Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Storey A et al. | Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. | 2005 | J. Invest. Dermatol. | pmid:15654981 |
Marszalek JR et al. | Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. | 2005 | J. Biol. Chem. | pmid:15655248 |
Katsumata T and Katayama Y | [Icosapentanoic acid (EPA), docosahexanoic acid (DHA)]. | 2004 | Nippon Rinsho | pmid:15658280 |
Chiu LC et al. | Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659818 |
Yamamoto K et al. | Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15664804 |
Sul D et al. | Benzene increases the ratio of arachidonic acids to docosahexaenoic acids and inhibits the de novo synthesis of ceramide in the rat liver. | 2005 Jan-Feb | J Appl Toxicol | pmid:15669040 |
Du ZY et al. | Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. | 2004 | Lipids | pmid:15669760 |
Verlengia R et al. | Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. | 2004 | Lipids | pmid:15669761 |
Mutch DM et al. | An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. | 2005 | FASEB J. | pmid:15670975 |
Gerbi A et al. | Dose dependent accretion of docosahexaenoic acid (DHA) in cardiac membranes of rats fed egg yolk powder enriched in DHA. | 2004 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:15672470 |
Gleize B et al. | Docosahexaenoic acid-enriched egg phospholipids supplementation induces accretion of arachidonic acid in rat blood lipids. | 2004 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:15672471 |
Turner AJ et al. | Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681797 |
Szabó A et al. | Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. | 2005 | Poult. Sci. | pmid:15685949 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Rajamoorthi K et al. | Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. | 2005 | J. Am. Chem. Soc. | pmid:15686391 |
Beblo S et al. | Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. | 2005 | Pediatrics | pmid:15687427 |
Økland HM et al. | Proximate composition, fatty acid and lipid class composition of the muscle from deep-sea teleosts and elasmobranchs. | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15694592 |
Okuda N et al. | Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study. | 2005 | Atherosclerosis | pmid:15694947 |
Li H et al. | EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. | 2005 | Kidney Int. | pmid:15698426 |
Geelen A et al. | Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. | 2005 | Am. J. Clin. Nutr. | pmid:15699229 |
Narayanan NK et al. | A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. | 2005 | Int. J. Oncol. | pmid:15703837 |
Gronert K et al. | A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. | 2005 | J. Biol. Chem. | pmid:15708862 |
Serhan CN | Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716788 |
Groh-Wargo S et al. | Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. | 2005 | Pediatr. Res. | pmid:15718356 |
GarcÃa-Calatayud S et al. | Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. | 2005 | Pediatr. Res. | pmid:15718358 |
Kojima M et al. | Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. | 2005 | Am. J. Epidemiol. | pmid:15718482 |
Brinsko SP et al. | Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. | 2005 | Theriogenology | pmid:15725455 |
Anderson RE and Penn JS | Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. | 2004 | Lipids | pmid:15726827 |
Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. | 2004 | Lipids | pmid:15726828 |
Mollard RC et al. | Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit. | 2005 | J. Nutr. | pmid:15735085 |
Hashimoto M et al. | Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. | 2005 | J. Nutr. | pmid:15735092 |
Valenzuela A et al. | Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats. | 2005 Jan-Feb | Ann. Nutr. Metab. | pmid:15735367 |
Aro TL et al. | Fatty acids and fat-soluble vitamins in salted herring (Clupea harengus) products. | 2005 | J. Agric. Food Chem. | pmid:15740028 |
Itomura M et al. | The effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trial. | 2005 | J. Nutr. Biochem. | pmid:15741051 |
Goirand F et al. | Effect of dietary docosahexaenoic acid on the endothelium-dependent vasorelaxation in diabetic rats. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743401 |
Van Biervliet S et al. | Docosahexaenoic acid trials in cystic fibrosis: a review of the rationale behind the clinical trials. | 2005 | J. Cyst. Fibros. | pmid:15752678 |
Alessandri JM et al. | Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. | 2004 Nov-Dec | Reprod. Nutr. Dev. | pmid:15762297 |
Kuipers RS et al. | High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15763440 |
Niu SL et al. | Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. | 2005 | Biochemistry | pmid:15766276 |
Shim SM et al. | Mercury and omega-3 fatty acids in retail fish sandwiches. | 2005 | J. Food Prot. | pmid:15771197 |
Draganov DI et al. | Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. | 2005 | J. Lipid Res. | pmid:15772423 |
Denkins Y et al. | Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. | 2005 | J. Lipid Res. | pmid:15772428 |
Simon HB | On call. I was impressed by your July 2004 article on fish oil, and I'm thinking of taking it. I remember that my mother gave me a spoonful of cod liver oil every day. Would it be a good thing for me to have today? | 2005 | Harv Mens Health Watch | pmid:15773012 |
Berry CB et al. | Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid. | 2005 | Brain Res. | pmid:15777760 |
Engler MM et al. | Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). | 2005 | Am. J. Cardiol. | pmid:15781019 |
Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
Araseki M et al. | Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15784975 |
Cha MC et al. | Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity. | 2005 | BMC Pharmacol. | pmid:15788091 |
Lim GP et al. | A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. | 2005 | J. Neurosci. | pmid:15788759 |
Kim HJ et al. | Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. | 2005 | J. Cell. Physiol. | pmid:15795939 |
Thomas CP and Heard CM | In vitro transcutaneous delivery of ketoprofen and essential polyunsaturated fatty acids from a fish oil vehicle incorporating 1,8-cineole. | 2005 Jan-Feb | Drug Deliv | pmid:15801715 |
Gederaas OA et al. | Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. | 2005 | Photochem. Photobiol. Sci. | pmid:15803209 |
Zhang Q and Ma Y | [Determination of EPA and DHA in marine microalgaes by GC]. | 2004 | Se Pu | pmid:15807130 |
Fickl H et al. | Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. | 2005 | Clin. Exp. Immunol. | pmid:15807851 |
Ren H et al. | Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease. | 2005 | Ann. Hematol. | pmid:15809883 |
Clandinin MT et al. | Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. | 2005 | J. Pediatr. | pmid:15812447 |
Birch EE et al. | Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. | 2005 | Am. J. Clin. Nutr. | pmid:15817866 |
Abuissa H et al. | Autonomic function, omega-3, and cardiovascular risk. | 2005 | Chest | pmid:15821175 |
Patten GS et al. | Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil. | 2005 | Lipids | pmid:15825832 |
Goyens PL et al. | Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. | 2005 | J. Lipid Res. | pmid:15834128 |
Innis SM | Essential fatty acid transfer and fetal development. | 2005 | Placenta | pmid:15837071 |
Weatherill AR et al. | Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. | 2005 | J. Immunol. | pmid:15843537 |
Lytle JS et al. | Stability of a commercially prepared fish oil (omega-3 fatty acid) laboratory rodent diet. | 1992 | Nutr Cancer | pmid:1584711 |
Woods MN | Role of n-3 fatty acids in prevention of disease complications in patients with HIV. | 2005 Jan-Mar | Nutr Clin Care | pmid:15850231 |
Montine TJ and Morrow JD | Fatty acid oxidation in the pathogenesis of Alzheimer's disease. | 2005 | Am. J. Pathol. | pmid:15855630 |
Kunesová M et al. | The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. | 2006 | Physiol Res | pmid:15857162 |
Carta G et al. | Recurrent miscarriage associated with antiphospholipid antibodies: prophylactic treatment with low-dose aspirin and fish oil derivates. | 2005 | Clin Exp Obstet Gynecol | pmid:15864938 |
Aïd S et al. | Dietary docosahexaenoic acid [22: 6(n-3)] as a phospholipid or a triglyceride enhances the potassium chloride-evoked release of acetylcholine in rat hippocampus. | 2005 | J. Nutr. | pmid:15867273 |
Lim SY et al. | Lead exposure and (n-3) fatty acid deficiency during rat neonatal development affect subsequent spatial task performance and olfactory discrimination. | 2005 | J. Nutr. | pmid:15867275 |
Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
Hirano H et al. | The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages. | 2005 | Oncol. Rep. | pmid:15870941 |
Djoussé L et al. | Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. | 2005 | J. Am. Coll. Cardiol. | pmid:15893192 |
Yin H et al. | Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. | 2005 | J. Biol. Chem. | pmid:15894799 |
Dhein S et al. | Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids. | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15900514 |
Menendez JA et al. | Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. | 2005 | Eur. J. Cancer Prev. | pmid:15901996 |
Van Maldergem L et al. | Orthotopic liver transplantation from a living-related donor in an infant with a peroxisome biogenesis defect of the infantile Refsum disease type. | 2005 | J. Inherit. Metab. Dis. | pmid:15902563 |
Filburn CR and Griffin D | Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. | 2005 | Vet. Ther. | pmid:15906268 |
Bazan NG | Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. | 2005 | Brain Pathol. | pmid:15912889 |
Duncan RE et al. | Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. | 2005 | Cancer Lett. | pmid:15914273 |
Chen S et al. | Importance of polyunsaturated acyl chains in chlorpromazine interaction with phosphatidylserines: a 13C and 31P solid-state NMR study. | 2005 | Biophys. Chem. | pmid:15921844 |
Hamazaki K et al. | Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial. | 2005 | Nutrition | pmid:15925295 |
Maki KC et al. | Lipid responses to a dietary docosahexaenoic acid supplement in men and women with below average levels of high density lipoprotein cholesterol. | 2005 | J Am Coll Nutr | pmid:15930485 |
Lin YH et al. | Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma. | 2005 | J. Lipid Res. | pmid:15930513 |
Li Q et al. | Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. | 2005 | J. Lipid Res. | pmid:15930520 |
Dabadie H et al. | Moderate intake of myristic acid in sn-2 position has beneficial lipidic effects and enhances DHA of cholesteryl esters in an interventional study. | 2005 | J. Nutr. Biochem. | pmid:15936650 |
Wilkinson P et al. | Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. | 2005 | Atherosclerosis | pmid:15939062 |
Speake BK and Wood NA | Timing of incorporation of docosahexaenoic acid into brain and muscle phospholipids during precocial and altricial modes of avian development. | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15939318 |
Seidel A et al. | The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. | 2005 | J Vet Med A Physiol Pathol Clin Med | pmid:15943605 |
Meng LP et al. | [Relationship between maternal DHA intake and DHA status and development of fetus and infant]. | 2005 | Wei Sheng Yan Jiu | pmid:15952672 |
Liu BH et al. | Effect of docosahexaenoic acid and arachidonic acid on the expression of adipocyte determination and differentiation-dependent factor 1 in differentiating porcine adipocytes. | 2005 | J. Anim. Sci. | pmid:15956459 |
Butovich IA et al. | Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid. | 2005 | Lipids | pmid:15957250 |
Senkal M et al. | Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue. | 2005 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:15961678 |
Hichami A et al. | Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. | 2005 | Am. J. Respir. Cell Mol. Biol. | pmid:15961724 |
Lu L et al. | Effects of different types of oxidative stress in RPE cells. | 2006 | J. Cell. Physiol. | pmid:15965958 |
Obajimi O et al. | Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. | 2005 | Pharmacol. Res. | pmid:15967385 |
Salem N et al. | Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. | 2005 | Exp. Eye Res. | pmid:15967432 |
Tritt KL et al. | Chemometric discrimination among wild and cultured age-0 largemouth bass, black crappies, and white crappies based on fatty acid composition. | 2005 | J. Agric. Food Chem. | pmid:15969511 |
Min Y et al. | Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. | 2005 | Diabet. Med. | pmid:15975108 |
Diau GY et al. | The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. | 2005 | BMC Med | pmid:15975147 |
Bowen RA and Clandinin MT | Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain. | 2005 | Br. J. Nutr. | pmid:15975158 |