Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
Lapenna D et al. | Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. | 1994 | Free Radic. Res. | pmid:7912612 |
Hardwick SJ et al. | Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate. | 1997 | Free Radic. Res. | pmid:9167940 |
Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
Damiani E et al. | Comparison of antioxidant activity between aromatic indolinonic nitroxides and natural and synthetic antioxidants. | 2003 | Free Radic. Res. | pmid:12911269 |
Barden A et al. | The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. | 2011 | Free Radic. Res. | pmid:21235285 |
Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
Yan S et al. | Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. | 2015 | Fungal Genet. Biol. | pmid:25498164 |
Trimarco B et al. | [The Alpha Omega study]. | 2011 Jul-Aug | G Ital Cardiol (Rome) | pmid:21779112 |
Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
Reinprecht Y et al. | Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean (Glycine max (L.) Merrill) germplasm. | 2006 | Genome | pmid:17426766 |
Ghamkhar K et al. | Camelina (Camelina sativa (L.) Crantz) as an alternative oilseed: molecular and ecogeographic analyses. | 2010 | Genome | pmid:20616877 |
Banik M et al. | Transcript profiling and gene characterization of three fatty acid desaturase genes in high, moderate, and low linolenic acid genotypes of flax (Linum usitatissimum L.) and their role in linolenic acid accumulation. | 2011 | Genome | pmid:21627464 |
Why not flaxseed oil? There's no mercury to worry about, and it does contain omega-3 fats...but not the best kind. | 2006 | Harv Health Lett | pmid:17152637 | |
Looking for the number-one omega-3. All three varieties are probably good for you, but evidence for the EPA and DHA in fish is the strongest. | 2003 | Harv Health Lett | pmid:12936877 | |
Mason JE | By the way, doctor. I am confused about omega-3 fats Are the different types equally good for you? | 2010 | Harv Health Lett | pmid:20821857 |
Hosmer C | Ask the doctor. Are the omega-3 fats in flaxseed oil as good for the heart as those in fish or fish oil? Do they have the same side effects? The American Heart Association warns about getting more than 3 grams of omega-3 fats a day without a doctor's supervision, but one teaspoon of my concentrated flaxseed oil--the recommended dose--contains 6.2 grams. Should I be worried? | 2005 | Harv Heart Lett | pmid:16363041 |
Flaxseed oil: healthful or harmful for men? | 2003 | Harv Mens Health Watch | pmid:14505958 | |
Good for the heart but not for the prostate? The alpha-linolenic acid dilemma. | 2002 | Harv Mens Health Watch | pmid:11823168 | |
Omega-3 fatty acids in the treatment of depression. | 2001 | Harv Ment Health Lett | pmid:11770480 | |
Wendland E et al. | Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. | 2006 | Heart | pmid:15890766 |
Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
Jhala AJ et al. | Pollen-mediated gene flow in flax (Linum usitatissimum L.): can genetically engineered and organic flax coexist? | 2011 | Heredity (Edinb) | pmid:20551976 |
Tsubura A et al. | Role of fatty acids in malignancy and visual impairment: epidemiological evidence and experimental studies. | 2009 | Histol. Histopathol. | pmid:19085838 |
Numata M | [Antitumor effects of alpha-linolenic acid on the human tumor transplanted in nude mice and on the metastasis of Vx-7 tumor in rabbit]. | 1995 | Hokkaido Igaku Zasshi | pmid:7744366 |
Wang S et al. | Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. | 2008 | Hypertens. Res. | pmid:18633173 |
Begg DP et al. | Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. | 2010 | Hypertens. Res. | pmid:20520615 |
Djoussé L et al. | Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure. | 2006 | Hypertension | pmid:16801477 |
Rodriguez-Leyva D et al. | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | 2013 | Hypertension | pmid:24126178 |
Caligiuri SP et al. | Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an α-linolenic acid-induced inhibition of soluble epoxide hydrolase. | 2014 | Hypertension | pmid:24777981 |
Ueshima H et al. | Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. | 2007 | Hypertension | pmid:17548718 |
Maillard V et al. | Interaction of dietary beta-carotene and alpha-linolenic acid: effect on promotion of experimental mammary tumours. | 2002 | IARC Sci. Publ. | pmid:12484221 |
Bazinet RP et al. | Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant. | 2004 | Immunol. Lett. | pmid:15325802 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Sengupta A and Ghosh M | Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. | 2013 | Indian J. Exp. Biol. | pmid:23678545 |
Singh S et al. | Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid. | 2008 | Indian J. Exp. Biol. | pmid:18697604 |
Singh S et al. | Antibacterial activity of Ocimum sanctum L. fixed oil. | 2005 | Indian J. Exp. Biol. | pmid:16187537 |
Kiyota R et al. | Biosynthetic pathways of the sex pheromone components and substrate selectivity of the oxidation enzymes working in pheromone glands of the fall webworm, Hyphantria cunea. | 2011 | Insect Biochem. Mol. Biol. | pmid:21338674 |
Yoshinaga N et al. | In vitro biosynthesis of volicitin in Spodoptera litura. | 2005 | Insect Biochem. Mol. Biol. | pmid:15681227 |
Kuhns EH et al. | A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. | 2012 | Insect Biochem. Mol. Biol. | pmid:22056272 |
Ding BJ et al. | Terminal fatty-acyl-CoA desaturase involved in sex pheromone biosynthesis in the winter moth (Operophtera brumata). | 2011 | Insect Biochem. Mol. Biol. | pmid:21651981 |
DeFilippis AP et al. | Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid. | 2009 | Int J Food Sci Nutr | pmid:19468954 |
Peng CC et al. | Aqua-culture improved buckwheat sprouts with more abundant precious nutrients and hypolipidemic activity. | 2009 | Int J Food Sci Nutr | pmid:19568972 |
Ravindra PV and Narayan MS | Antioxidant activity of the anthocyanin from carrot (Daucus carota) callus culture. | 2003 | Int J Food Sci Nutr | pmid:12907406 |
Metwal N et al. | Influence of debittered, defatted fenugreek seed powder and flaxseed powder on the rheological characteristics of dough and quality of cookies. | 2011 | Int J Food Sci Nutr | pmid:21250900 |
Glew RS and Vanderjagt D | Coping strategies and nutritional health in rural Niger: recommendations for consumption of wild plant foods in the Sahel. | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135022 |
Ovesen L et al. | The effect of microwave heating on vitamins B1 and E, and linoleic and linolenic acids, and immunoglobulins in human milk. | 1996 | Int J Food Sci Nutr | pmid:8889628 |
Garsetti M et al. | Fat composition of vegetable oil spreads and margarines in the USA in 2013: a national marketplace analysis. | 2016 | Int J Food Sci Nutr | pmid:27046021 |
Carotenuto F et al. | Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies. | 2016 | Int J Med Sci | pmid:26941581 |
Esquivel-Hernández DA et al. | Supercritical Carbon Dioxide and Microwave-Assisted Extraction of Functional Lipophilic Compounds from Arthrospira platensis. | 2016 | Int J Mol Sci | pmid:27164081 |
Wang JJ et al. | Two ω-3 FADs Are Associated with Peach Fruit Volatile Formation. | 2016 | Int J Mol Sci | pmid:27043529 |
Hibi M et al. | Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women. | 2008 | Int J Obes (Lond) | pmid:18936764 |
Bhatia KS and Singh J | Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis. | 1999 | Int J Pharm | pmid:10370194 |
Sekine S et al. | Alpha-linolenic acid-rich flaxseed oil ingestion increases plasma adiponectin level in rats. | 2008 Jul-Sep | Int J Vitam Nutr Res | pmid:19326346 |
Li D et al. | Alpha-linolenic acid content of commonly available nuts in Hangzhou. | 2006 | Int J Vitam Nutr Res | pmid:16711652 |
Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
Suzuki H et al. | Long-term effect of a trace amount of tea catechins with perilla oil on the plasma lipids in mice. | 1998 | Int J Vitam Nutr Res | pmid:9706503 |
Gerster H | Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? | 1998 | Int J Vitam Nutr Res | pmid:9637947 |
Oriani G et al. | Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver. | 1999 | Int J Vitam Nutr Res | pmid:10642895 |
Pereira C et al. | The alpha-linolenic acid content of green vegetables commonly available in Australia. | 2001 | Int J Vitam Nutr Res | pmid:11582857 |
Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
Dokko RC et al. | Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. | 1998 | Int. J. Biochem. Cell Biol. | pmid:9597754 |
Marmunti M and Catalá A | Incorporation of 1-(14)C linoleic acid in rat liver nuclei and chromatin fractions. | 2001 | Int. J. Biochem. Cell Biol. | pmid:11311857 |
Colombo C et al. | Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial. | 2005 Jul-Sep | Int. J. Biol. Markers | pmid:16240844 |
Sun L et al. | The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. | 2013 | Int. J. Biol. Sci. | pmid:23983614 |
Zhang L et al. | Quantitative genomics of 30 complex phenotypes in Wagyu x Angus Fâ‚ progeny. | 2012 | Int. J. Biol. Sci. | pmid:22745575 |
Sun L et al. | Coccomyxa Gloeobotrydiformis Improves Learning and Memory in Intrinsic Aging Rats. | 2015 | Int. J. Biol. Sci. | pmid:26078724 |
Giovannucci E et al. | Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. | 2007 | Int. J. Cancer | pmid:17450530 |
Thiébaut AC et al. | Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. | 2009 | Int. J. Cancer | pmid:19035453 |
Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
De Stefani E et al. | Essential fatty acids and breast cancer: a case-control study in Uruguay. | 1998 | Int. J. Cancer | pmid:9590123 |
Almendingen K et al. | Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. | 2007 | Int. J. Cancer | pmid:17096349 |
Ulas T et al. | Does α-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients? | 2013 | Int. J. Cardiol. | pmid:23200266 |
Yan W et al. | Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas. | 2013 | Int. J. Cardiol. | pmid:23313466 |
Yan W et al. | Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. | 2013 | Int. J. Cardiol. | pmid:23102606 |
He F et al. | Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring. | 2014 | Int. J. Dev. Neurosci. | pmid:24866706 |
Niculescu MD et al. | Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. | 2011 | Int. J. Dev. Neurosci. | pmid:21964326 |
Sado-Kamdem SL et al. | Effect of alpha-linolenic, capric and lauric acid on the fatty acid biosynthesis in Staphylococcus aureus. | 2009 | Int. J. Food Microbiol. | pmid:19168249 |
Sado Kamdem S et al. | Effect of capric, lauric and alpha-linolenic acids on the division time distributions of single cells of Staphylococcus aureus. | 2008 | Int. J. Food Microbiol. | pmid:18793815 |
Gorissen L et al. | Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. | 2012 | Int. J. Food Microbiol. | pmid:22405353 |
Kawano Y and Noma T | Inhibition by lecithin-bound iodine (LBI) of inducible allergen-specific T lymphocytes' responses in allergic diseases. | 1996 | Int. J. Immunopharmacol. | pmid:8894803 |
Andoh A et al. | N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. | 2003 | Int. J. Mol. Med. | pmid:14533000 |
Masuelli L et al. | Intercalated disk remodeling in delta-sarcoglycan-deficient hamsters fed with an alpha-linolenic acid-enriched diet. | 2008 | Int. J. Mol. Med. | pmid:18097614 |
Zhang H et al. | A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. | 2012 | Int. J. Mol. Med. | pmid:22692672 |
Hatakeyama Y and Scarpace PJ | Transcriptional regulation of uncoupling protein-2 gene expression in L6 myotubes. | 2001 | Int. J. Obes. Relat. Metab. Disord. | pmid:11753581 |
Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
Jeffrey BG et al. | n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147619 |
Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
Erdinest N et al. | Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22669722 |
Edwards R et al. | Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. | 1998 | J Affect Disord | pmid:9543204 |
Nieman DC et al. | Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. | 2012 | J Altern Complement Med | pmid:22830971 |
Almario RU and Karakas SE | Lignan content of the flaxseed influences its biological effects in healthy men and women. | 2013 | J Am Coll Nutr | pmid:23885993 |
Bloedon LT et al. | Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. | 2008 | J Am Coll Nutr | pmid:18460483 |
Austria JA et al. | Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed. | 2008 | J Am Coll Nutr | pmid:18689552 |
Spence JD et al. | The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress. | 2003 | J Am Coll Nutr | pmid:14684754 |
Ratnayake WM and Gilani GS | Protective effects of flax meal against hypercholesterolemia and hypertriglyceridemia in rats. | 2003 | J Am Coll Nutr | pmid:12897048 |
West SG et al. | Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. | 2010 | J Am Coll Nutr | pmid:21677123 |