DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Hydroa Vacciniforme D006837 1 associated lipids
Communication Disorders D003147 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Lordosis D008141 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
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Kuipers RS et al. Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA). 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21561751
Williard DE et al. Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324227
Martin RE et al. Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324228
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Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
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Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Makrides M Is there a dietary requirement for DHA in pregnancy? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500960
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
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Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Gousset-Dupont A et al. The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17229561
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Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
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Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
Otto SJ et al. The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090260
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Horrocks LA and Farooqui AA Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041028
Harris MA et al. Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487304
Calderon F and Kim HY Role of RXR in neurite outgrowth induced by docosahexaenoic acid. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036800
Rousseau-Ralliard D et al. Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19428232
Michael-Titus AT Omega-3 fatty acids and neurological injury. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036801
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Erdogan H et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253883
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Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
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Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Qiu X Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538082
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Rahman T et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106645
Block RC et al. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106646
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
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Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
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Makrides M DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22698951
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Hishinuma T et al. Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. 1997 Prostaglandins pmid:9261859
Claeys M et al. Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. 1986 Prostaglandins pmid:2951768
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Buydens-Branchey L et al. Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. 2008 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18060675
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Doornbos B et al. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18955102