Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Wang L et al. | Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. | 2008 | Chem. Biol. Interact. | pmid:18155686 |
Saha SS and Ghosh M | Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model. | 2011 | Chem. Biol. Interact. | pmid:21382362 |
Sakai K and Okuyama H | Effects of a high alpha-linolenate and high linoleate diet on hemolysis and lipid peroxidation of rat erythrocytes. | 1991 | Chem. Pharm. Bull. | pmid:1682062 |
Sakai K et al. | Lipid lowering effects of high linoleate and high alpha-linolenate diets in rats and mice. Consequence of long-term feedings. | 1992 | Chem. Pharm. Bull. | pmid:1358471 |
Kuklev DV and Smith WL | Synthesis of four isomers of parinaric acid. | 2004 | Chem. Phys. Lipids | pmid:15351273 |
Onyango AN et al. | The rapid oxidative degradation of a phosphatidylcholine bearing an oxidatively modified acyl chain with a 2,4-dienal terminal. | 2004 | Chem. Phys. Lipids | pmid:15210367 |
Loreau O et al. | Large-scale preparation of (9Z,12E)-[1-(13)C]-octadeca-9,12-dienoic acid, (9Z,12Z,15E)-[1-(13)C]-octadeca-9,12,15-trienoic acid and their [1-(13)C] all-cis isomers. | 2000 | Chem. Phys. Lipids | pmid:10878236 |
Grechkin AN et al. | Thermal conversions of trimethylsilyl peroxides of linoleic and linolenic acids. | 2005 | Chem. Phys. Lipids | pmid:16242681 |
Iacazio G | Easy access to various natural keto polyunsaturated fatty acids and their corresponding racemic alcohols. | 2003 | Chem. Phys. Lipids | pmid:14499470 |
Cui PH et al. | Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. | 2008 | Chem. Phys. Lipids | pmid:18339314 |
Ueno S et al. | Polymorphism of linoleic acid (cis-9, cis-12-octadecadienoic acid) and alpha-linolenic acid (cis-9, cis-12, cis-15-octadecatrienoic acid). | 2000 | Chem. Phys. Lipids | pmid:11090846 |
Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |
Aou S et al. | Green odor reduces pain sensation and fatigue-like responses without affecting sensorimotor function. | 2005 | Chem. Senses | pmid:15738147 |
Yasui Y et al. | Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. | 2006 | Chemotherapy | pmid:16899971 |
Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
Bryan RM et al. | Starring TREK-1: the next generation of vascular K+ channels. | 2007 | Circ. Res. | pmid:17641234 |
Georgiadi A et al. | Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. | 2010 | Circ. Res. | pmid:20378851 |
Blondeau N et al. | Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. | 2007 | Circ. Res. | pmid:17556656 |
Henry MM et al. | Effect of dietary alpha-linolenic acid on equine monocyte procoagulant activity and eicosanoid synthesis. | 1990 | Circ. Shock | pmid:1979759 |
Tavani A et al. | Alpha-linolenic acid and nonfatal acute myocardial infarction. | 2003 | Circulation | pmid:14581393 |
Billman GE et al. | Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. | 1999 | Circulation | pmid:10318669 |
Baylin A et al. | Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. | 2003 | Circulation | pmid:12668490 |
Mozaffarian D et al. | Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. | 2005 | Circulation | pmid:15630029 |
Harris WS | Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify? | 2008 | Circulation | pmid:18606912 |
Campos H et al. | Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. | 2008 | Circulation | pmid:18606916 |
Hauswirth CB et al. | High omega-3 fatty acid content in alpine cheese: the basis for an alpine paradox. | 2004 | Circulation | pmid:14676141 |
Ros E et al. | A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. | 2004 | Circulation | pmid:15037535 |
Leaf A | Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. | 1999 | Circulation | pmid:9989956 |
Kris-Etherton PM et al. | Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. | 2002 | Circulation | pmid:12438303 |
Albert CM et al. | Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. | 2005 | Circulation | pmid:16301356 |
Harris WS | Alpha-linolenic acid: a gift from the land? | 2005 | Circulation | pmid:15939831 |
Robertson RM and Smaha L | Can a Mediterranean-style diet reduce heart disease? | 2001 | Circulation | pmid:11282917 |
Kris-Etherton P et al. | AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. | 2001 | Circulation | pmid:11282918 |
de Lorgeril M and Salen P | The Mediterranean diet in secondary prevention of coronary heart disease. | 2006 | Clin Invest Med | pmid:17058434 |
Hoogeveen EK et al. | Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. | 2014 | Clin J Am Soc Nephrol | pmid:25104273 |
Pomponi M and Pomponi M | DHA deficiency and Alzheimer's disease. | 2008 | Clin Nutr | pmid:18037538 |
Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
Moltó-Puigmartà C et al. | Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants. | 2011 | Clin Nutr | pmid:20800325 |
Moltó-Puigmartà C et al. | Additional data from our study on fatty acids variations during lactation: correlations between n-3 and n-6 PUFAs in human colostrum, transitional, and mature milk. | 2011 | Clin Nutr | pmid:21470725 |
Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
Caspar-Bauguil S et al. | Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. | 2012 | Clin Nutr | pmid:22385730 |
Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
Menéndez JA et al. | HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". | 2006 | Clin Transl Oncol | pmid:17134970 |
Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
Utsunomiya T et al. | Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. | 2000 | Clin. Cancer Res. | pmid:11156258 |
Kumar KV et al. | Oxidant stress and essential fatty acids in patients with risk and established ARDS. | 2000 | Clin. Chim. Acta | pmid:10876008 |
McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
Laitinen K et al. | Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. | 2006 | Clin. Exp. Allergy | pmid:16433853 |
Calder PC | Abnormal fatty acid profiles occur in atopic dermatitis but what do they mean? | 2006 | Clin. Exp. Allergy | pmid:16433850 |
Simon MC et al. | Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes. | 2013 | Clin. Exp. Immunol. | pmid:23600826 |
Harbige LS et al. | The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production. | 2000 | Clin. Exp. Immunol. | pmid:11122253 |
Matsunaga H et al. | Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescence accelerated mice (SAM)P1/Yit mice model. | 2009 | Clin. Exp. Immunol. | pmid:19793338 |
Tomioka H et al. | Effector molecules of the host defence mechanism against Mycobacterium avium complex: the evidence showing that reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids each alone are not decisive in expression of macrophage antimicrobial activity against the parasites. | 1997 | Clin. Exp. Immunol. | pmid:9276519 |
Dusting GJ et al. | Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats. | 1981 Sep-Oct | Clin. Exp. Pharmacol. Physiol. | pmid:6276057 |
Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
Poureslami R et al. | Effect of dietary fat source on the deposition of n-3 polyunsaturated fatty acids in broilers: a whole balance approach. | 2007 | Commun. Agric. Appl. Biol. Sci. | pmid:18018899 |
Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Soppela P and Nieminen M | The effect of wintertime undernutrition on the fatty acid composition of leg bone marrow fats in reindeer (Rangifer tarandus tarandus L.). | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163305 |
Tu WC et al. | Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23085323 |
Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
Ihara M et al. | Comparative effects of short- and long-term feeding of safflower oil and perilla oil on lipid metabolism in rats. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9972297 |
Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
Ganga R et al. | Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16257554 |
Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
Kanazawa A et al. | Relationship between essential fatty acid requirements of aquatic animals and the capacity for bioconversion of linolenic acid to highly unsaturated fatty acids. | 1979 | Comp. Biochem. Physiol., B | pmid:233802 |
Ihara-Watanabe M et al. | Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10327618 |
Meinelt T et al. | Correlation of diets high in n-6 polyunsaturated fatty acids with high growth rate in zebrafish (Danio rerio). | 2000 | Comp. Med. | pmid:10987667 |
Leyva DR et al. | The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled trial. | 2011 | Contemp Clin Trials | pmid:21616170 |
Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
Singh KK et al. | Flaxseed: a potential source of food, feed and fiber. | 2011 | Crit Rev Food Sci Nutr | pmid:21390942 |
Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
Pratt VC et al. | Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans. | 2002 | Crit. Care Med. | pmid:12163788 |
Renaud S and Lanzmann-Petithory D | Dietary fats and coronary heart disease pathogenesis. | 2002 | Curr Atheroscler Rep | pmid:12361488 |
von Schacky C | The role of omega-3 fatty acids in cardiovascular disease. | 2003 | Curr Atheroscler Rep | pmid:12573200 |
Geleijnse JM et al. | Alpha-linolenic acid: is it essential to cardiovascular health? | 2010 | Curr Atheroscler Rep | pmid:20814766 |
Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
Burdge G | Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. | 2004 | Curr Opin Clin Nutr Metab Care | pmid:15075703 |
Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
Brenna JT | Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844977 |
Xian M et al. | Production of linolenic acid by Mortierella isabellina grown on octadecanol. | 2002 | Curr. Microbiol. | pmid:11815860 |
Mensink R | Essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925181 |
Mutanen M and Freese R | Polyunsaturated fatty acids and platelet aggregation. | 1996 | Curr. Opin. Lipidol. | pmid:8925182 |
Sugano M and Ikeda I | Metabolic interactions between essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925188 |
Nelson TL et al. | Inflammatory markers are not altered by an eight week dietary alpha-linolenic acid intervention in healthy abdominally obese adult males and females. | 2007 | Cytokine | pmid:17613244 |
Nelson TL and Hickey MS | Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. | 2004 | Cytokine | pmid:15157896 |
Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
Jones DB et al. | Glucose, insulin and platelet fatty acids following myocardial infarction: an association with infarct size. | 1987 Jul-Aug | Diabete Metab | pmid:3315767 |
Bajaj M et al. | Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. | 2005 | Diabetes | pmid:16249438 |
Demizieux L et al. | Early Low-Fat Diet Enriched With Linolenic Acid Reduces Liver Endocannabinoid Tone and Improves Late Glycemic Control After a High-Fat Diet Challenge in Mice. | 2016 | Diabetes | pmid:27207550 |
Khokher MA and Dandona P | The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. | 1988 | Diabetes Res. | pmid:2906578 |
Flachs P et al. | Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. | 2005 | Diabetologia | pmid:16205884 |
Zhao A et al. | Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 | DNA Cell Biol. | pmid:15307955 |
Kozachenko AI et al. | Characteristics of beta-carotene-induced inhibition of free radical oxidation of fatty acids with different degree of unsaturation. | 2001 Jul-Aug | Dokl. Biochem. Biophys. | pmid:11665681 |
Coyral-Castel S et al. | Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. | 2010 | Domest. Anim. Endocrinol. | pmid:20097509 |
Ben-Shabat S et al. | Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. | 2007 | Drug Dev Ind Pharm | pmid:18058312 |
Giovannini M et al. | The role of dietary polyunsaturated fatty acids during the first 2 years of life. | 1998 | Early Hum. Dev. | pmid:10102658 |
Pankiewicz E et al. | Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section. | 2007 | Early Hum. Dev. | pmid:17059872 |
Lauritzen I et al. | Polyunsaturated fatty acids are potent neuroprotectors. | 2000 | EMBO J. | pmid:10775263 |
Kapich AN et al. | Comparative evaluation of manganese peroxidase- and Mn(III)-initiated peroxidation of C18 unsaturated fatty acids by different methods. | 2011 | Enzyme Microb. Technol. | pmid:22112267 |