| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dysbiosis | D064806 | 2 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Peripheral Nerve Injuries | D059348 | 6 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sayanova O and Napier JA | Transgenic oilseed crops as an alternative to fish oils. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21596549 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Kruger MC and Schollum LM | Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16154334 |
| Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Graf BA et al. | Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20580213 |
| Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
| McNamara RK | The emerging role of omega-3 fatty acids in psychiatry. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930969 |
| Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
| Shinto L et al. | Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19171471 |
| Freeman MP | Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930971 |
| Luxwolda MF et al. | The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21715149 |
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| Hanssens L et al. | The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27154364 |
| Gousset-Dupont A et al. | The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17229561 |
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| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
| Gramer G et al. | Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27269713 |
| Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Wijendran V et al. | Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24075244 |
| Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
| Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
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| Plourde M et al. | Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036804 |
| Calon F and Cole G | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18037281 |
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| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
| Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
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| Block RC et al. | The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. | 2010 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20106646 |
| Parletta N et al. | Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23756346 |
| Smit EN et al. | Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913225 |
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| Kuipers RS et al. | Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425684 |
| Magnusardottir AR et al. | Docosahexaenoic acid in red blood cells of women of reproductive age is positively associated with oral contraceptive use and physical activity. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19071003 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
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| Lokesh BR and Kinsella JE | Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846090 |
| Makrides M | DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22698951 |
| Van Biervliet S et al. | Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18276127 |
| Matsumoto K et al. | Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8302921 |
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