DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ashford A et al. | Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. | 2000 | Lipids | pmid:11202000 |
| al-Awadhi AM and Dunn CD | Effects of fish-oil constituents and plasma lipids on fibrinolysis in vitro. | 2000 | Br. J. Biomed. Sci. | pmid:11204855 |
| Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
| Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
| Hung P et al. | Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11210121 |
| Song JH and Miyazawa T | Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. | 2001 | Atherosclerosis | pmid:11223421 |
| Christophe A and Robberecht E | Directed modification instead of normalization of fatty acid patterns in cystic fibrosis: an emerging concept. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11224654 |
| Saito M | Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids. | 2000 | Biofactors | pmid:11237175 |
| Hamazaki T et al. | Anti-stress effects of DHA. | 2000 | Biofactors | pmid:11237197 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| van den Ham EC et al. | Evaluation of the relation between n-3 and n-6 fatty acid status and parity in nonpregnant women from the Netherlands. | 2001 | Am. J. Clin. Nutr. | pmid:11237941 |
| Infante JP and Huszagh VA | Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. | 2001 | Mol. Genet. Metab. | pmid:11243724 |
| Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
| Al MD et al. | Relation between birth order and the maternal and neonatal docosahexaenoic acid status. | 1997 | Eur J Clin Nutr | pmid:11248881 |
| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. | 2001 | Clin. Exp. Pharmacol. Physiol. | pmid:11251638 |
| Wood H | An X-orphan. | 2001 | Nat. Rev. Neurosci. | pmid:11252996 |
| Pound EM et al. | Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. | 2001 | J. Lipid Res. | pmid:11254745 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. | 2001 | J. Lipid Res. | pmid:11254753 |
| Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |