DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kajita M et al. | Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. | 2000 | J Pharm Sci | pmid:10980499 |
| Fidler N et al. | Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. | 2000 | J. Lipid Res. | pmid:10974044 |
| Dagnelie G et al. | Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. | 2000 | Optometry | pmid:10970259 |
| Wander RC and Du SH | Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids. | 2000 | Am. J. Clin. Nutr. | pmid:10966891 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. | 2000 | Am. J. Clin. Nutr. | pmid:10966889 |
| Marangoni F et al. | Polyunsaturated fatty acid concentrations in human hindmilk are stable throughout 12-months of lactation and provide a sustained intake to the infant during exclusive breastfeeding: an Italian study. | 2000 | Br. J. Nutr. | pmid:10961166 |
| Liu QY and Tan BK | Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. | 2000 | Life Sci. | pmid:10954054 |
| Kohno H et al. | Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats. | 2000 Sep-Oct | Oncol. Rep. | pmid:10948340 |
| Surai PF and Sparks NH | Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. | 2000 | Poult. Sci. | pmid:10947182 |
| Retterstøl K et al. | Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol. | 2000 | Alcohol | pmid:10946154 |
| Guo X and Ota Y | Incorporation of eicosapentaenoic and docosahexaenoic acids by a yeast (FO726A). | 2000 | J. Appl. Microbiol. | pmid:10945786 |
| Albino AP et al. | Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. | 2000 | Cancer Res. | pmid:10945621 |
| Fritsche KL et al. | Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma production in vivo. | 2000 | J. Infect. Dis. | pmid:10944484 |
| Vanderhoof J et al. | A multicenter long-term safety and efficacy trial of preterm formula supplemented with long-chain polyunsaturated fatty acids. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941962 |
| Healy DA et al. | Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. | 2000 | Lipids | pmid:10941877 |
| Arterburn LM et al. | A developmental safety study in rats using DHA- and ARA-rich single-cell oils. | 2000 | Food Chem. Toxicol. | pmid:10930697 |
| Kimura S | [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. | 2000 | Yakugaku Zasshi | pmid:10920715 |
| Everts S and Davis JH | 1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. | 2000 | Biophys. J. | pmid:10920020 |
| Mukhopadhyay S et al. | Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of guinea pig alveolar apical membranes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913226 |
| Smit EN et al. | Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913225 |
| Matthews KR et al. | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. | 2000 | Br. J. Nutr. | pmid:10911772 |
| Ando Y et al. | Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. | 2000 | Lipids | pmid:10907794 |
| Ghebremeskel K et al. | Blood fatty acid composition of pregnant and nonpregnant Korean women: red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. | 2000 | Lipids | pmid:10907792 |
| Martin RE et al. | Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells. | 2000 | Neurochem. Res. | pmid:10905634 |
| de Turco EB et al. | Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl]phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. | 2000 | Neurochem. Res. | pmid:10905632 |
| Kim HY et al. | Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. | 2000 | J. Biol. Chem. | pmid:10903316 |
| Xiao YF et al. | Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10899039 |
| Kontogiannea M et al. | omega-3 fatty acids decrease endothelial adhesion of human colorectal carcinoma cells. | 2000 | J. Surg. Res. | pmid:10896822 |
| Young C et al. | Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. | 2000 | Synapse | pmid:10881029 |
| Lesage F et al. | Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. | 2000 | J. Biol. Chem. | pmid:10880510 |
| de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
| Morishita M et al. | The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA. | 2000 | Int J Pharm | pmid:10878324 |
| Kumar KV et al. | Oxidant stress and essential fatty acids in patients with risk and established ARDS. | 2000 | Clin. Chim. Acta | pmid:10876008 |
| Gao YC and Charter EA | Nutritionally important fatty acids in hen egg yolks from different sources. | 2000 | Poult. Sci. | pmid:10875777 |
| Narita K et al. | Therapeutic time window in the penumbra during permanent focal ischemia in rats: changes of free fatty acids and glycerophospholipids. | 2000 | Neurol. Res. | pmid:10874689 |
| Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
| Decsi T and Koletzko B | Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. | 2000 | Nutrition | pmid:10869902 |
| Kubo K et al. | Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. | 2000 | J. Nutr. | pmid:10867046 |
| Torres IC et al. | Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits. | 2000 | Br. J. Nutr. | pmid:10858695 |
| Kosugi Y et al. | Esterification of polyunsaturated fatty acids by various forms of immobilized lipase from Rhizomucor miehei. | 2000 | Lipids | pmid:10858032 |
| Morris S et al. | Utilization of docosahexaenoic acid from intravenous egg yolk phospholipid. | 2000 | Lipids | pmid:10858022 |
| Giusto NM et al. | Lipid metabolism in vertebrate retinal rod outer segments. | 2000 | Prog. Lipid Res. | pmid:10856601 |
| Kielar ML et al. | Docosahexaenoic acid decreases IRF-1 mRNA and thus inhibits activation of both the IRF-E and NFkappa d response elements of the iNOS promoter. | 2000 | Transplantation | pmid:10852612 |
| Marx N et al. | Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. | 2000 | J. Immunol. | pmid:10843708 |
| Watanabe S et al. | Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841036 |
| Jahangiri A et al. | Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids. | 2000 | Mol. Cell. Biochem. | pmid:10839192 |
| Smit EN et al. | Breast milk docosahexaenoic acid (DHA) correlates with DHA status of malnourished infants. | 2000 | Arch. Dis. Child. | pmid:10833187 |
| Huster D et al. | Strength of Ca(2+) binding to retinal lipid membranes: consequences for lipid organization. | 2000 | Biophys. J. | pmid:10827979 |
| Lim SY and Suzuki H | Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. | 2000 | J. Nutr. | pmid:10827221 |
| Farkas T et al. | Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823917 |