DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Dysbiosis D064806 2 associated lipids
Chronic Pain D059350 5 associated lipids
Peripheral Nerve Injuries D059348 6 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Geographic Atrophy D057092 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma D054218 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Rapoport SI Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22766388
Iwasaka H et al. Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. 2013 J Oleo Sci pmid:24005017
Fogagnolo Mauricio A et al. Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. 2013 Clin Nutr pmid:23218947
Wang D et al. Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. 2013 Ecotoxicol. Environ. Saf. pmid:24125867
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
Baum SJ EPA and DHA: distinct yet essential n-3 fatty acids. 2012 Sep-Oct J Clin Lipidol pmid:23009786
Castro González MI et al. [Renal patient's diet: Can fish be included?]. 2012 Sep-Oct Nutr Hosp pmid:23478696
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
Sanz París A et al. [Proposed profile of omega 3 fatty acids in enteral nutrition]. 2012 Nov-Dec Nutr Hosp pmid:23588426
Brown WV From the editor. 2012 Nov-Dec J Clin Lipidol pmid:23312044
Derosa G et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. 2012 Nov-Dec J Clin Lipidol pmid:23312051
Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Igarashi M et al. Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. 2012 J. Neurochem. pmid:22117540
Figueroa JD et al. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. 2012 J. Neurotrauma pmid:21970623
Lim SJ et al. Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. 2012 Oncol. Rep. pmid:22395735
Sørensen IM et al. Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. 2012 Diabetes Metab. Res. Rev. pmid:22396195
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Meesapyodsuk D and Qiu X The front-end desaturase: structure, function, evolution and biotechnological use. 2012 Lipids pmid:22009657
Rontoyanni VG et al. A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA. 2012 Br. J. Nutr. pmid:22348439
Jayashankar S et al. Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. 2012 Environ. Toxicol. Pharmacol. pmid:22056564
Meldrum SJ et al. Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial. 2012 Br. J. Nutr. pmid:22348468
Kariv-Inbal Z et al. The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. 2012 J. Alzheimers Dis. pmid:22057027
Cheon Y et al. Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice. 2012 Biochim. Biophys. Acta pmid:22349267
Antonietta Ajmone-Cat M et al. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. 2012 J. Neurosci. Res. pmid:22057807
Noreen EE and Brandauer J The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. 2012 J Complement Integr Med pmid:23104856
Kautharapu KB and Jarboe LR Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). 2012 J. Bacteriol. pmid:23105048
Wang X et al. The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). 2012 PLoS ONE pmid:23110176
Jackson PA et al. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. 2012 Biol Psychol pmid:22020134
Li N et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22020559
Morris MC Nutritional determinants of cognitive aging and dementia. 2012 Proc Nutr Soc pmid:22067138
Samaee SM and Estévez A Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. 2012 J Exp Zool A Ecol Genet Physiol pmid:22021057
Yang ZH et al. Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. 2012 Lipids Health Dis pmid:22846384
Jackson PA et al. No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. 2012 Br. J. Nutr. pmid:21864417
Morse NL Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. 2012 Nutrients pmid:22852064
Deckelbaum RJ et al. Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. 2012 J. Nutr. pmid:22323767
Harden CJ et al. Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. 2012 Br. J. Nutr. pmid:22313587
Komatsuzaki N and Shima J Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. 2012 Biosci. Biotechnol. Biochem. pmid:22313752
Silva Jde A et al. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. 2012 Nutr Cancer pmid:22295891
Mackay I et al. Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial disease. 2012 Atherosclerosis pmid:22296885
Tan Z et al. Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. 2012 Food Chem pmid:23442661
Kirkegaard E et al. Marine n-3 fatty acids, atrial fibrillation and QT interval in haemodialysis patients. 2012 Br. J. Nutr. pmid:21791142
Lopez HL Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. 2012 PM R pmid:22632694
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Cazzola R et al. Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. 2012 Exp. Gerontol. pmid:23000875
Hajjaji N et al. DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. 2012 Nutr Cancer pmid:23035949
Norris PC and Dennis EA Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22586114
Xue C et al. Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. 2012 Lipids pmid:22120618
Chiu CY et al. Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. 2012 Inflamm. Res. pmid:22618200
Pan XX et al. Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. 2012 J. Agric. Food Chem. pmid:22934819
Zhao M et al. Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. 2012 J. Nutr. pmid:22955512
Bazan NG Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. 2012 Mol. Neurobiol. pmid:22956271
Zicker SC et al. Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. 2012 J. Am. Vet. Med. Assoc. pmid:22916855
Muldoon MF Discerning whether and how long-chain, n-3 fatty acids lower blood pressure: a comment on Skulas-Ray et al. 2012 Ann Behav Med pmid:22918613
Zou XQ et al. Preparation of human milk fat substitutes from palm stearin with arachidonic and docosahexaenoic acid: combination of enzymatic and physical methods. 2012 J. Agric. Food Chem. pmid:22920386
Valentine CJ Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. 2012 Adv Nutr pmid:22585914
Ribeiro P et al. Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. 2012 Int J Food Sci Nutr pmid:21707451
Steffen BT et al. Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). 2012 Eur J Clin Nutr pmid:22215136
Odusanwo O et al. Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. 2012 Am. J. Physiol., Cell Physiol. pmid:22237406
Stein AD et al. Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. 2012 J. Nutr. pmid:22739364
Virtanen JK et al. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. 2012 PLoS ONE pmid:22815906
Thomas MC et al. Rapid identification of long-chain polyunsaturated fatty acids in a marine extract by HPLC-MS using data-dependent acquisition. 2012 Anal. Chem. pmid:22816781
Han CY et al. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. 2012 J. Biol. Chem. pmid:22287546
Landmark K and Alm CS [Fish and omega-3 fatty acids and heart failure]. 2012 Tidsskr. Nor. Laegeforen. pmid:23736195
Scheltens P et al. Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. 2012 J. Alzheimers Dis. pmid:22766770
Reinders I et al. Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. 2012 Eur J Clin Nutr pmid:22113248
Moreno-Indias I et al. Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. 2012 J. Anim. Sci. pmid:22665635
Holly LT et al. Dietary therapy to promote neuroprotection in chronic spinal cord injury. 2012 J Neurosurg Spine pmid:22735048
Wang DC et al. Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. 2012 Neurobiol. Aging pmid:20980076
Khairallah RJ et al. Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. 2012 PLoS ONE pmid:22479624
Baracos VE et al. Survival: the relevant primary outcome for nutrition therapy in cancer patients. 2012 Curr Opin Clin Nutr Metab Care pmid:22466928
Hoffmire CA et al. Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22472486
Kuipers RS et al. Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425684
Sakamoto M et al. Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. 2012 Environ Int pmid:22425897
Liao Z et al. Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. 2012 Respir. Res. pmid:23199346
Russell FD and Bürgin-Maunder CS Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. 2012 Mar Drugs pmid:23203276
Calder PC and Yaqoob P Marine omega-3 fatty acids and coronary heart disease. 2012 Curr. Opin. Cardiol. pmid:22565141
Sciotto C and Mjøs SA Trans isomers of EPA and DHA in omega-3 products on the European market. 2012 Lipids pmid:22566205
Bianchini F et al. 22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. 2012 Br. J. Nutr. pmid:22390897
Sparvero LJ et al. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. 2012 Chem. Phys. Lipids pmid:22692104
Szabó A et al. Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. 2012 Acta. Biol. Hung. pmid:22695520
Aldai N et al. Evaluating the in vitro metabolism of docosahexaenoic acid in sheep rumen fluid. 2012 Lipids pmid:22695744
Tu WC et al. An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). 2012 Biochem. Biophys. Res. Commun. pmid:22640739
Itakura H et al. The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. 2012 J. Atheroscler. Thromb. pmid:22653220
Lee HN and Surh YJ Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. 2012 Biochem. Pharmacol. pmid:23330154
Correia M et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. 2012 PLoS ONE pmid:22529974
Drzymała-Czyż S et al. Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. 2012 Folia Histochem. Cytobiol. pmid:22532147
Daud ZA et al. Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. 2012 Vasc Health Risk Manag pmid:22536073
Ginty AT and Conklin SM Preliminary evidence that acute long-chain omega-3 supplementation reduces cardiovascular reactivity to mental stress: a randomized and placebo controlled trial. 2012 Biol Psychol pmid:21967854
Aisen PS et al. Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. 2012 Cold Spring Harb Perspect Med pmid:22393531