| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
Total
4
5,8,11-eicosatrienoic acid
5,8,11-eicosatrienoic acid is a lipid of Fatty Acyls (FA) class. 5,8,11-eicosatrienoic acid is associated with abnormalities such as Pulmonary Eosinophilia. The involved functions are known as antagonists, actin polymerization, release of sequestered calcium ion into cytoplasm, Neutrophil migration, function and Chemotaxis. 5,8,11-eicosatrienoic acid often locates in Cytoplasmic matrix and Back. The associated genes with 5,8,11-eicosatrienoic acid are Homologous Gene, IMPACT gene and ALOX12 gene. The related lipids are Fatty Acids and Eicosatrienoic Acid.
Cross Reference
Introduction
To understand associated biological information of 5,8,11-eicosatrienoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 5,8,11-eicosatrienoic acid?
5,8,11-eicosatrienoic acid is suspected in Pulmonary Eosinophilia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 5,8,11-eicosatrienoic acid
PubChem Associated disorders and diseases
What pathways are associated with 5,8,11-eicosatrienoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 5,8,11-eicosatrienoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 5,8,11-eicosatrienoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 5,8,11-eicosatrienoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 5,8,11-eicosatrienoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 5,8,11-eicosatrienoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 5,8,11-eicosatrienoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kanda H et al. | Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. | 2001 | Am. J. Hypertens. | pmid:11281236 |
| Sakuradani E et al. | Production of 5,8,11-eicosatrienoic acid by a delta5 and delta6 desaturation activity-enhanced mutant derived from a delta12 desaturation activity-defective mutant of Mortierella alpina 1S-4. | 2002 | Appl. Microbiol. Biotechnol. | pmid:12436308 |
| Fokkema MR et al. | Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445496 |
| Yoshida H et al. | Beneficial effects of n-9 eicosatrienoic acid on experimental bowel lesions. | 2003 | Surg. Today | pmid:12884098 |
| MEAD JF and SLATON WH | Metabolism of essential fatty acids. III. Isolation of 5,8,11-eicosatrienoic acid from fat-deficient rats. | 1956 | J. Biol. Chem. | pmid:13319291 |
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| FULCO AJ and MEAD JF | Metabolism of essential fatty acids. VIII. Origin of 5,8,11-eicosatrienoic acid in the fat-deficient rat. | 1959 | J. Biol. Chem. | pmid:13654388 |
| Heyd VL and Eynard AR | Effects of eicosatrienoic acid (20:3 n-9, Mead's acid) on some promalignant-related properties of three human cancer cell lines. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518560 |
| Nakano N et al. | Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. | 2005 | Biochim. Biophys. Acta | pmid:16403671 |
| Coste TC et al. | Influence of pancreatic status and sex on polyunsaturated fatty acid profiles in cystic fibrosis. | 2008 | Clin. Chem. | pmid:18089657 |
| Patel P et al. | Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18292294 |
| Strijbosch RA et al. | Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications. | 2008 | Metab. Clin. Exp. | pmid:18442636 |
| Hamazaki T et al. | The depressive effects of 5,8,11-eicosatrienoic Acid (20:3n-9) on osteoblasts. | 2009 | Lipids | pmid:18941818 |
| Adkisson HD et al. | Unique fatty acid composition of normal cartilage: discovery of high levels of n-9 eicosatrienoic acid and low levels of n-6 polyunsaturated fatty acids. | 1991 | FASEB J. | pmid:2001795 |
| van Goor SA et al. | Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20022733 |
| Karaman IuK et al. | [The role of modification of fatty acid composition of erythrocyte lipids in pathogenesis of arterial hypertension]. | 2010 | Kardiologiia | pmid:20659041 |
| Astarita G et al. | Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. | 2011 | PLoS ONE | pmid:22046234 |
| Hamazaki T et al. | Inhibitory effect of 5,8,11-eicosatrienoic acid on angiogenesis. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521862 |
| Garcia MC et al. | Chain elongation of polyunsaturated fatty acids by vascular endothelial cells: studies with arachidonate analogues. | 1990 | Lipids | pmid:2345494 |