Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Meng LP et al. | [Relationship between maternal DHA intake and DHA status and development of fetus and infant]. | 2005 | Wei Sheng Yan Jiu | pmid:15952672 |
Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
Xia Y et al. | [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. | 2007 | Wei Sheng Yan Jiu | pmid:17953212 |
Gong Q et al. | [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring]. | 2009 | Wei Sheng Yan Jiu | pmid:20047222 |
Huang H and Bao S | [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. | 2002 | Wei Sheng Wu Xue Bao | pmid:12557559 |
Wu K et al. | [Effects of phytohormones on growth and DHA production by Thraustochytrium roseum]. | 2003 | Wei Sheng Wu Xue Bao | pmid:16276880 |
Jiang X et al. | [Cloning and expression of two elongase genes involved in the biosynthesis of docosahexaenoic acid in Thraustochytrium sp. FJN-10]. | 2008 | Wei Sheng Wu Xue Bao | pmid:18437998 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Gladyshev MI et al. | [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. | 2006 | Vopr Pitan | pmid:16739608 |
Sergienko AA et al. | [Effects of docosahexaenoic and eicosapentaenoic acids on the state of metabolites of the prostacyclin I2--thromboxane A2 system in streptozotocin diabetes mellitus]. | 1992 Mar-Apr | Vopr Pitan | pmid:1387492 |
Ter-Karapetian VA | [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. | 1994 | Voen Med Zh | pmid:8165800 |
Semenova EM and Converse CA | Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. | 2003 | Vision Res. | pmid:14611942 |
Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
Filburn CR and Griffin D | Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. | 2005 | Vet. Ther. | pmid:15906268 |
Lecchi C et al. | In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. | 2011 | Vet. J. | pmid:20889357 |
Pisani LF et al. | In vitro modulatory effect of omega-3 polyunsaturated fatty acid (EPA and DHA) on phagocytosis and ROS production of goat neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19395090 |
Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
Nesbitt GH et al. | Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. | 2003 | Vet. Dermatol. | pmid:12662263 |
van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
Xue H et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. | 2006 | Vascul. Pharmacol. | pmid:16616699 |