DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reardon HT et al. | Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22398025 |
| Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
| Daak AA et al. | Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24095588 |
| Umhau JC et al. | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. | 2013 | PLoS ONE | pmid:24098376 |
| Renganathan K et al. | CEP biomarkers as potential tools for monitoring therapeutics. | 2013 | PLoS ONE | pmid:24098476 |
| Hegarty B and Parker G | Fish oil as a management component for mood disorders - an evolving signal. | 2013 | Curr Opin Psychiatry | pmid:23108232 |
| Ren LJ et al. | Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. | 2013 | Bioprocess Biosyst Eng | pmid:23108442 |
| Kautharapu KB et al. | Growth condition optimization for docosahexaenoic acid (DHA) production by Moritella marina MP-1. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23111600 |
| MacLean E et al. | n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. | 2013 | Br. J. Nutr. | pmid:22849952 |
| Hajjaji N and Bougnoux P | Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. | 2013 | Cancer Treat. Rev. | pmid:22850619 |
| Yang T et al. | N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. | 2013 | J. Nutr. Biochem. | pmid:22854319 |
| Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
| Faizan M et al. | Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). | 2013 | Int J Vitam Nutr Res | pmid:25008014 |
| Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
| Nordgren TM et al. | Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. | 2013 | Respir. Res. | pmid:23663457 |
| Izquierdo MS et al. | Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. | 2013 | Br. J. Nutr. | pmid:23046500 |
| Hara M et al. | Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. | 2013 | Circ. J. | pmid:23047296 |
| Kasuya F et al. | Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. | 2013 | J Enzyme Inhib Med Chem | pmid:22299587 |
| Lapillonne A et al. | Lipid needs of preterm infants: updated recommendations. | 2013 | J. Pediatr. | pmid:23445847 |
| West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
| Sánchez-MartÃn MJ et al. | Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. | 2013 | Chembiochem | pmid:23447332 |
| Dacks PA et al. | Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. | 2013 | J Nutr Health Aging | pmid:23459977 |
| Skilton MR et al. | High intake of dietary long-chain ω-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008. | 2013 | Hypertension | pmid:23460284 |
| Kurihara T et al. | Resolvin D2 restores neutrophil directionality and improves survival after burns. | 2013 | FASEB J. | pmid:23430978 |
| Snodgrass RG et al. | Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. | 2013 | J. Immunol. | pmid:24043885 |
| McNamara RK et al. | Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. | 2013 | J Psychiatr Res | pmid:23759469 |
| Nielsen G et al. | Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. | 2013 | Basic Clin. Pharmacol. Toxicol. | pmid:23724868 |
| Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
| De Genaro P et al. | Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23580485 |
| Hudson AG et al. | Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. | 2013 | Nutr Cancer | pmid:23530640 |
| Pacetti D et al. | Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). | 2013 | J. Agric. Food Chem. | pmid:23531042 |
| Mozurkewich EL et al. | The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531328 |
| Romero VC et al. | Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531329 |
| Xue Z et al. | Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. | 2013 | Nat. Biotechnol. | pmid:23873085 |
| Pase MP and Stough C | Describing a taxonomy of cognitive processes for clinical trials assessing cognition. | 2013 | Am. J. Clin. Nutr. | pmid:23873682 |
| Kuratko CN et al. | The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. | 2013 | Nutrients | pmid:23877090 |
| Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
| Vigerust NF et al. | Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. | 2013 | Eur J Nutr | pmid:22923017 |
| Marty-Roix R and Lien E | (De-) oiling inflammasomes. | 2013 | Immunity | pmid:23809158 |
| Yan Y et al. | Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. | 2013 | Immunity | pmid:23809162 |
| Wu A et al. | Exercise facilitates the action of dietary DHA on functional recovery after brain trauma. | 2013 | Neuroscience | pmid:23811071 |
| Sugasini D and Lokesh BR | Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. | 2013 | Mol. Cell. Biochem. | pmid:23812902 |
| Damsgaard CT et al. | n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. | 2013 | Br. J. Nutr. | pmid:23591057 |
| Erken HA et al. | Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. | 2013 | High Alt. Med. Biol. | pmid:24377343 |
| Oelrich B et al. | Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:21924882 |
| Tapsell LC et al. | Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. | 2013 | BMC Public Health | pmid:24369765 |
| van Valenberg HJ et al. | Concentrations of n-3 and n-6 fatty acids in Dutch bovine milk fat and their contribution to human dietary intake. | 2013 | J. Dairy Sci. | pmid:23664339 |
| Ribeiro T et al. | Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. | 2013 | Br. Poult. Sci. | pmid:24397512 |
| Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
| Thomas J et al. | Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. | 2013 | J. Nutr. Biochem. | pmid:23746933 |
| Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
| Chang G et al. | Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. | 2013 | Bioresour. Technol. | pmid:23747449 |
| Zhang L et al. | Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. | 2013 | Bioresour. Technol. | pmid:23751810 |
| Janczyk W et al. | Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. | 2013 | BMC Pediatr | pmid:23702094 |
| Cortina MS et al. | Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23702780 |
| Nyuar KB et al. | Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23706881 |
| Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
| Kelly OJ et al. | Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. | 2013 | Nutr Res | pmid:23827126 |
| GarcÃa-Sastre A | Lessons from lipids in the fight against influenza. | 2013 | Cell | pmid:23827671 |
| Birch DG et al. | Spectral-domain optical coherence tomography measures of outer segment layer progression in patients with X-linked retinitis pigmentosa. | 2013 | JAMA Ophthalmol | pmid:23828615 |
| Mobraten K et al. | Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. | 2013 | Lipids Health Dis | pmid:23849180 |
| Martins DA et al. | Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. | 2013 | Mar Drugs | pmid:23807546 |
| Chen HF and Su HM | Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. | 2013 | J. Nutr. Biochem. | pmid:22818715 |
| Brahmbhatt V et al. | Protective effects of dietary EPA and DHA on ischemia-reperfusion-induced intestinal stress. | 2013 | J. Nutr. Biochem. | pmid:22819560 |
| Benton D et al. | Supplementation with DHA and the psychological functioning of young adults. | 2013 | Br. J. Nutr. | pmid:22715808 |
| Collins MA et al. | Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | 2013 | Neurotox Res | pmid:23184649 |
| Kusunoki C et al. | Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23131562 |
| Li C et al. | High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. | 2013 | Bioresour. Technol. | pmid:23131649 |
| Nicholson T et al. | The role of marine n-3 fatty acids in improving cardiovascular health: a review. | 2013 | Food Funct | pmid:23325431 |
| Flock MR et al. | Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. | 2013 | Diabetes Metab. Res. Rev. | pmid:23592441 |
| Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
| Mortensen K and Tawia S | Sustained breastfeeding. | 2013 | Breastfeed Rev | pmid:23600325 |
| Harsløf LB et al. | FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. | 2013 | Am. J. Clin. Nutr. | pmid:23636240 |
| Kangari H et al. | Short-term consumption of oral omega-3 and dry eye syndrome. | 2013 | Ophthalmology | pmid:23642375 |
| Tanghe S et al. | Echium oil and linseed oil as alternatives for fish oil in the maternal diet: Blood fatty acid profiles and oxidative status of sows and piglets. | 2013 | J. Anim. Sci. | pmid:23658328 |
| Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
| Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
| Ishikado A et al. | 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. | 2013 | PLoS ONE | pmid:23936010 |
| Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
| Sadli N et al. | Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. | 2013 | Cell. Physiol. Biochem. | pmid:23942088 |
| Rajasagi NK et al. | Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23942967 |
| Mühlroth A et al. | Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. | 2013 | Mar Drugs | pmid:24284429 |
| Betancor MB et al. | Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23202658 |
| Crawford MA et al. | A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23206328 |
| Kim K et al. | A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. | 2013 | Bioresour. Technol. | pmid:23206808 |
| Pomponi M et al. | Plasma levels of n-3 fatty acids in bipolar patients: deficit restricted to DHA. | 2013 | J Psychiatr Res | pmid:23207113 |
| de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
| Valentine CJ et al. | Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors. | 2013 | Breastfeed Med | pmid:22568471 |
| Tomita T et al. | High concentrations of omega-3 fatty acids are associated with the development of atrial fibrillation in the Japanese population. | 2013 | Heart Vessels | pmid:22696184 |
| Makrides M | DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22698951 |
| Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
| Orr SK et al. | Unesterified docosahexaenoic acid is protective in neuroinflammation. | 2013 | J. Neurochem. | pmid:23919613 |
| Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |
| Stanley WC et al. | Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. | 2013 | J Cardiovasc Transl Res | pmid:24065618 |
| Xiao G et al. | Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. | 2013 | PLoS ONE | pmid:24066055 |
| Lachance C et al. | Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. | 2013 | PLoS ONE | pmid:24069363 |
| McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
| Sun SN et al. | Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. | 2013 | Int J Clin Exp Pathol | pmid:23330014 |
| Bogl LH et al. | Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23333726 |
| Depner CM et al. | Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. | 2013 | J. Nutr. | pmid:23303872 |