DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yi SH et al. | A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22000478 |
| Sidhu VK et al. | Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling. | 2011 | J. Proteome Res. | pmid:22003853 |
| Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
| Granot E et al. | DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. | 2011 | Mediators Inflamm. | pmid:21941411 |
| Rahman M et al. | Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. | 2011 | PLoS ONE | pmid:22140508 |
| Johnson B | Consciousness reinstated using the certainty principle--a better mental health strategy. | 2011 | Nutr Health | pmid:22141192 |
| Westphal C et al. | CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21945326 |
| Wood PL et al. | Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease. | 2011 | Lipids Health Dis | pmid:22142382 |
| Decsi T et al. | Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in pregnant women and their newborns: data from three European countries. | 2011 | Ann. Nutr. Metab. | pmid:22142767 |
| Kohlboeck G et al. | Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. | 2011 | Am. J. Clin. Nutr. | pmid:22071708 |
| Park CK et al. | Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. | 2011 | J. Neurosci. | pmid:22016541 |
| James S et al. | Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). | 2011 | Cochrane Database Syst Rev | pmid:22071839 |
| Ulven SM et al. | Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. | 2011 | Lipids | pmid:21042875 |
| Morin C et al. | Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21057106 |
| Gajos G | The fish oil story--back to Greenland? | 2011 | Cardiology | pmid:21757896 |
| Ozsoy O et al. | The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. | 2011 | Neurochem. Int. | pmid:21736911 |
| Haraguchi T et al. | Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21737922 |
| Johnsen GM et al. | Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. | 2011 | Placenta | pmid:21741084 |
| Lespérance F et al. | The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. | 2011 | J Clin Psychiatry | pmid:20584525 |
| Keithly JI et al. | Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexaenoic acid. | 2011 | J. Anim. Sci. | pmid:21742943 |
| Sun H et al. | Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. | 2011 | Carcinogenesis | pmid:21771724 |
| Caputo M et al. | Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. | 2011 | J. Cell. Physiol. | pmid:20648548 |
| Opreanu M et al. | The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. | 2011 | Diabetes | pmid:21771974 |
| Serebruany VL et al. | Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. | 2011 | Cardiology | pmid:21701167 |
| Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
| Walczewska A et al. | [The role of docosahexaenoic acid in neuronal function]. | 2011 | Postepy Hig Med Dosw (Online) | pmid:21677356 |
| Davis-Bruno K and Tassinari MS | Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. | 2011 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:21678548 |
| Klingler M et al. | Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. | 2011 | Lipids | pmid:21681560 |
| Friedrichs W et al. | Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. | 2011 | Nutr Cancer | pmid:21667400 |
| Sakayori N et al. | Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. | 2011 | Genes Cells | pmid:21668588 |
| Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
| Cook DJ and Heyland DK | Pharmaconutrition in acute lung injury. | 2011 | JAMA | pmid:21976612 |
| Rice TW et al. | Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. | 2011 | JAMA | pmid:21976613 |
| Faragó N et al. | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. | 2011 | Lipids Health Dis | pmid:21961478 |
| Wu A et al. | The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. | 2011 | J. Neurotrauma | pmid:21851229 |
| Weise C et al. | Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells. | 2011 | J. Nutr. Biochem. | pmid:20576420 |
| Lalancette-Hébert M et al. | Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. | 2011 | Stroke | pmid:21852616 |
| Schuchardt JP et al. | Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. | 2011 | Lipids Health Dis | pmid:21854650 |
| Murakami M | Lipid mediators in life science. | 2011 | Exp. Anim. | pmid:21325748 |
| Beck G et al. | Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. | 2011 | J. Neurosci. | pmid:21813701 |
| Konrad M et al. | The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. | 2011 | Int J Sport Nutr Exerc Metab | pmid:21813917 |
| Morin C et al. | 19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca²⺠sensitivity in human pulmonary arteries. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21821782 |
| Kuipers RS et al. | Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. | 2011 | Med. Hypotheses | pmid:21388747 |
| Boucher O et al. | Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. | 2011 | Am. J. Clin. Nutr. | pmid:21389181 |
| Grant GE et al. | Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. | 2011 | Carcinogenesis | pmid:21393477 |
| Trofimiuk E and Braszko JJ | Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. | 2011 | Lipids | pmid:21442272 |
| Chauveau F et al. | Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. | 2011 | Curr Neurovasc Res | pmid:21443458 |
| Collins CT et al. | Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. | 2011 | Br. J. Nutr. | pmid:21443815 |
| Sala-Vila A et al. | Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. | 2011 | Br. J. Nutr. | pmid:21450116 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Sublette ME et al. | Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. | 2011 | J Clin Psychiatry | pmid:21939614 |
| Serini S et al. | Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved. | 2011 | Curr. Med. Chem. | pmid:21824086 |
| Fagali N and Catalá A | Melatonin and structural analogues do not possess antioxidant properties on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. | 2011 | Chem. Phys. Lipids | pmid:21827740 |
| Newens KJ et al. | DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity. | 2011 | Am. J. Clin. Nutr. | pmid:21831993 |
| von Schacky C | The Omega-3 Index as a risk factor for cardiovascular diseases. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21726658 |
| Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
| Dewell A et al. | Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. | 2011 | J. Nutr. | pmid:22031659 |
| Berry KA et al. | MALDI imaging MS of phospholipids in the mouse lung. | 2011 | J. Lipid Res. | pmid:21508254 |
| Klebanoff MA et al. | Fish consumption, erythrocyte fatty acids, and preterm birth. | 2011 | Obstet Gynecol | pmid:21508745 |
| Altenburg JD et al. | A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. | 2011 | BMC Cancer | pmid:21510869 |
| Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
| Hadders-Algra M | Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. | 2011 | Am. J. Clin. Nutr. | pmid:21525202 |
| Escolano-Margarit MV et al. | Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. | 2011 | J. Nutr. | pmid:21525247 |
| Rockett BD et al. | Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. | 2011 | J. Nutr. | pmid:21525263 |
| De Franceschi G et al. | Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. | 2011 | J. Biol. Chem. | pmid:21527634 |
| Hanada H et al. | Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs. | 2011 | Cell Biol. Int. | pmid:20812919 |
| Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
| Nudda A et al. | Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. | 2011 | J. Food Sci. | pmid:21535766 |
| Yu YH et al. | The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes. | 2011 | J. Nutr. Biochem. | pmid:20970313 |
| Pomponi MF et al. | Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? | 2011 | Ageing Res. Rev. | pmid:20920611 |
| Wojcicki JM and Heyman MB | Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:20925595 |
| Kim SH et al. | Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. | 2011 | Eur J Clin Nutr | pmid:20877395 |
| Neubronner J et al. | Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters. | 2011 | Eur J Clin Nutr | pmid:21063431 |
| Sasaki K et al. | Total synthesis and bioactivities of two proposed structures of maresin. | 2011 | Chem Asian J | pmid:21254430 |
| Huang L et al. | Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. | 2011 | Pain | pmid:21255928 |
| van der Pols JC et al. | Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. | 2011 | Cancer Epidemiol. Biomarkers Prev. | pmid:21217086 |
| Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
| Poudel-Tandukar K et al. | Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. | 2011 | J Affect Disord | pmid:20692041 |
| Mariee AD and Abd-Ellah MF | Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. | 2011 | Ren Fail | pmid:21219208 |
| Safarinejad MR | Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. | 2011 | Andrologia | pmid:21219381 |
| Cotogni P et al. | Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. | 2011 | JPEN J Parenter Enteral Nutr | pmid:21224438 |
| Burrows T et al. | Omega-3 index, obesity and insulin resistance in children. | 2011 | Int J Pediatr Obes | pmid:21226540 |
| Zhao Y et al. | Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. | 2011 | PLoS ONE | pmid:21246057 |
| Ueda Y et al. | Effect of dietary lipids on longevity and memory in the SAMP8 mice. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:21512289 |
| Cavazos DA et al. | Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. | 2011 | Prostate | pmid:21360560 |
| Murphy RA et al. | Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. | 2011 | Cancer | pmid:21360698 |
| Swenne I et al. | Essential fatty acid status in teenage girls with eating disorders and weight loss. | 2011 | Acta Paediatr. | pmid:21362034 |
| Van Dyke TE | Proresolving lipid mediators: potential for prevention and treatment of periodontitis. | 2011 | J. Clin. Periodontol. | pmid:21323709 |
| Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
| Harper KN et al. | Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. | 2011 | Schizophr. Res. | pmid:21324652 |
| Grimm MO et al. | Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms. | 2011 | J. Biol. Chem. | pmid:21324907 |
| Marc I et al. | Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants. | 2011 | J. Nutr. | pmid:21169226 |
| Shimshoni JA et al. | Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. | 2011 | Biochim. Biophys. Acta | pmid:21184843 |
| Serini S et al. | Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. | 2011 | J. Nutr. Biochem. | pmid:21185708 |
| Wang RX et al. | Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. | 2011 | Cardiovasc. Res. | pmid:21187320 |
| Riedel M et al. | Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. | 2011 | J. Mol. Neurosci. | pmid:20725866 |
| Hamazaki K et al. | Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21196723 |
| Cho JY et al. | Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. | 2011 | Mol Nutr Food Res | pmid:20824662 |
| Pawlik D et al. | Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. | 2011 | Pediatrics | pmid:21199856 |