Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kotani S et al. | Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. | 2006 | Neurosci. Res. | pmid:16905216 |
Bays H | Clinical overview of Omacor: a concentrated formulation of omega-3 polyunsaturated fatty acids. | 2006 | Am. J. Cardiol. | pmid:16919519 |
Hall JA et al. | The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. | 2006 | J. Nutr. | pmid:16920851 |
Mori TA | Omega-3 fatty acids and hypertension in humans. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16922818 |
German OL et al. | Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. | 2006 | J. Neurochem. | pmid:16923163 |
Helland IB et al. | Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. | 2006 | J. Matern. Fetal. Neonatal. Med. | pmid:16923694 |
Burdge GC et al. | Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets. | 2006 | Br. J. Nutr. | pmid:16925854 |
Serhan CN | Novel chemical mediators in the resolution of inflammation: resolvins and protectins. | 2006 | Anesthesiol Clin | pmid:16927933 |
McNamara RK | The emerging role of omega-3 fatty acids in psychiatry. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930969 |
Freeman MP | Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16930971 |
Isbilen B et al. | Docosahexaenoic acid (omega-3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16931105 |
Hashimoto M et al. | Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. | 2006 | Mol. Cell. Biochem. | pmid:16933035 |
Kojima Y et al. | Different specificity of two types of Pseudomonas lipases for C20 fatty acids with a Delta5 unsaturated double bond and their application for selective concentration of fatty acids. | 2006 | J. Biosci. Bioeng. | pmid:16935251 |
Mollard RC and Weiler HA | Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in piglets. | 2006 | Pediatr. Res. | pmid:16940244 |
Dangour AD et al. | A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. | 2006 | Nutr J | pmid:16945130 |
McNamara RK and Carlson SE | Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16949263 |
Morris T et al. | New perspectives on aspirin and the endogenous control of acute inflammatory resolution. | 2006 | ScientificWorldJournal | pmid:16951898 |
Xu Y et al. | Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure. | 2007 | Arch. Toxicol. | pmid:16951938 |
Nieminen LR et al. | Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16959481 |
Sanders TA et al. | Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study. | 2006 | Am. J. Clin. Nutr. | pmid:16960164 |
Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
Lee M and Bae MA | Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. | 2007 | J. Nutr. Biochem. | pmid:16963249 |
Yonezawa Y et al. | Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. | 2006 | Int. J. Mol. Med. | pmid:16964408 |
Egert S et al. | Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers. | 2007 | Eur J Clin Nutr | pmid:16969378 |
Pappas AC et al. | Maternal organo-selenium compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the chick tissues. | 2006 | Poult. Sci. | pmid:16977847 |
Yao HT et al. | The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. | 2006 | Life Sci. | pmid:16978661 |
Hacioglu G et al. | Beneficial effects of docosahexaenoic acid on active avoidance performance in 1K-1C hypertensive rats. | 2007 | Neurobiol Learn Mem | pmid:16979916 |
Marosvölgyi T et al. | [Fatty acid composition of human milk in mothers of preterm and full-term infants in the first three weeks of lactation]. | 2006 | Orv Hetil | pmid:16981419 |
Kao BT et al. | Mice raised on milk transgenically enriched with n-3 PUFA have increased brain docosahexaenoic acid. | 2006 | Lipids | pmid:16981432 |
Erkkilä AT et al. | Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. | 2006 | J. Lipid Res. | pmid:16983146 |
Rao JS et al. | n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. | 2007 | Mol. Psychiatry | pmid:16983391 |
Rao JS et al. | Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. | 2007 | Mol. Psychiatry | pmid:16983392 |
Orikasa Y et al. | Recombinant production of docosahexaenoic acid in a polyketide biosynthesis mode in Escherichia coli. | 2006 | Biotechnol. Lett. | pmid:16988784 |
[Start of insulin therapy. How to ensure patient compliance?]. | 2006 | MMW Fortschr Med | pmid:16995354 | |
Hashimoto M et al. | Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:17002670 |
Machová E et al. | The increase of choline acetyltransferase activity by docosahexaenoic acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth. | 2006 | Neurochem. Res. | pmid:17004129 |
Zlatanos S et al. | Proximate composition, fatty acid analysis and protein digestibility-corrected amino acid score of three Mediterranean cephalopods. | 2006 | Mol Nutr Food Res | pmid:17009215 |
Rupp H | [Omega-3 fatty acids in secondary prevention after myocardial infarct]. | 2006 | Clin Res Cardiol | pmid:17013579 |
Lau CS | Collateral benefits of fish oil therapy for rheumatoid arthritis. | 2006 | J. Rheumatol. | pmid:17014011 |
Sunada S et al. | Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress. | 2006 | Free Radic. Res. | pmid:17015262 |
Massaro M et al. | The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17018645 |
Colas S et al. | Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: a role for tumor vascularization. | 2006 | Clin. Cancer Res. | pmid:17020996 |
Larqué E et al. | Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. | 2006 | Am. J. Clin. Nutr. | pmid:17023713 |
Serna-Saldivar SO et al. | Effect of DHA containing oils and powders on baking performance and quality of white pan bread. | 2006 | Plant Foods Hum Nutr | pmid:17031604 |
Abuzaytoun R and Shahidi F | Oxidative stability of algal oils as affected by their minor components. | 2006 | J. Agric. Food Chem. | pmid:17032036 |
Puglia C et al. | Protective effect of Mediterranean fish oil extracts on heat-induced denaturation of albumin. | 2006 | J. Pharm. Pharmacol. | pmid:17034666 |
Kuriki K et al. | Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids. | 2006 | Cancer Epidemiol. Biomarkers Prev. | pmid:17035384 |
Pastor N et al. | Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life. | 2006 | Clin Pediatr (Phila) | pmid:17041174 |
Igarashi M et al. | Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. | 2007 | J. Lipid Res. | pmid:17050905 |
Horia E and Watkins BA | Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. | 2007 | Carcinogenesis | pmid:17052999 |
Cao J et al. | Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. | 2006 | Clin. Chem. | pmid:17053155 |
Hong S et al. | Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17055291 |
Duffield JS et al. | Resolvin D series and protectin D1 mitigate acute kidney injury. | 2006 | J. Immunol. | pmid:17056514 |
González-Périz A et al. | Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. | 2006 | FASEB J. | pmid:17056761 |
Søgaard R et al. | GABA(A) receptor function is regulated by lipid bilayer elasticity. | 2006 | Biochemistry | pmid:17059229 |
Tang XH et al. | Cell proliferation inhibition and alterations in retinol esterification induced by phytanic acid and docosahexaenoic acid. | 2007 | J. Lipid Res. | pmid:17068359 |
Osako K et al. | Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus. | 2006 | Lipids | pmid:17069355 |
Krabbendam L et al. | Relationship between DHA status at birth and child problem behaviour at 7 years of age. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17074476 |
Hulbert AJ et al. | Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice. | 2006 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:17077193 |
Brown M et al. | Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. | 2007 | Blood | pmid:17077332 |
Luczaj W and Skrzydlewska E | [The present-day look at lipid peroxidation]. | 2006 | Postepy Biochem. | pmid:17078507 |
Tanaka H et al. | Promotive effects of hyperthermia on the inhibition of DNA synthesis in ehrlich ascites tumor cells by eicosapentaenoic and docosahexaenoic acids. | 2006 | Exp. Oncol. | pmid:17080013 |
Hall JA et al. | Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17081738 |
White NM et al. | Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17085523 |
Hamaad A et al. | Oral omega n3-PUFA therapy (Omacor) has no impact on indices of heart rate variability in stable post myocardial infarction patients. | 2006 | Cardiovasc Drugs Ther | pmid:17089085 |
Serhan CN | Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. | 2007 | Annu. Rev. Immunol. | pmid:17090225 |
Beharry S et al. | Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17095751 |
Almendingen K et al. | Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. | 2007 | Int. J. Cancer | pmid:17096349 |
Eto K et al. | Modulation of ATP-induced inward currents by docosahexaenoic acid and other fatty acids in rat nodose ganglion neurons. | 2006 | J. Pharmacol. Sci. | pmid:17099292 |
Morris MC | Docosahexaenoic acid and Alzheimer disease. | 2006 | Arch. Neurol. | pmid:17101820 |
Schaefer EJ et al. | Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. | 2006 | Arch. Neurol. | pmid:17101822 |
Buydens-Branchey L and Branchey M | n-3 polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers. | 2006 | J Clin Psychopharmacol | pmid:17110827 |
Berdeaux O et al. | Isolation and structural analysis of the cyclic fatty acid monomers formed from eicosapentaenoic and docosahexaenoic acids during fish oil deodorization. | 2007 | J Chromatogr A | pmid:17113094 |
Coetzee M et al. | Effects of arachidonic acid, docosahexaenoic acid and prostaglandin E(2) on cell proliferation and morphology of MG-63 and MC3T3-E1 osteoblast-like cells. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17113274 |
Hartong DT et al. | Retinitis pigmentosa. | 2006 | Lancet | pmid:17113430 |
Mathur SN et al. | Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid. | 2007 | J. Lipid Res. | pmid:17114806 |
Coronel R et al. | Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts. | 2007 | Cardiovasc. Res. | pmid:17116294 |
Kim HK et al. | Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes. | 2006 | J. Nutr. | pmid:17116704 |
Okuyama H et al. | Bacterial genes responsible for the biosynthesis of eicosapentaenoic and docosahexaenoic acids and their heterologous expression. | 2007 | Appl. Environ. Microbiol. | pmid:17122401 |
Harris WS et al. | Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients. | 2006 | Am. J. Cardiol. | pmid:17134636 |
Miller MR et al. | Replacement of dietary fish oil for Atlantic salmon parr (Salmo salar L.) with a stearidonic acid containing oil has no effect on omega-3 long-chain polyunsaturated fatty acid concentrations. | 2007 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:17134928 |
Alimuddin G et al. | Expression of masu salmon delta5-desaturase-like gene elevated EPA and DHA biosynthesis in zebrafish. | 2007 Jan-Feb | Mar. Biotechnol. | pmid:17136489 |
Kanayasu T et al. | Eicosapentaenoic acid inhibits tube formation of vascular endothelial cells in vitro. | 1991 | Lipids | pmid:1714032 |
van Beelen VA et al. | A comparative study on the effect of algal and fish oil on viability and cell proliferation of Caco-2 cells. | 2007 | Food Chem. Toxicol. | pmid:17141934 |
Shirai N and Suzuki H | Effect of docosahexaenoic acid on brain 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in male ICR mice. | 2007 | J. Nutr. Biochem. | pmid:17142030 |
Yuhas R et al. | Human milk fatty acid composition from nine countries varies most in DHA. | 2006 | Lipids | pmid:17152922 |
Champeil-Potokar G et al. | Docosahexaenoic acid (22:6n-3) enrichment of membrane phospholipids increases gap junction coupling capacity in cultured astrocytes. | 2006 | Eur. J. Neurosci. | pmid:17156369 |
Griffin MD et al. | Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. | 2006 | Am. J. Clin. Nutr. | pmid:17158408 |
Philibert A et al. | Fish intake and serum fatty acid profiles from freshwater fish. | 2006 | Am. J. Clin. Nutr. | pmid:17158409 |
Kamphuis MH et al. | Depression and cardiovascular mortality: a role for n-3 fatty acids? | 2006 | Am. J. Clin. Nutr. | pmid:17158437 |
Demonty I et al. | Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. | 2006 | Am. J. Clin. Nutr. | pmid:17158440 |
Carlson BA and Kingston JD | Docosahexaenoic acid, the aquatic diet, and hominin encephalization: difficulties in establishing evolutionary links. | 2007 Jan-Feb | Am. J. Hum. Biol. | pmid:17160979 |
Domingo JL et al. | Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. | 2007 | Toxicology | pmid:17161894 |
Narayanan BA | Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. | 2006 | Curr Cancer Drug Targets | pmid:17168675 |
Broersen K et al. | Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation. | 2006 | Biochemistry | pmid:17176082 |
De Truchis P et al. | Reduction in triglyceride level with N-3 polyunsaturated fatty acids in HIV-infected patients taking potent antiretroviral therapy: a randomized prospective study. | 2007 | J. Acquir. Immune Defic. Syndr. | pmid:17179770 |
Cole GM and Frautschy SA | Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. | 2006 | Nutr Health | pmid:17180870 |
Yavin E | Docosahexaenoic acid: a pluripotent molecule acting as a membrane fluidizer, a cellular antioxidant and a modulator of gene expression. | 2006 | Nutr Health | pmid:17180871 |
Crawford MA | Docosahexaenoic acid in neural signaling systems. | 2006 | Nutr Health | pmid:17180872 |
Levy BD et al. | Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. | 2007 | J. Immunol. | pmid:17182589 |