alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
| Coyral-Castel S et al. | Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. | 2010 | Domest. Anim. Endocrinol. | pmid:20097509 |
| Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
| Sartorelli DS et al. | Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians. | 2010 | Nutrition | pmid:19647413 |
| Even P et al. | Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. | 2010 | Metab. Clin. Exp. | pmid:19775712 |
| Huang CB and Ebersole JL | A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives. | 2010 | Mol Oral Microbiol | pmid:20331795 |
| Joffe YT et al. | Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women. | 2010 | J. Nutr. | pmid:20335630 |
| Cornish SM and Chilibeck PD | Multiple interventions for treating chronic inflammation in older adults: what is the best strategy? | 2010 | Exerc Sport Sci Rev | pmid:20335742 |
| Khas-Erdene Q et al. | Short communication: responses to increasing amounts of free alpha-linolenic acid infused into the duodenum of lactating dairy cows. | 2010 | J. Dairy Sci. | pmid:20338445 |
| Namiranian K et al. | Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20357027 |
| Adkins Y and Kelley DS | Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. | 2010 | J. Nutr. Biochem. | pmid:20382009 |
| Field CJ et al. | Effect of feeding a formula supplemented with long-chain polyunsaturated fatty acids for 14 weeks improves the ex vivo response to a mitogen and reduces the response to a soy protein in infants at low risk for allergy. | 2010 | J. Pediatr. Gastroenterol. Nutr. | pmid:20386325 |
| Gracious BL et al. | Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. | 2010 | Bipolar Disord | pmid:20402707 |
| Wall R et al. | Impact of administered bifidobacterium on murine host fatty acid composition. | 2010 | Lipids | pmid:20405232 |
| Mazer LM et al. | Docosahexaenoic acid status in females of reproductive age with maple syrup urine disease. | 2010 | J. Inherit. Metab. Dis. | pmid:20217236 |
| Carayol M et al. | Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. | 2010 | Cancer Causes Control | pmid:19921446 |
| Ander BP et al. | Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet. | 2010 | Metab. Clin. Exp. | pmid:19913851 |
| Legrand P et al. | The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans. | 2010 | Lipids | pmid:20012223 |
| Zhu H et al. | Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. | 2010 | J. Nutr. Biochem. | pmid:19954955 |
| Christensen KB et al. | Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.). | 2010 | J Ethnopharmacol | pmid:20696231 |
| Burns RN and Moniri NH | Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20471368 |
| Harauma A et al. | Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition. | 2010 | Lipids | pmid:20625936 |
| Shannon J et al. | Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20630734 |
| Wang S et al. | Temperature dependence of autoxidation of perilla oil and tocopherol degradation. | 2010 | J. Food Sci. | pmid:20722903 |
| Ghamkhar K et al. | Camelina (Camelina sativa (L.) Crantz) as an alternative oilseed: molecular and ecogeographic analyses. | 2010 | Genome | pmid:20616877 |
| Hassan A et al. | An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis. | 2010 | J. Nutr. | pmid:20724486 |
| Oya J et al. | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Eur J Clin Nutr | pmid:20683463 |
| Taylor CG et al. | Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. | 2010 | J Am Coll Nutr | pmid:20595648 |
| Naqvi AZ et al. | n-3 fatty acids and periodontitis in US adults. | 2010 | J Am Diet Assoc | pmid:21034880 |
| Begg DP et al. | Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. | 2010 | Hypertens. Res. | pmid:20520615 |
| Szalai G et al. | Effect of nitrogen source in the fertilizing solution on nutritional quality of three members of the Portulaca oleracea aggregate. | 2010 | J. Sci. Food Agric. | pmid:20572061 |
| Broughton KS et al. | High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. | 2010 | Nutr Res | pmid:21056289 |
| Seltmann MA et al. | Jasmonates during senescence: signals or products of metabolism? | 2010 | Plant Signal Behav | pmid:21057217 |
| Brand A et al. | Retailoring docosahexaenoic acid-containing phospholipid species during impaired neurogenesis following omega-3 alpha-linolenic acid deprivation. | 2010 | J. Neurochem. | pmid:20557429 |
| Lin YH et al. | Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. | 2010 | Am. J. Clin. Nutr. | pmid:20534748 |
| Muller-Delp JM | The role of TREK-1 in cerebrovascular regulation remains elusive: focus on "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20484697 |
| Degirolamo C et al. | Dietary n-3 LCPUFA from fish oil but not alpha-linolenic acid-derived LCPUFA confers atheroprotection in mice. | 2010 | J. Lipid Res. | pmid:20154006 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Seo PJ et al. | Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity. | 2010 | Biochem. J. | pmid:20156199 |
| Rajwade AV et al. | Relatedness of Indian flax genotypes (Linum usitatissimum L.): an inter-simple sequence repeat (ISSR) primer assay. | 2010 | Mol. Biotechnol. | pmid:20195799 |
| Zhou J et al. | Trans-membrane uptake and intracellular metabolism of fatty acids in Atlantic salmon (Salmo salar L.) hepatocytes. | 2010 | Lipids | pmid:20186497 |
| Liu Q et al. | Influence of linolenic acid content on the oxidation of milk fat. | 2010 | J. Agric. Food Chem. | pmid:20175540 |
| Bharadwaj AS et al. | Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. | 2010 | Lipids | pmid:20049582 |
| Eckert GP et al. | Plant derived omega-3-fatty acids protect mitochondrial function in the brain. | 2010 | Pharmacol. Res. | pmid:20079842 |
| Nguemeni C et al. | Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. | 2010 | Pharmacol. Res. | pmid:20036742 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Ruiz-Rodriguez A et al. | Recent trends in the advanced analysis of bioactive fatty acids. | 2010 | J Pharm Biomed Anal | pmid:19525080 |
| Wu TC et al. | Fatty acid composition of Taiwanese human milk. | 2010 | J Chin Med Assoc | pmid:21093826 |
| Steinritz D et al. | Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. | 2010 | Toxicol. Sci. | pmid:20833707 |
| Miyazawa D et al. | Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. | 2010 | Life Sci. | pmid:20837030 |
| Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
| Welch AA et al. | Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. | 2010 | Am. J. Clin. Nutr. | pmid:20861171 |
| Kromhout D et al. | n-3 fatty acids and cardiovascular events after myocardial infarction. | 2010 | N. Engl. J. Med. | pmid:20929341 |
| Tsukada K et al. | Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. | 2010 | Phytochemistry | pmid:20952041 |
| West SG et al. | Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. | 2010 | J Am Coll Nutr | pmid:21677123 |
| Kim M et al. | Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly. | 2010 | Nutr Res | pmid:21130294 |
| Georgiadi A et al. | Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. | 2010 | Circ. Res. | pmid:20378851 |
| DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
| Yoo HJ and HÃ¥kansson K | Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. | 2010 | Anal. Chem. | pmid:20704384 |
| Wan ZX et al. | Lipid content and fatty acids composition of mature human milk in rural North China. | 2010 | Br. J. Nutr. | pmid:19825220 |
| Lau BY et al. | Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. | 2010 | Appl Physiol Nutr Metab | pmid:20962915 |
| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Hurst S et al. | Dietary fatty acids and arthritis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20189789 |
| McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
| Muramatsu T et al. | Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. | 2010 May-Jun | Prev Med | pmid:20211645 |
| Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
| McNamara RK et al. | Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817496 |
| Berkov S et al. | Changes in apolar metabolites during in vitro organogenesis of Pancratium maritimum. | 2010 Oct-Nov | Plant Physiol. Biochem. | pmid:20702100 |
| Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Moltó-Puigmartà C et al. | Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants. | 2011 | Clin Nutr | pmid:20800325 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Nelson TL et al. | Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. | 2011 | Eur J Nutr | pmid:20706728 |
| Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
| Beaulieu A et al. | Leptin reverts pro-apoptotic and antiproliferative effects of α-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway. | 2011 | PLoS ONE | pmid:21991326 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Miranda J et al. | cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARα in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | 2011 | Lipids | pmid:21984112 |
| Qi J et al. | The chloroplast-localized phospholipases D α4 and α5 regulate herbivore-induced direct and indirect defenses in rice. | 2011 | Plant Physiol. | pmid:21984727 |
| Degen C et al. | Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. | 2011 | Biochim. Biophys. Acta | pmid:21889998 |
| Yalcin H et al. | Effect of γ-irradiation on bioactivity, fatty acid compositions and volatile compounds of clary sage seed (Salvia sclarea L.). | 2011 | J. Food Sci. | pmid:22417543 |
| Jung DM et al. | A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. | 2011 | J. Food Sci. | pmid:22417487 |
| Singh KK et al. | Flaxseed: a potential source of food, feed and fiber. | 2011 | Crit Rev Food Sci Nutr | pmid:21390942 |
| Barros R et al. | Dietary intake of α-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. | 2011 | Br. J. Nutr. | pmid:21443816 |
| He L et al. | Preparation of SiO2/(PMMA/Fe3O4) nanoparticles using linolenic acid as crosslink agent for nucleic acid detection using chemiluminescent method. | 2011 | J Nanosci Nanotechnol | pmid:21449377 |
| Gopinath B et al. | Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. | 2011 | Am. J. Clin. Nutr. | pmid:21411616 |
| Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
| López-López I et al. | Effect of cooking on the chemical composition of low-salt, low-fat Wakame/olive oil added beef patties with special reference to fatty acid content. | 2011 | Meat Sci. | pmid:21497025 |
| Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
| Farina EK et al. | Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. | 2011 | J. Nutr. | pmid:21508210 |
| Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
| Hejazi L et al. | Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. | 2011 | Talanta | pmid:21215858 |
| Burdge GC | Polyunsaturated fatty acid intakes and α-linolenic acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:21191139 |
| Vigeolas H et al. | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants. | 2011 | Plant Physiol. | pmid:21205621 |
| Couëdelo L et al. | Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. | 2011 | Br. J. Nutr. | pmid:21080982 |
| Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
| Holy EW et al. | Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21571683 |
| Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
| Feskens EJ | The prevention of type 2 diabetes: should we recommend vegetable oils instead of fatty fish? | 2011 | Am. J. Clin. Nutr. | pmid:21733879 |
| Sakurai K et al. | Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice. | 2011 | Nephron Exp. Nephrol. | pmid:21734409 |
| Xie N et al. | α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. | 2011 | Arch. Med. Res. | pmid:21722811 |