Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Walters D et al. | Antifungal activities of four fatty acids against plant pathogenic fungi. | 2004 | Mycopathologia | pmid:15008350 |
Bloedon LT and Szapary PO | Flaxseed and cardiovascular risk. | 2004 | Nutr. Rev. | pmid:14995053 |
Thiombiano-Coulibaly N et al. | Seasonal and environmental effects on breast milk fatty acids in Burkina Faso and the need to improve the omega 3 PUFA content. | 2003 | Acta Paediatr. | pmid:14971787 |
Agostoni C | The difficult balance between dietary polyunsaturated fatty acids. | 2003 | Acta Paediatr. | pmid:14971782 |
Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
Tsuzuki T et al. | Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. | 2004 | Carcinogenesis | pmid:14963014 |
de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
Mutsvangwa T et al. | Short communication: Effects of a monensin premix on milk fatty acid content during subacute ruminal acidosis in dairy cows. | 2003 | J. Dairy Sci. | pmid:14740842 |
Cabrita AR et al. | Nitrogen supplementation of corn silages. 2. Assessing rumen function using fatty acid profiles of bovine milk. | 2003 | J. Dairy Sci. | pmid:14740840 |
Yoshinaga N et al. | Specific incorporation of L-glutamine into volicitin in the regurgitant of Spodoptera litura. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14730148 |
Truitt CL et al. | A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. | 2004 | Plant Cell | pmid:14729912 |
Fleshner N et al. | Dietary fat and prostate cancer. | 2004 | J. Urol. | pmid:14713748 |
Truitt CL and Paré PW | In situ translocation of volicitin by beet armyworm larvae to maize and systemic immobility of the herbivore elicitor in planta. | 2004 | Planta | pmid:14685859 |
Spence JD et al. | The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress. | 2003 | J Am Coll Nutr | pmid:14684754 |
Dunn JD et al. | Effects of flax supplementation and a combined trenbolone acetate and estradiol implant on circulating insulin-like growth factor-I and muscle insulin-like growth factor-I messenger RNA levels in beef cattle. | 2003 | J. Anim. Sci. | pmid:14677858 |
Hauswirth CB et al. | High omega-3 fatty acid content in alpine cheese: the basis for an alpine paradox. | 2004 | Circulation | pmid:14676141 |
Bazinet RP et al. | Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet. | 2003 | Lipids | pmid:14669969 |
Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
Pawlosky R et al. | n-3 fatty acid metabolism in women. | 2003 | Br. J. Nutr. | pmid:14667193 |
Chuang SS et al. | CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. | 2004 | J. Biol. Chem. | pmid:14660610 |
[Dietary management of lipid disorders. Plant oil protects hearts of diabetic patients]. | 2003 | MMW Fortschr Med | pmid:14655490 | |
Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
de Groot RH et al. | Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive functioning. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643178 |
Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
Trommer H et al. | Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action. | 2003 | J. Pharm. Pharmacol. | pmid:14607020 |
Rabinovitz S et al. | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). | 2004 | Psychoneuroendocrinology | pmid:14604595 |
Abdel-Lateff A et al. | A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. | 2003 | Planta Med. | pmid:14598209 |
Lapillonne A et al. | Plausible mechanisms for effects of long-chain polyunsaturated fatty acids on growth. | 2003 | J. Pediatr. | pmid:14597909 |
Bell MV et al. | Tissue deposition of n-3 FA pathway intermediates in the synthesis of DHA in rainbow trout (Oncorhynchus mykiss). | 2003 | Lipids | pmid:14584600 |
Tavani A et al. | Alpha-linolenic acid and nonfatal acute myocardial infarction. | 2003 | Circulation | pmid:14581393 |
Bellini MJ et al. | Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14580370 |
Vecchini A et al. | Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. | 2004 | J. Lipid Res. | pmid:14563831 |
Bavelaar FJ and Beynen AC | Severity of atherosclerosis in parrots in relation to the intake of alpha-linolenic acid. | 2003 Jul-Sep | Avian Dis. | pmid:14562883 |
Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
Ozawa R | [Herbivore elicitors and plant signaling pathways involved in the production of herbivore-induced plant volatiles]. | 2003 | Tanpakushitsu Kakusan Koso | pmid:14535205 |
Andoh A et al. | N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. | 2003 | Int. J. Mol. Med. | pmid:14533000 |
Ainai T et al. | Efficient total synthesis of 12-oxo-PDA and OPC-8:0. | 2003 | J. Org. Chem. | pmid:14510562 |
Flaxseed oil: healthful or harmful for men? | 2003 | Harv Mens Health Watch | pmid:14505958 | |
Iacazio G | Easy access to various natural keto polyunsaturated fatty acids and their corresponding racemic alcohols. | 2003 | Chem. Phys. Lipids | pmid:14499470 |
PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
CHENG AL et al. | The effect of fat level of the diet on general nutrition. XV. Comparison of the protective effect of linoleic acid and linolenic acid against multiple sublethal doses of x-irradiation in the rat. | 1955 | J. Nutr. | pmid:14368364 |
pmid:14318462 | ||||
WARAVDEKAR VS et al. | HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. | 1964 | Am. J. Pathol. | pmid:14234476 |
RAHM JJ and HOLMAN RT | EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. | 1964 | J. Nutr. | pmid:14210015 |
pmid:14201664 | ||||
KORN ED and GREENBLATT CL | SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. | 1963 | Science | pmid:14074842 |
MOHRHAUER H and HOLMAN RT | EFFECT OF LINOLENIC ACID UPON THE METABOLISM OF LINOLEIC ACID. | 1963 | J. Nutr. | pmid:14061405 |
JORDAN GL et al. | The effect of linoleic and linolenic acid, estradiol valerate and beta sitosterol upon experimentally induced hypercholesterolemia and the development of lipid changes in the aorta of dogs. | 1961 | Am. J. Med. Sci. | pmid:13790676 |
Schempp H et al. | Antioxidative properties of Iberis amara extracts in biochemical model reactions. | 2003 | Arzneimittelforschung | pmid:13677247 |
pmid:13642132 | ||||
Noguchi A et al. | Effects of casein and soy-protein on alpha-linolenic acid metabolism in rats. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1363922 |
Seppänen-Laakso T et al. | Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. | 1992 | Br. J. Nutr. | pmid:1362891 |
Hoffman DR and Uauy R | Essentiality of dietary omega 3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. | 1992 | Lipids | pmid:1362792 |
Rabinovitch-Chable H et al. | Purification of lipoxygenase and hydroperoxide dehydrase in flaxseeds: interaction between these enzymatic activities. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1359887 |
Sakai K et al. | Lipid lowering effects of high linoleate and high alpha-linolenate diets in rats and mice. Consequence of long-term feedings. | 1992 | Chem. Pharm. Bull. | pmid:1358471 |
Sim JS et al. | Alpha-linolenic acid metabolism: the chicken and the egg. | 1992 May-Jun | Nutrition | pmid:1356037 |
Dick TA and Yang X | Alpha-linolenic acid metabolism in fish. | 1992 May-Jun | Nutrition | pmid:1356036 |
Kelley DS | Alpha-linolenic acid and immune response. | 1992 May-Jun | Nutrition | pmid:1356035 |
Emken EA et al. | Human metabolic studies with deuterated alpha-linolenic acid. | 1992 May-Jun | Nutrition | pmid:1356034 |
Boudreau MD et al. | Alpha-linolenic acid and prostaglandin synthesis. | 1992 May-Jun | Nutrition | pmid:1356033 |
Garg ML and Clandinin MT | Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. | 1992 May-Jun | Nutrition | pmid:1356032 |
Roth HP and Kirchgessner M | [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. | 1992 | Ann. Nutr. Metab. | pmid:1354951 |
Simopoulos AP et al. | Common purslane: a source of omega-3 fatty acids and antioxidants. | 1992 | J Am Coll Nutr | pmid:1354675 |
Fayard JM et al. | Dietary alpha-linolenic acid deficiency and early uterine development in female rats. | 1992 | J. Nutr. | pmid:1352346 |
Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
Alsted AL and Høy CE | Fatty acid profiles of brain phospholipid subclasses of rats fed n - 3 polyunsaturated fatty acids of marine or vegetable origin. A two generation study. | 1992 | Biochim. Biophys. Acta | pmid:1350736 |
Holub BJ and Celi B | Relationships of alpha-linolenic acid to platelet fatty acid composition and trans content of cholesterol-free foods. | 1992 Mar-Apr | Nutrition | pmid:1350475 |
Singer P | Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. | 1992 Mar-Apr | Nutrition | pmid:1350474 |
Bjerve KS et al. | Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. | 1992 Mar-Apr | Nutrition | pmid:1350473 |
Arbuckle LD and Innis SM | Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. | 1992 | Lipids | pmid:1349717 |
FISHER H and LEVEILLE GA | Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. | 1957 | J. Nutr. | pmid:13476240 |
Bourre JM et al. | Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. | 1992 | Biochim. Biophys. Acta | pmid:1347458 |
Yamazaki K et al. | Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. | 1992 | Biochim. Biophys. Acta | pmid:1346092 |
Cunnane S | Cholesterol lowering by alpha-linolenic acid. | 1992 | Am. J. Clin. Nutr. | pmid:1345883 |
STEINBERG G et al. | Metabolism of essential fatty acids. V. Metabolic pathway of linolenic acid. | 1957 | J. Biol. Chem. | pmid:13405913 |
pmid:13272072 | ||||
Langelier B et al. | Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. | 2003 | J. Neurosci. Res. | pmid:13130515 |
Schmelz EA et al. | Nitrogen deficiency increases volicitin-induced volatile emission, jasmonic acid accumulation, and ethylene sensitivity in maize. | 2003 | Plant Physiol. | pmid:12970495 |
Morel C et al. | Isoflavones as potentiators of antibacterial activity. | 2003 | J. Agric. Food Chem. | pmid:12952418 |
Lang-Lazdunski L et al. | Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. | 2003 | J. Vasc. Surg. | pmid:12947278 |
Dewhurst RJ et al. | Comparison of grass and legume silages for milk production. 2. In vivo and in sacco evaluations of rumen function. | 2003 | J. Dairy Sci. | pmid:12939085 |
Looking for the number-one omega-3. All three varieties are probably good for you, but evidence for the EPA and DHA in fish is the strongest. | 2003 | Harv Health Lett | pmid:12936877 | |
Li Y et al. | Impact of dietary n-3 FA deficiency on rat bone tissue FA composition. | 2003 | Lipids | pmid:12934680 |
Glocker TM | [Pathology of placenta of rats induced by fatty acid deficiency]. | 2000 | Rev Fac Cien Med Univ Nac Cordoba | pmid:12934235 |
Kouba M et al. | Effect of a high-linolenic acid diet on lipogenic enzyme activities, fatty acid composition, and meat quality in the growing pig. | 2003 | J. Anim. Sci. | pmid:12926779 |
Damiani E et al. | Comparison of antioxidant activity between aromatic indolinonic nitroxides and natural and synthetic antioxidants. | 2003 | Free Radic. Res. | pmid:12911269 |
Burdge GC et al. | Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. | 2003 | Br. J. Nutr. | pmid:12908891 |
Trommer H et al. | Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. | 2003 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:12907834 |
Ravindra PV and Narayan MS | Antioxidant activity of the anthocyanin from carrot (Daucus carota) callus culture. | 2003 | Int J Food Sci Nutr | pmid:12907406 |
Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907139 |
Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
Miyazawa D et al. | Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. | 2003 | Life Sci. | pmid:12899931 |
Mulder C et al. | Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease. | 2003 | J Neural Transm | pmid:12898349 |
Ratnayake WM and Gilani GS | Protective effects of flax meal against hypercholesterolemia and hypertriglyceridemia in rats. | 2003 | J Am Coll Nutr | pmid:12897048 |
Daligault F et al. | Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris. | 2003 | Phytochemistry | pmid:12877913 |
Gavino VC et al. | Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria. | 2003 | Lipids | pmid:12848298 |
Hosokawa M et al. | Production of novel tetrahydroxyfuranyl fatty acids from alpha-linolenic acid by Clavibacter sp. strain ALA2. | 2003 | Appl. Environ. Microbiol. | pmid:12839755 |
Mori N et al. | Identification of volicitin-related compounds from the regurgitant of lepidopteran caterpillars. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834303 |