Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
pmid:27886515 | ||||
pmid:27884184 | ||||
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pmid:27881040 | ||||
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
pmid:27880058 | ||||
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pmid:27878590 | ||||
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Tylichová Z et al. | Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. | 2017 | J. Nutr. Biochem. | pmid:27840291 |
pmid:27838194 | ||||
pmid:27836739 | ||||
Goda AA et al. | Astaxanthin and Docosahexaenoic Acid Reverse the Toxicity of the Maxi-K (BK) Channel Antagonist Mycotoxin Penitrem A. | 2016 | Mar Drugs | pmid:27834847 |
Zhang K et al. | Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. | 2017 | Appl. Biochem. Biotechnol. | pmid:27832512 |
Tian Y et al. | Bioconversion of Docosapentaenoic Acid in Human Cell Lines, Caco-2, HepG2, and THP-1. | 2016 | J Oleo Sci | pmid:27829615 |
pmid:27827947 | ||||
pmid:27826078 | ||||
pmid:27825781 | ||||
pmid:27825512 | ||||
Nagai T et al. | Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. | 2016 | PLoS ONE | pmid:27824904 |
pmid:27822319 | ||||
pmid:27813426 | ||||
pmid:27806659 | ||||
pmid:27806350 | ||||
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pmid:27777380 | ||||
pmid:27768981 | ||||
Marin R et al. | Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases. | 2017 | Neurobiol. Aging | pmid:27768960 |
pmid:27767993 | ||||
pmid:27765247 | ||||
pmid:27744130 | ||||
pmid:27735847 | ||||
pmid:27735833 | ||||
pmid:27733252 | ||||
Gharekhani A et al. | Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. | 2016 | Iran J Kidney Dis | pmid:27721230 |
pmid:27720041 | ||||
pmid:27720040 | ||||
pmid:27720039 | ||||
pmid:27720035 | ||||
Mason RP et al. | Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. | 2016 | Biochim. Biophys. Acta | pmid:27718370 |
pmid:27716665 | ||||
pmid:27714669 | ||||
pmid:27710160 | ||||
pmid:27707818 | ||||
Primdahl KG et al. | Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. | 2016 | J. Nat. Prod. | pmid:27704804 |
pmid:27704276 | ||||
pmid:27702480 | ||||
pmid:27701160 | ||||
pmid:27698953 | ||||
Easley JT et al. | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. | 2016 | Physiol Rep | pmid:27694530 |
pmid:27692015 | ||||
pmid:27690699 | ||||
pmid:27685803 | ||||
Crandell JR et al. | Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. | 2016 | Postgrad Med | pmid:27684412 |
pmid:27683871 | ||||
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pmid:27660991 | ||||
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Titos E et al. | Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. | 2016 | J. Immunol. | pmid:27647830 |
pmid:27647308 | ||||
Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
pmid:27637340 | ||||
pmid:27637338 |