DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. | 2013 | Adv Nutr | pmid:24228198 |
| Lotrich FE et al. | Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. | 2013 | J Psychosom Res | pmid:24182638 |
| Murphy EJ | A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. | 2013 | J. Neurochem. | pmid:24117623 |
| Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
| Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
| Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
| Lee LK et al. | The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. | 2013 | J. Nutr. Biochem. | pmid:22898566 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Gao M et al. | Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. | 2013 | J Oleo Sci | pmid:23470441 |
| Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
| Drover JR et al. | Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. | 2013 | Early Hum. Dev. | pmid:23411369 |
| Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
| Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Kimura AK and Kim HY | Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. | 2013 | J. Lipid Res. | pmid:23071296 |
| Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
| Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
| Morita M et al. | The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. | 2013 | Cell | pmid:23477864 |
| Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
| Miller E et al. | A short-term n-3 DPA supplementation study in humans. | 2013 | Eur J Nutr | pmid:22729967 |
| Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
| Friedman AN et al. | Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. | 2013 | Am. J. Nephrol. | pmid:23816975 |
| Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
| Gódor-Kacsándi A et al. | Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. | 2013 | Acta Physiol Hung | pmid:23524180 |
| Simões T et al. | Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. | 2013 | J. Food Sci. | pmid:23551246 |
| Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
| Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
| Al-Farsi YM et al. | Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. | 2013 | Nutrition | pmid:23800562 |
| Samieri C et al. | Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. | 2013 | J. Lipid Res. | pmid:23801662 |
| Wu JH et al. | Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. | 2013 | J Am Heart Assoc | pmid:24145742 |
| Végran F et al. | Socs3 induction by PPARγ restrains cancer-promoting inflammation. | 2013 | Cell Cycle | pmid:23803735 |
| Mizia-Stec K et al. | N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. | 2013 | Cardiol J | pmid:24469870 |
| Hunina LM et al. | [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. | 2013 | Fiziol Zh | pmid:23713352 |
| Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
| Qu L et al. | Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. | 2013 | Bioprocess Biosyst Eng | pmid:23673897 |
| Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
| Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
| Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
| Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
| Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
| Porta A et al. | Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. | 2013 | Chem. Phys. Lipids | pmid:23895793 |
| Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
| Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
| Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
| Ritter JC et al. | Quality analysis of commercial fish oil preparations. | 2013 | J. Sci. Food Agric. | pmid:23255124 |
| Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
| Siddiqui RA et al. | Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. | 2013 | BMC Cancer | pmid:24034496 |
| Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |
| Denis I et al. | Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. | 2013 | Ageing Res. Rev. | pmid:23395782 |