bishomo-gamma-linolenic acid

Bishomo-gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. Bishomo-gamma-linolenic acid is associated with abnormalities such as Diabetes, Obesity, Hypertensive disease, Cirrhosis and Hepatorenal Syndrome. The involved functions are known as Oxidation, Process, Metabolic Inhibition, epoxide hydrolase activity and Signal Transduction Pathways. Bishomo-gamma-linolenic acid often locates in Protoplasm, Cytoplasmic matrix, soluble, Membrane and Tissue membrane. The associated genes with bishomo-gamma-linolenic acid are P4HTM gene, IMPACT gene, arginine methyl ester, CYP gene and PTGS1 gene. The related lipids are Fatty Acids, 17-octadecynoic acid, Lipopolysaccharides, palmitoleic acid and nervonic acid. The related experimental models are Knock-out and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of bishomo-gamma-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with bishomo-gamma-linolenic acid?

bishomo-gamma-linolenic acid is suspected in Hypertensive disease, Renal tubular disorder, Diabetes, Renal glomerular disease, Obesity, endothelial dysfunction and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with bishomo-gamma-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Neoplasms D008113 8 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with bishomo-gamma-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with bishomo-gamma-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with bishomo-gamma-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with bishomo-gamma-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with bishomo-gamma-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with bishomo-gamma-linolenic acid?

Mouse Model

Mouse Model are used in the study 'Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.' (Park F et al., 2009) and Mouse Model are used in the study 'Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.' (Liu X et al., 2008).

Knock-out

Knock-out are used in the study 'P-450 metabolites of arachidonic acid in the control of cardiovascular function.' (Roman RJ, 2002).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with bishomo-gamma-linolenic acid

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Authors Title Published Journal PubMed Link
Bihzad SM and Yousif MH 11,12-Epoxyeicosatrienoic acid induces vasodilator response in the rat perfused mesenteric vasculature. 2017 Auton Autacoid Pharmacol pmid:28332266
Yang L et al. Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers. 2017 Chest pmid:27884766
Sporková A et al. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. 2017 Physiol Res pmid:27782740
Prasinou P et al. Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. 2017 Biochim Biophys Acta Biomembr pmid:28688796
Singh SP et al. PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid. 2016 Prostaglandins Other Lipid Mediat. pmid:27418542
Wang B et al. CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1. 2016 Aging Cell pmid:27416746
Wells MA et al. Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis. 2016 Prostaglandins Other Lipid Mediat. pmid:27401401
Qin J et al. Sexually dimorphic adaptation of cardiac function: roles of epoxyeicosatrienoic acid and peroxisome proliferator-activated receptors. 2016 Physiol Rep pmid:27354541
Sporková A et al. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. 2016 Am. J. Med. Sci. pmid:27140711
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385