Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tanaka T et al. | Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail. A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata. | 2003 | Eur. J. Biochem. | pmid:12654002 |
Fischler L et al. | Influence of a parenteral fish-oil preparation (Omegaven) on erythrocyte morphology and blood viscosity in vitro. | 2003 | Clin. Hemorheol. Microcirc. | pmid:12652013 |
Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |
Smuts CM et al. | A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. | 2003 | Obstet Gynecol | pmid:12636950 |
Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
Engler MM et al. | Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. | 2003 | Exp. Biol. Med. (Maywood) | pmid:12626775 |
Chen WJ and Yeh SL | Effects of fish oil in parenteral nutrition. | 2003 | Nutrition | pmid:12620534 |
Suresh Y and Das UN | Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. | 2003 | Nutrition | pmid:12620523 |
[Sudden cardiac death. Targets every 2nd person without warning]. | 2003 | MMW Fortschr Med | pmid:12619216 | |
Narayanan BA et al. | Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. | 2003 | Cancer Res. | pmid:12615711 |
Mayer K et al. | Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12615625 |
Hibbeln JR et al. | Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. | 2003 | Biol. Psychiatry | pmid:12614996 |
Sturlan S et al. | Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. | 2003 | Blood | pmid:12609832 |
Akimoto M et al. | Lipase-catalyzed interesterification of soybean oil with an omega-3 polyunsaturated fatty acid concentrate prepared from sardine oil. | 2003 | Appl. Biochem. Biotechnol. | pmid:12603099 |
Terry PD et al. | Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. | 2003 | Am. J. Clin. Nutr. | pmid:12600840 |
McFadyen M et al. | Maternal and umbilical cord erythrocyte omega-3 and omega-6 fatty acids and haemorheology in singleton and twin pregnancies. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12598503 |
Aoki H et al. | Incorporation and accumulation of docosahexaenoic acid from the medium by Pichia methanolica HA-32. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596859 |
Araseki M et al. | Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596850 |
Usami M et al. | Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. | 2003 | Nutrition | pmid:12591548 |
Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
Hong S et al. | Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. | 2003 | J. Biol. Chem. | pmid:12590139 |
Berstad P et al. | Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. | 2003 | Clin. Sci. | pmid:12589702 |
Takeuchi T et al. | Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. | 2003 | Brain Res. | pmid:12573522 |
Ait-Said F et al. | Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. | 2003 | Biochim. Biophys. Acta | pmid:12573452 |
Saito M and Kubo K | Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. | 2003 | Br. J. Nutr. | pmid:12568661 |
Montine TJ et al. | Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. | 2003 | Biochem. Pharmacol. | pmid:12566089 |
Chiu CC et al. | Omega-3 fatty acids for depression in pregnancy. | 2003 | Am J Psychiatry | pmid:12562593 |
Kubo K et al. | Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation. | 2003 | Arch. Biochem. Biophys. | pmid:12559986 |
Howe PR et al. | Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. | 2002 | Lipids | pmid:12558057 |
Huang H and Bao S | [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. | 2002 | Wei Sheng Wu Xue Bao | pmid:12557559 |
De Vizia B et al. | Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. | 2003 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:12549599 |
Bakker EC et al. | Long-chain polyunsaturated fatty acids at birth and cognitive function at 7 y of age. | 2003 | Eur J Clin Nutr | pmid:12548302 |
Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
Lemaitre RN et al. | n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. | 2003 | Am. J. Clin. Nutr. | pmid:12540389 |
Kielar ML et al. | Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase. | 2003 | J. Am. Soc. Nephrol. | pmid:12538739 |
Sparreboom A et al. | Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. | 2003 | Clin. Cancer Res. | pmid:12538463 |
Qiu X | Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538082 |
Brenner RR | Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538079 |
Park Y and Harris W | EPA, but not DHA, decreases mean platelet volume in normal subjects. | 2002 | Lipids | pmid:12530552 |
De Swaaf ME et al. | High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. | 2003 | Biotechnol. Bioeng. | pmid:12529880 |
Wang Y et al. | Docosahexaenoic acid inhibits cytokine-induced expression of P-selectin and neutrophil adhesion to endothelial cells. | 2003 | Eur. J. Pharmacol. | pmid:12524156 |
Rousseau D et al. | Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12521943 |
Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
Kramer JA et al. | Transcription profiling in rat liver in response to dietary docosahexaenoic acid implicates stearoyl-coenzyme a desaturase as a nutritional target for lipid lowering. | 2003 | J. Nutr. | pmid:12514267 |
Woodman RJ et al. | Docosahexaenoic acid but not eicosapentaenoic acid increases LDL particle size in treated hypertensive type 2 diabetic patients. | 2003 | Diabetes Care | pmid:12502701 |
Francois CA et al. | Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. | 2003 | Am. J. Clin. Nutr. | pmid:12499346 |
Favrelière S et al. | DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. | 2003 Mar-Apr | Neurobiol. Aging | pmid:12498957 |
Cerbone AM et al. | [EPA and DHA ethyl esters: potential mechanisms of antischemic action]. | 1999 | Cardiologia | pmid:12497815 |
Briscoe CP et al. | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. | 2003 | J. Biol. Chem. | pmid:12496284 |
Yep YL et al. | Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. | 2002 | Asia Pac J Clin Nutr | pmid:12495260 |
Siddiqui RA et al. | Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. | 2003 | Biochem. J. | pmid:12492401 |
Catalan J et al. | Cognitive deficits in docosahexaenoic acid-deficient rats. | 2002 | Behav. Neurosci. | pmid:12492301 |
Hashimoto M et al. | [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491779 |
Baker SD et al. | Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. | 2002 | J. Natl. Cancer Inst. | pmid:12488482 |
Amiano P et al. | Very-long-chain omega-3 fatty acids as markers for habitual fish intake in Spain. | 2002 | IARC Sci. Publ. | pmid:12484164 |
Woodman RJ et al. | Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. | 2003 | Atherosclerosis | pmid:12482554 |
Igarashi T et al. | Determination of docosahexaenoic acid and n-3 fatty acids in refined fish oils by 1H-NMR spectroscopy: IUPAC interlaboratory study. | 2002 Nov-Dec | J AOAC Int | pmid:12477198 |
Seebungkert B and Lynch JW | Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. | 2002 | Eur. J. Neurosci. | pmid:12473076 |
Diep QN et al. | PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. | 2002 | Hypertension | pmid:12468571 |
Furuya H et al. | Effect of ethanol and docosahexaenoic acid on nerve growth factor-induced neurite formation and neuron specific growth-associated protein gene expression in PC12 cells. | 2002 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:12462067 |
Bourre JM and Dumont O | The administration of pig brain phospholipids versus soybean phospholipids in the diet during the period of brain development in the rat results in greater increments of brain docosahexaenoic acid. | 2002 | Neurosci. Lett. | pmid:12459515 |
Guallar E et al. | Mercury, fish oils, and the risk of myocardial infarction. | 2002 | N. Engl. J. Med. | pmid:12456850 |
Wang YW et al. | Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. | 2002 | Poult. Sci. | pmid:12455601 |
Pratt VC et al. | Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. | 2002 | Br. J. Cancer | pmid:12454764 |
Passi S et al. | Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish. | 2002 | J. Agric. Food Chem. | pmid:12452651 |
Andersson A et al. | Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12450886 |
Kearns SD and Haag M | The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445489 |
Wang L and Muttucumaru S | Separation of biosynthetic polyunsaturated fatty acid (PUFA) with supercritical fluid. | 2002 | Biotechnol Annu Rev | pmid:12436919 |
Meireles LA et al. | Increase of the yields of eicosapentaenoic and docosahexaenoic acids by the microalga Pavlova lutheri following random mutagenesis. | 2003 | Biotechnol. Bioeng. | pmid:12432580 |
Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
Montine TJ et al. | Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. | 2002 | J. Neurochem. | pmid:12423256 |
Abhyankar B | Further reduction in mortality following myocardial infarction. | 2002 | Hosp Med | pmid:12422496 |
Bowen RA and Clandinin MT | Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. | 2002 | J. Neurochem. | pmid:12421348 |
Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
van Wezel-Meijler G et al. | Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. | 2002 | Acta Paediatr. | pmid:12412870 |
Nordøy A | Statins and omega-3 fatty acids in the treatment of dyslipidemia and coronary heart disease. | 2002 | Minerva Med. | pmid:12410168 |
Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
Glew RH et al. | The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401435 |
Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
Woodman RJ et al. | Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. | 2002 | Am. J. Clin. Nutr. | pmid:12399272 |
Rodriguez de Turco EB et al. | Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. | 2002 | J. Neurochem. | pmid:12390513 |
Ye D et al. | Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388664 |
Quan LG and Cha JK | Preparation of isoprostanes and neuroprostanes. | 2002 | J. Am. Chem. Soc. | pmid:12381179 |
Saito M and Kubo K | An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats. | 2002 | Ann. Nutr. Metab. | pmid:12378040 |
Wu T et al. | Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. | 2002 | Lipids | pmid:12371750 |
Brzustowicz MR et al. | Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. | 2002 | Biochemistry | pmid:12369842 |
Acar N et al. | Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. | 2002 | J. Nutr. | pmid:12368410 |
Mathews SA et al. | Comparison of triglycerides and phospholipids as supplemental sources of dietary long-chain polyunsaturated fatty acids in piglets. | 2002 | J. Nutr. | pmid:12368399 |
Hulbert AJ et al. | Acyl composition of muscle membranes varies with body size in birds. | 2002 | J. Exp. Biol. | pmid:12364409 |
Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
AbuGhazaleh AA et al. | Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. | 2002 | J. Dairy Sci. | pmid:12362459 |
Sergeeva M et al. | Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation. | 2002 | J. Neurochem. | pmid:12358772 |
Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | 2002 | Mol. Vis. | pmid:12355064 |
Krasevec JM et al. | Maternal and infant essential fatty acid status in Havana, Cuba. | 2002 | Am. J. Clin. Nutr. | pmid:12324298 |
Martin RE et al. | Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324228 |
Williard DE et al. | Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324227 |
Ghys A et al. | Red blood cell and plasma phospholipid arachidonic and docosahexaenoic acid levels at birth and cognitive development at 4 years of age. | 2002 | Early Hum. Dev. | pmid:12324186 |
Burdge GC et al. | Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain. | 2002 | Br. J. Nutr. | pmid:12323087 |
Chapkin RS et al. | Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures. | 2002 | Clin. Exp. Immunol. | pmid:12296847 |