kris-Etherton PM et al. | Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. | 2002 | Circulation | pmid:12438303 |
Karvonen HM et al. | Effect of alpha-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. | 2002 | Metab. Clin. Exp. | pmid:12370843 |
Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
Lichtenstein AH et al. | Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects. | 2002 | J. Lipid Res. | pmid:11861668 |
Futakuchi M et al. | Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | 2002 | Cancer Lett. | pmid:11867197 |
Ward AT et al. | Bovine milk fatty acid profiles produced by feeding diets containing solin, flax and canola. | 2002 | J. Dairy Sci. | pmid:12086055 |
Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |
Cahoon EB et al. | Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. | 2002 | Plant Physiol. | pmid:11842164 |
Korotkova M et al. | Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. | 2002 | J. Lipid Res. | pmid:12364559 |
Parmentier HK et al. | Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 2002 | Br. Poult. Sci. | pmid:12365510 |
Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
Itoh A et al. | Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids. | 2002 | J. Biol. Chem. | pmid:12351632 |
Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
Good for the heart but not for the prostate? The alpha-linolenic acid dilemma. | 2002 | Harv Mens Health Watch | pmid:11823168 | |
De Lorgeril M and Salen P | Fish and N-3 fatty acids for the prevention and treatment of coronary heart disease: nutrition is not pharmacology. | 2002 | Am. J. Med. | pmid:11893373 |
Tripathi AK et al. | A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779214 |
Brenna JT | Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844977 |
Infante JP et al. | Straight-chain acyl-CoA oxidase knockout mouse accumulates extremely long chain fatty acids from alpha-linolenic acid: evidence for runaway carousel-type enzyme kinetics in peroxisomal beta-oxidation diseases. | 2002 | Mol. Genet. Metab. | pmid:11855929 |
Tarpila S et al. | The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. | 2002 | Eur J Clin Nutr | pmid:11857049 |
Manthey FA et al. | Processing and cooking effects on lipid content and stability of alpha-linolenic acid in spaghetti containing ground flaxseed. | 2002 | J. Agric. Food Chem. | pmid:11879055 |
Kitajka K et al. | The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11880617 |
Yehuda S | Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine: a new molecule. | 2002 | Pharmacol. Biochem. Behav. | pmid:11900763 |
Lee JY et al. | Antimicrobial synergistic effect of linolenic acid and monoglyceride against Bacillus cereus and Staphylococcus aureus. | 2002 | J. Agric. Food Chem. | pmid:11902977 |
Schwartz Z et al. | 1alpha,25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis. | 2002 | J. Biol. Chem. | pmid:11805100 |
Bemelmans WJ et al. | Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. | 2002 | Am. J. Clin. Nutr. | pmid:11815311 |
Xian M et al. | Production of linolenic acid by Mortierella isabellina grown on octadecanol. | 2002 | Curr. Microbiol. | pmid:11815860 |
Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |