DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang MC et al. | Placental docosahexaenoic and arachidonic acids correlate weakly with placental polychlorinated dibenzofurans (PCDF) and are uncorrelated with polychlorinated dibenzo-p-dioxins (PCDD) or polychlorinated biphenyls (PCB) at delivery: a pilot study. | 2011 | Food Chem. Toxicol. | pmid:21549173 |
| Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
| Kuipers RS et al. | Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA). | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21561751 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Larqué E et al. | Placental transfer of fatty acids and fetal implications. | 2011 | Am. J. Clin. Nutr. | pmid:21562082 |
| Draper E et al. | Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ. | 2011 | J. Nutr. Biochem. | pmid:21111596 |
| Yan J et al. | Enzymatic enrichment of polyunsaturated fatty acids using novel lipase preparations modified by combination of immobilization and fish oil treatment. | 2011 | Bioresour. Technol. | pmid:21565494 |
| Hashimoto M et al. | Docosahexaenoic acid withstands the Aβ(25-35)-induced neurotoxicity in SH-SY5Y cells. | 2011 | J. Nutr. Biochem. | pmid:20226652 |
| Tian H et al. | 14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds. | 2011 | J. Biol. Chem. | pmid:21112969 |
| Bousquet M et al. | Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. | 2011 | J. Lipid Res. | pmid:21115966 |
| Niinivirta K et al. | Dietary counseling to improve fat quality during pregnancy alters maternal fat intake and infant essential fatty acid status. | 2011 | J. Nutr. | pmid:21593355 |
| Sayanova O and Napier JA | Transgenic oilseed crops as an alternative to fish oils. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21596549 |
| Czerner M et al. | Ripening of salted anchovy (Engraulis anchoita): development of lipid oxidation, colour and other sensorial characteristics. | 2011 | J. Sci. Food Agric. | pmid:21302314 |
| Vinayavekhin N and Saghatelian A | Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. | 2011 | J. Am. Chem. Soc. | pmid:21973308 |
| Hull MA | Omega-3 polyunsaturated fatty acids. | 2011 | Best Pract Res Clin Gastroenterol | pmid:22122770 |
| Wei MY and Jacobson TA | Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. | 2011 | Curr Atheroscler Rep | pmid:21975919 |
| Turgut S et al. | The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. | 2011 | J Basic Clin Physiol Pharmacol | pmid:22865430 |
| Golub N et al. | Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. | 2011 | Med. Hypotheses | pmid:21981905 |
| Sanden M et al. | Atlantic salmon (Salmo salar L.) as a net producer of long-chain marine ω-3 fatty acids. | 2011 | J. Agric. Food Chem. | pmid:22017199 |
| Kumosani TA and Moselhy SS | Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. | 2011 | Hum Exp Toxicol | pmid:20488854 |
| Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
| Ruusunen A et al. | Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. | 2011 | Eur J Nutr | pmid:20574779 |
| Mozaffarian D et al. | Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. | 2011 | Ann. Intern. Med. | pmid:21810709 |
| Manley BJ et al. | High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. | 2011 | Pediatrics | pmid:21708809 |
| Fredman G and Serhan CN | Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. | 2011 | Biochem. J. | pmid:21711247 |
| Oh SF et al. | Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. | 2011 | Biochim. Biophys. Acta | pmid:21712098 |
| Kalupahana NS et al. | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. | 2011 | Adv Nutr | pmid:22332072 |
| Gélinas R et al. | Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21685264 |
| Wiese DM et al. | The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. | 2011 | Nutr Clin Pract | pmid:21775642 |
| Mozurkewich E et al. | The mothers, Omega-3 and mental health study. | 2011 | BMC Pregnancy Childbirth | pmid:21696635 |
| Madec S et al. | CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. | 2011 | Drug Metab. Dispos. | pmid:21778351 |
| Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
| Szajewska H and Makrides M | Is early nutrition related to short-term health and long-term outcome? | 2011 | Ann. Nutr. Metab. | pmid:21701166 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Molinari R et al. | The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. | 2011 | Cancer Immunol. Immunother. | pmid:21779875 |
| Lai LH et al. | [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21781602 |
| Serhan CN and Petasis NA | Resolvins and protectins in inflammation resolution. | 2011 | Chem. Rev. | pmid:21766791 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Murakami M | Lipid mediators in life science. | 2011 | Exp. Anim. | pmid:21325748 |
| Farina EK et al. | Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. | 2011 | Am. J. Clin. Nutr. | pmid:21367955 |
| Ohtsuka Y et al. | ω-3 fatty acids attenuate mucosal inflammation in premature rat pups. | 2011 | J. Pediatr. Surg. | pmid:21376198 |
| Stark DT and Bazan NG | Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. | 2011 | Mol. Neurobiol. | pmid:21431475 |
| Kiso Y | Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function. | 2011 | J. Pharmacol. Sci. | pmid:21436600 |
| Fernandes FS et al. | Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory. | 2011 | Nutrition | pmid:21439792 |
| Poulia KA et al. | Omega-3 fatty acids supplementation does not affect serum lipids in chronic hemodialysis patients. | 2011 | J Ren Nutr | pmid:21439849 |
| Kawabata T et al. | Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. | 2011 | Lipids Health Dis | pmid:21838914 |
| Bentley S et al. | Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis. | 2011 | Clin Ther | pmid:21440300 |
| Tian H et al. | Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. | 2011 | Am. J. Pathol. | pmid:21839062 |
| Wietrzych-Schindler M et al. | Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. | 2011 | Biol. Psychiatry | pmid:21334601 |
| Kimura F et al. | Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. | 2011 | Lipids | pmid:21901511 |
| Trojian TH and Jackson E | Ω-3 polyunsaturated fatty acids and concussions: treatment or not? | 2011 | Curr Sports Med Rep | pmid:23531891 |
| Lewis MD et al. | Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. | 2011 | J Clin Psychiatry | pmid:21903029 |
| Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
| Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
| Wagner K et al. | Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21854866 |
| Park CK et al. | Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. | 2011 | J. Neurosci. | pmid:22171045 |
| Zúñiga J et al. | N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. | 2011 | PLoS ONE | pmid:22174823 |
| Hellmann J et al. | Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. | 2011 | FASEB J. | pmid:21478260 |
| Koletzko B | Health claims: let science prevail. | 2011 | Ann. Nutr. Metab. | pmid:21454969 |
| Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
| Song KS et al. | Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. | 2011 | Pancreatology | pmid:22213040 |
| Wang B et al. | Resolvin D1 protects mice from LPS-induced acute lung injury. | 2011 | Pulm Pharmacol Ther | pmid:21501693 |
| Astarita G and Piomelli D | Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21543199 |
| Righi V et al. | EPA or DHA supplementation increases triacylglycerol, but not phospholipid, levels in isolated rat cardiomyocytes. | 2011 | Lipids | pmid:21544603 |
| Meldrum SJ et al. | The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. | 2011 | Contemp Clin Trials | pmid:21718804 |
| D'Alessandro A et al. | Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. | 2011 | J Proteomics | pmid:21723426 |
| Maki KC et al. | Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21297494 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Kong W et al. | Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:20854895 |
| Yamada T et al. | Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice. | 2011 | FASEB J. | pmid:20959515 |
| Sun C et al. | DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. | 2011 | Mol. Biol. Rep. | pmid:20383747 |
| Lynch ML et al. | Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study. | 2011 | Environ. Res. | pmid:20961536 |
| Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
| Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
| Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
| Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
| Suzuki T | Maternal depression and child development after prenatal DHA supplementation. | 2011 | JAMA | pmid:21266681 |
| Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
| Assies J et al. | Maternal depression and child development after prenatal DHA supplementation. | 2011 | JAMA | pmid:21266682 |
| Lopez LB et al. | High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the Rancho Bernardo study. | 2011 | J Nutr Health Aging | pmid:21267518 |
| Klein CM and Jenkins TC | Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. | 2011 | J. Dairy Sci. | pmid:21854940 |
| Schif-Zuck S et al. | Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. | 2011 | Eur. J. Immunol. | pmid:21268007 |
| Kuipers RS et al. | Maternal DHA equilibrium during pregnancy and lactation is reached at an erythrocyte DHA content of 8 g/100 g fatty acids. | 2011 | J. Nutr. | pmid:21270355 |
| Wang F et al. | Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. | 2011 | Curr. Mol. Med. | pmid:21663587 |
| Lima-Garcia JF et al. | The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. | 2011 | Br. J. Pharmacol. | pmid:21418187 |
| Nagao T et al. | One-pot enzymatic synthesis of docosahexaenoic acid-rich triacylglycerols at the sn-1(3) position using by-product from selective hydrolysis of tuna oil. | 2011 | N Biotechnol | pmid:20709631 |
| Cortina MS and Bazan HE | Docosahexaenoic acid, protectins and dry eye. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21157308 |
| Schwinkendorf DR et al. | Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism. | 2011 | Int J Obes (Lond) | pmid:20714328 |
| DeFina LF et al. | Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. | 2011 | Am. J. Clin. Nutr. | pmid:21159785 |
| Mihailescu M et al. | Structure and dynamics of cholesterol-containing polyunsaturated lipid membranes studied by neutron diffraction and NMR. | 2011 | J. Membr. Biol. | pmid:21161517 |
| Tishinsky JM et al. | Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytes. | 2011 | Obesity (Silver Spring) | pmid:20814411 |
| Am-in N et al. | Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. | 2011 | Theriogenology | pmid:21167582 |
| Siener R et al. | Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation. | 2011 | J. Urol. | pmid:21168878 |
| Nowak M et al. | Impact of polyunsaturated fatty acids on oxidized low density lipoprotein-induced U937 cell apoptosis. | 2011 | J. Atheroscler. Thromb. | pmid:21325776 |
| Murphy RA et al. | Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. | 2011 | Cancer | pmid:21328326 |
| Valera B et al. | Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. | 2011 | Int J Circumpolar Health | pmid:21329579 |
| Furuhjelm C et al. | Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. | 2011 | Pediatr Allergy Immunol | pmid:21332799 |
| Sriram K | Confusion between gamma-linolenic acid and gamma-linoleic acid. | 2011 | Crit. Care Med. | pmid:22094528 |
| Scott SD et al. | Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. | 2011 | Enzyme Microb. Technol. | pmid:22112910 |