DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hoffman DR et al. | Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. | 1999 | Lipids | pmid:10443966 |
| Kelley DS et al. | Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. | 1999 | Lipids | pmid:10443964 |
| de Deckere EA | Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. | 1999 | Eur. J. Cancer Prev. | pmid:10443950 |
| Rodriguez de Turco EB et al. | Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis. | 1999 | J. Neurosci. Res. | pmid:10440897 |
| Singleton CB et al. | Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells. | 1999 | Br. J. Pharmacol. | pmid:10433502 |
| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. | 1999 | Neuroscience | pmid:10430487 |
| Pakala R et al. | Serotonin fails to induce proliferation of endothelial cells preloaded with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Atherosclerosis | pmid:10428304 |
| Guesnet P et al. | Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula. | 1999 | Am. J. Clin. Nutr. | pmid:10426708 |
| Terano T et al. | Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. | 1999 | Lipids | pmid:10419198 |
| Horrocks LA and Yeo YK | Docosahexaenoic acid-enriched foods: production and effects on blood lipids. | 1999 | Lipids | pmid:10419189 |
| Howe PR et al. | Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements. | 1999 | Lipids | pmid:10419186 |
| Harris WS | n-3 fatty acids and human lipoprotein metabolism: an update. | 1999 | Lipids | pmid:10419172 |
| Kim HY and Edsall L | The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. | 1999 | Lipids | pmid:10419168 |
| Glozman S et al. | Ethyl docosahexaenoic acid administration during intrauterine life enhances prostanoid production and reduces free radicals generation in the fetal rat brain. | 1999 | Lipids | pmid:10419167 |
| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Rotstein NP et al. | Essentiality of docosahexaenoic acid in retina photoreceptor cell development. | 1999 | Lipids | pmid:10419114 |
| Calviello G et al. | Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. | 1999 | Lipids | pmid:10419112 |
| Bougnoux P et al. | Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Lipids | pmid:10419111 |
| Finstad HS et al. | Proliferation and types of killing of leukemia cell lines by very long chain polyunsaturated fatty acids. | 1999 | Lipids | pmid:10419110 |
| Takahata K et al. | Protection from chemotherapy-induced alopecia by docosahexaenoic acid. | 1999 | Lipids | pmid:10419109 |
| McLennan PL and Raederstorff D | Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat. | 1999 | Lipids | pmid:10419102 |
| Birbes H et al. | Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. | 1999 | Lipids | pmid:10419092 |
| Crawford MA et al. | Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. | 1999 | Lipids | pmid:10419087 |
| Hamazaki T et al. | Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. | 1999 | Lipids | pmid:10419086 |
| Calviello G et al. | Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. | 1999 | Lipids | pmid:10405974 |
| Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
| Kafrawy O et al. | Docosahexaenoic acid in phosphatidylcholine mediates cytotoxicity more effectively than other omega-3 and omega-6 fatty acids. | 1998 | Cancer Lett. | pmid:10397449 |
| Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
| Wijendran V et al. | Maternal plasma phospholipid polyunsaturated fatty acids in pregnancy with and without gestational diabetes mellitus: relations with maternal factors. | 1999 | Am. J. Clin. Nutr. | pmid:10393139 |
| Harding CO et al. | Docosahexaenoic acid and retinal function in children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. | 1999 | J. Inherit. Metab. Dis. | pmid:10384386 |
| Yeh YY et al. | Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats. | 1999 | Lipids | pmid:10380120 |
| Smit EN et al. | Low erythrocyte docosahexaenoic acid in malnourished, often breast-fed, Pakistani infants: a matter of concern? | 1999 | Eur. J. Pediatr. | pmid:10378406 |
| Flock S et al. | Syntheses of some polyunsaturated sulfur- and oxygen-containing fatty acids related to eicosapentaenoic and docosahexaenoic acids. | 1999 | Acta Chem. Scand. | pmid:10377950 |
| Higgins S et al. | Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts. | 1999 | Mutagenesis | pmid:10375002 |
| Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
| Barichello JM et al. | Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids. | 1999 | Int J Pharm | pmid:10361163 |
| Kotkat HM et al. | Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10356759 |
| Marckmann P | Footprint of fish: docosahexaenoic acid (DHA) in adipose tissue. | 1999 | Nutrition | pmid:10355858 |
| Shahar E et al. | Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351918 |
| Roberts LJ et al. | Novel eicosanoids. Isoprostanes and related compounds. | 1999 | Methods Mol. Biol. | pmid:10343322 |
| Masuda R et al. | Incorporation of dietary docosahexaenoic acid into the central nervous system of the yellowtail Seriola quinqueradiata. | 1999 | Brain Behav. Evol. | pmid:10343083 |
| Hun CS et al. | Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334920 |