| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palacios A et al. | Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria. | 2003 | Mol. Cell. Biochem. | pmid:12962148 |
| Kroes R et al. | A review of the safety of DHA45-oil. | 2003 | Food Chem. Toxicol. | pmid:12962995 |
| Wheaton DH et al. | Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. | 2003 | Arch. Ophthalmol. | pmid:12963609 |
| Salem N and Pawlosky RJ | Docosahexaenoic acid is an essential nutrient in the nervous system. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297729 |
| Davis PJ | n-3 and n-6 polyunsaturated fatty acids have different effects on acyl-CoA:cholesterol acyltransferase in J774 macrophages. | 1992 | Biochem. Cell Biol. | pmid:1299268 |
| Stenson WF et al. | Dietary supplementation with fish oil in ulcerative colitis. | 1992 | Ann. Intern. Med. | pmid:1312317 |
| Hrelia S et al. | Protein kinase C activity in neonatal cultured rat cardiomyocytes supplemented with docosahexaenoic acid. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1312843 |
| Hsu JM and Ding ST | Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. | 2003 | Br. J. Nutr. | pmid:13129455 |
| Takemoto Y et al. | Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders. | 2003 | Brain Dev. | pmid:13129591 |
| Langelier B et al. | Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. | 2003 | J. Neurosci. Res. | pmid:13130515 |
| Hrelia S et al. | Fatty acid composition of phosphoinositides in cultured cardiomyocytes: effects of docosahexaenoic acid and alpha 1-adrenoceptor stimulation. | 1992 | Cardioscience | pmid:1322735 |
| Mori TA et al. | Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. | 1992 | Metab. Clin. Exp. | pmid:1328817 |
| Rice RD | Breastfeeding and intelligence. | 1992 | Lancet | pmid:1347109 |
| pmid:13471511 | ||||
| Bourre JM et al. | Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. | 1992 | Biochim. Biophys. Acta | pmid:1347458 |
| Ramsay B et al. | Erythrocyte membrane docosahexaenoic acid in haemodialysis patients on epoetin. | 1992 | Lancet | pmid:1349964 |
| Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
| Farquharson J et al. | Infant cerebral cortex phospholipid fatty-acid composition and diet. | 1992 | Lancet | pmid:1357244 |
| Ashwell M | Infant brain lipids and diet. | 1992 | Lancet | pmid:1357472 |
| Ghebremeskel K and Leighfield M | Infant brain lipids and diet. | 1992 | Lancet | pmid:1357473 |
| Sanders TA and Reddy S | Infant brain lipids and diet. | 1992 | Lancet | pmid:1357474 |
| Barceló-Coblijn G et al. | Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:13679584 |
| Naval J et al. | Expression of mRNAs for alpha-fetoprotein (AFP) and albumin and incorporation of AFP and docosahexaenoic acid in baboon fetuses. | 1992 | J. Biochem. | pmid:1379224 |
| Aukema HM et al. | Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. | 1992 | Lipids | pmid:1385849 |
| Birch DG et al. | Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. | 1992 | Invest. Ophthalmol. Vis. Sci. | pmid:1386065 |
| Anderson RE et al. | Conservation of docosahexaenoic acid in the retina. | 1992 | Adv. Exp. Med. Biol. | pmid:1386176 |
| Bazan NG et al. | Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process. | 1992 | Adv. Exp. Med. Biol. | pmid:1386177 |
| Gong J et al. | Plasma docosahexaenoic acid levels in various genetic forms of retinitis pigmentosa. | 1992 | Invest. Ophthalmol. Vis. Sci. | pmid:1386350 |
| Cabré E et al. | Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy: a preliminary study. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1386392 |
| Wargovich MJ | Fish oil and colon cancer. | 1992 | Gastroenterology | pmid:1386824 |
| Anti M et al. | Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. | 1992 | Gastroenterology | pmid:1386825 |
| Marsen TA et al. | Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1387231 |
| Chen ZY et al. | Gestational hyperlipidemia in the rat is characterized by accumulation of n - 6 and n - 3 fatty acids, especially docosahexaenoic acid. | 1992 | Biochim. Biophys. Acta | pmid:1387324 |
| Parks JS et al. | Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position. | 1992 | J. Lipid Res. | pmid:1387413 |
| Sergienko AA et al. | [Effects of docosahexaenoic and eicosapentaenoic acids on the state of metabolites of the prostacyclin I2--thromboxane A2 system in streptozotocin diabetes mellitus]. | 1992 Mar-Apr | Vopr Pitan | pmid:1387492 |
| Chen H et al. | Decreased docosahexaenoic acid levels in retina and pigment epithelium of frogs fed crickets. | 1992 | Exp. Eye Res. | pmid:1387848 |
| Sanders TA and Hinds A | The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers. | 1992 | Br. J. Nutr. | pmid:1390601 |
| Chen H et al. | Docosahexaenoic acid increases in frog retinal pigment epithelium following rod photoreceptor shedding. | 1992 | Exp. Eye Res. | pmid:1397136 |
| Du Plooy WJ et al. | The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409770 |
| Chapkin RS et al. | Phospholipid molecular species composition of mouse liver nuclei. Influence of dietary n-3 fatty acid ethyl esters. | 1992 | Biochem. J. | pmid:1417777 |
| Engler MB | Effect of omega-3 fatty acids, docosahexaenoic and eicosapentaenoic, on norepinephrine-induced contractions. | 1992 | Can. J. Physiol. Pharmacol. | pmid:1423009 |
| pmid:14259461 | ||||
| Sorci-Thomas M et al. | HepG2 cell LDL receptor activity and the accumulation of apolipoprotein B and E in response to docosahexaenoic acid and cholesterol. | 1992 | J. Lipid Res. | pmid:1431595 |
| NOBLE RC and MOORE JH | FURTHER STUDIES ON THE LIPID METABOLISM OF THE NORMAL AND VITAMIN B-12 DEFICIENT CHICK EMBRYO. | 1965 | Biochem. J. | pmid:14333549 |
| pmid:14342243 | ||||
| Martinez M | Treatment with docosahexaenoic acid favorably modifies the fatty acid composition of erythrocytes in peroxisomal patients. | 1992 | Prog. Clin. Biol. Res. | pmid:1438383 |
| Uauy-Dagach R and Valenzuela A | Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. | 1992 | Prog Food Nutr Sci | pmid:1438808 |
| Qi AD et al. | [Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]. | 1992 | Yao Xue Xue Bao | pmid:1442036 |
| Zhang CW and Richmond A | Sustainable, high-yielding outdoor mass cultures of Chaetoceros muelleri var. subsalsum and Isochrysis galbana in vertical plate reactors. | 2003 May-Jun | Mar. Biotechnol. | pmid:14502402 |
| Wolff AC et al. | Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile. | 2003 | Clin. Cancer Res. | pmid:14506145 |