DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ratnayake WM et al. | Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. | 1997 | Br. J. Nutr. | pmid:9306886 |
| Gibson RA et al. | Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. | 1997 | Eur J Clin Nutr | pmid:9306083 |
| Carvajal O and Angulo O | Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. | 1997 May-Jun | Salud Publica Mex | pmid:9304226 |
| Colombo DT et al. | Comparison of hexadecylphosphocholine with fish oil as an antitumor agent. | 1997 | J Lipid Mediat Cell Signal | pmid:9302654 |
| Lovegrove JA et al. | Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. | 1997 | Br. J. Nutr. | pmid:9301413 |
| Brossard N et al. | Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. | 1997 | J. Lipid Res. | pmid:9300779 |
| Van Elswyk ME | Comparison of n-3 fatty acid sources in laying hen rations for improvement of whole egg nutritional quality: a review. | 1997 | Br. J. Nutr. | pmid:9292775 |
| Jensen CL et al. | Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. | 1997 | J. Pediatr. | pmid:9290604 |
| Carlson SE | Functional effects of increasing omega-3 fatty acid intake. | 1997 | J. Pediatr. | pmid:9290597 |
| Suzuki H et al. | Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9285258 |
| Grimsgaard S et al. | Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. | 1997 | Am. J. Clin. Nutr. | pmid:9280188 |
| Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
| Weete JD et al. | Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. | 1997 | Lipids | pmid:9270975 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
| Hishinuma T et al. | Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. | 1997 | Prostaglandins | pmid:9261859 |
| Kanazawa A et al. | Increased hepatic beta-oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid-enriched diet. | 1997 | Lipids | pmid:9252962 |
| Vidgren HM et al. | Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. | 1997 | Lipids | pmid:9252957 |
| Oliveira FL et al. | Triglyceride hydrolysis of soy oil vs fish oil emulsions. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252949 |
| Schønberg SA and Skorpen F | Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. | 1997 Jul-Aug | Anticancer Res. | pmid:9252660 |
| Rotstein NP et al. | Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. | 1997 | J. Neurochem. | pmid:9231708 |
| Takahashi M et al. | Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9230276 |
| Huang ZH et al. | N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. | 1997 | Biochem. J. | pmid:9230140 |
| Panchenko VM et al. | [Effects of eifitol on lipid metabolism in patients with clinically different ischemic heart diseases]. | 1997 | Klin Med (Mosk) | pmid:9229613 |
| Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
| Hempenius RA et al. | Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. | 1997 | Food Chem. Toxicol. | pmid:9225015 |
| Reynaud D and Pace-Asciak CR | Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. | 1997 | Biochim. Biophys. Acta | pmid:9219915 |
| Murakami T et al. | Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9219094 |
| Petrukhina GN et al. | [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. | 1997 Mar-Apr | Eksp Klin Farmakol | pmid:9206567 |
| Innis SM and Dyer R | Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. | 1997 | J. Nutr. | pmid:9202085 |
| Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9186612 |
| Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
| Ikemoto A et al. | Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. | 1997 | Neurochem. Res. | pmid:9178949 |
| Jones CR et al. | Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. | 1997 | Neurochem. Res. | pmid:9178948 |
| Shimura T et al. | Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). | 1997 | Biol. Pharm. Bull. | pmid:9178930 |
| Connor WE et al. | Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. | 1997 | J. Clin. Endocrinol. Metab. | pmid:9177405 |
| Davidson MH et al. | Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. | 1997 | J Am Coll Nutr | pmid:9176830 |
| Allard JP et al. | Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. | 1997 | Lipids | pmid:9168460 |
| Bell JG et al. | The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. | 1997 | Lipids | pmid:9168458 |
| Stillwell W et al. | Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. | 1997 | Lipids | pmid:9168456 |
| Jumpsen J et al. | Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. | 1997 | J. Nutr. | pmid:9164993 |
| Benassayag C et al. | High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. | 1997 | J. Lipid Res. | pmid:9162747 |
| Green P et al. | Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. | 1997 | J. Neurosci. Res. | pmid:9160249 |
| Buzzi M et al. | Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9159889 |
| Andreassen AK et al. | Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. | 1997 | J. Am. Coll. Cardiol. | pmid:9137231 |
| Gordon N | Nutrition and cognitive function. | 1997 | Brain Dev. | pmid:9134186 |
| Oski FA | What we eat may determine who we can be. | 1997 | Nutrition | pmid:9131682 |
| Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
| Tamura M and Suzuki H | Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9129257 |
| Heird WC et al. | Docosahexaenoic acid and the development and function of the infant retina. | 1997 | Curr. Opin. Lipidol. | pmid:9127705 |
| Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |